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JOURNAL ARTICLE
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[Effect of subanaesthetic dose of ketamine on mechanical stimulus on brain regions].

OBJECTIVE: To investigate the effect of subanaesthetic dose of ketamine on mechanical stimulus on brain regions.

METHODS: Totally 13 healthy male volunteers were enrolled in this study,in whom 0 and 100 ng/ml ketamine were administrated by target controlled infusion system in pilot study.After von Frey filaments(vFFs)300 g were used as mechanical stimuli,Visual Analogue Scale scores were evaluated.Functional magnetic resonance imaging(fMRI)was taken 1 week after pilot study at the following sequences:structure imaging+functional imaging(stimulus sequence with 300 g vFFs,ketamine sequence);stimulus sequence=6×(20s on+20s off),with target concentration of ketamine at 0,100 ng/ml.fMRI result was processed by SPM2 and Metlab 7.01 software package.

RESULTS: Posterior cerebellum lobe and corpus callosum were inhibited at 100 ng/ml under vFFs stimulus,whereas cingulate gyrus,middle frontal gyrus,inferior parietal lobule,occipital lobe,and posterior cerebellum lobe were activated at 100 ng/ml under vFFs stimulus.

CONCLUSIONS: Ketamine 100 ng/ml exerts its effect on pain related brain regions.It can both activate and inhibit these brain regions,with the activating effect being the primary effect.

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