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Comparison of labial minor salivary gland biopsies from childhood Sjögren syndrome and age-matched controls.

OBJECTIVE: To determine an appropriate focus score cutoff for childhood Sjögren syndrome (SS).

METHODS: Labial salivary gland tissue from specimens from children with SS and age-matched controls was retrospectively identified and reviewed by a blinded oral pathologist.

RESULTS: The presence of any focal sialadenitis (focus score > 0 foci/4 mm(2)) was common among childhood SS samples but present in only 1 of 8 control samples.

CONCLUSION: The presence of any focal lymphocytic sialadenitis in minor labial salivary gland tissue is suggestive of childhood SS and should be included in future childhood SS-specific diagnostic or classification criteria.

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