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Phenolic constituents from the roots of Phyllodium pulchellum

Yang Zong, Ming Zhong, Dong-Mei Li, Bao-Jing Zhang, Zhen-Peng Mai, Xiao-Kui Huo, Shan-Shan Huang, Hou-Li Zhang, Chao Wang, Xiao-Chi Ma, Sheng-Min Yu, Dong-Ai Yang
Journal of Asian Natural Products Research 2014, 16 (7): 741-6
Three new phenolic constituents 1-3 were obtained from the 95% ethanol extract of the roots of Phyllodium pulchellum (Leguminosae). Their structures were elucidated on the basis of spectroscopic analyses, such as NMR, UV, IR, HR-ESI-MS, and CD. Furthermore, in an in vitro bioassay, all compounds were tested for inhibitory effects against the proliferation of acetaldehyde-stimulated HSC-T6 cells, and compound 3 exhibited potent inhibitory activity with the IC50 value of 7.6 μM.


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