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Centromere licensing: Mis18 is required to Polo-ver.

Meghan C Barnhart-Dailey, Daniel R Foltz
Current Biology : CB 2014 September 9
The Mis18 complex is a critical player in determining when and where centromeres are built. A new study identifies Polo-like kinase (Plk1) as a positive regulator required for the localization of Mis18 to centromeres. This is a critical step that is essential for proper centromere function and maintaining the integrity of the genome.

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