Renal Pathology: SY23-2 A CASE OF A NEW DISEASE ENTITY: PODOCYTIC INFOLDING GLOMERULOPATHY.

A 41-year-old woman was discovered to have enteric infection of Aeromonas caviae and was treated with antibiotics. Subsequently she developed nephrotic syndrome. Renal biopsy showed a non-argentaffine hole in the glomerular basement membrane (GBM) in PAM stain with IgG and C3 deposition. This finding was similar to membranous glomerulonephritis. However, electron microscopy showed no electron dense deposits but microspheres or microtubular structures associated with podocytic infolding into the GBM. Corticosteroid treatment resulted in rapid remission. This case corresponds to a new disease entity of podocytic infolding glomerulopathy, which was proposed by a working group of The Japanese Society of Nephrology on the basis of 25 cases corrected from 17 institutions all over Japan. The question arises whether these morphological changes are specific for a new disease entity or they could reflect a nonspecific cellular response of the podocyte to an injury.