[The humoral immunity changes in experimental cranio-cerebral trauma, concurrent with diabetes mellitus].

The results of studying in dynamics of the humoral immunity indices were adduced in experimental cranio-cerebral truma (CCT) in conjunction with diabetes mellitus (DM). Peculiarities of the immune answer while the period of an acute reaction on trauma and early signs of posttraumatic period have been characterized by reduction of content in the main classes of immunoglobulins IgA, IgM, IgG and enhancement of the circulating immune complexes (CIC) concentration. Experimental DM was accompanied by raising of functional activity of humoral immunity in accordance with immunoglobulins level and CIC. The specificity of changes in humoral immunity in conditions of CCT on the DM background consisted of more profound lowering of the immunoglobulins level and rapid enhancement of the CIC content.