[Ovarian stimulation with gonadotropins: comparison between recombinant FSH plus menotropins versus recombinant FSH + LH].

BACKGROUND: Nowadays various assisted reproduction ovarian stimulation schemes are used for different clinical outcomes is interesting to compare.

OBJECTIVE: Compare two ovarian stimulation protocols: recombinant FSH + LH versus recombinant FSH + Menotropins.

MATERIAL AND METHODS: Observational, retrospective study, 38 cycles were analyzed, made from 2010 until 2013, assigned to two groups (n = 19 each), group 1 received FSHr + LHr, group 2 received FSHr + menotropins. Study variables were: days of ovarian stimulation, total gonadotropin dose, retrieved oocytes, fertilization rate, pregnancy rate and number of vitrified embryos.

RESULTS: Fewer stimulation days (8.5 +/- 1.5 vs 9 +/- 1.1) were found in group 1 (recombinant gonadotropins). Group 2 (FSHr + Menotropins), had a greater total dose of gonadotropins (1930.2 +/- 346.2 vs 2000 +/- 418.8) and more retrieved oocytes (8.15 +/- 3.9 vs 8.57 +/- 4). Group 1 patients had higher pregnancy and fertilization rates (56.2 vs 36.8%, and 75.4 vs 69.3%) respectively, no statistical significance was found.

CONCLUSION: This study found higher pregnancy and fertilization rates in patients treated with recombinant gonadotropins (FSH + LH) for ovarian stimulation.