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UV-visible spectrophotometric simultaneous estimation of paracetamol and nabumetone by AUC method in combined tablet dosage form.
Pharmaceutical Methods 2012 January
INTRODUCTION: The present study deals with development and validation of a simple, rapid, sensitive and economic area under curve method for simultaneous estimation of paracetamol and nabumetone in bulk and tablet dosage form.
MATERIALS AND METHOD: Area under curve method includes determination of area of paracetamol and nabumetone at absorption maxima, which for paracetamol was 248.8 ± 10 nm and for nabumetone was 269.2 ± 10 nm. Beer's law was obeyed in the concentration range of 5-25 μg/mL for both paracetamol and nabumetone. Correlation coefficient was found to be 0.9983 and 0.9993 for paracetamol and nabumetone, respectively for area under curve method.
RESULTS: The analysis were validated statistically and by performing recovery studies. The mean percent recoveries were found satisfactory for the proposed method. The percentage recovery was found to be 101.67-102.43% for paracetamol and 96.69-98.49% for nabumetone.
CONCLUSION: The proposed AUC method used for the simultaneous estimation of PARA and NAB in bulk and tablet dosage formrespectively.
MATERIALS AND METHOD: Area under curve method includes determination of area of paracetamol and nabumetone at absorption maxima, which for paracetamol was 248.8 ± 10 nm and for nabumetone was 269.2 ± 10 nm. Beer's law was obeyed in the concentration range of 5-25 μg/mL for both paracetamol and nabumetone. Correlation coefficient was found to be 0.9983 and 0.9993 for paracetamol and nabumetone, respectively for area under curve method.
RESULTS: The analysis were validated statistically and by performing recovery studies. The mean percent recoveries were found satisfactory for the proposed method. The percentage recovery was found to be 101.67-102.43% for paracetamol and 96.69-98.49% for nabumetone.
CONCLUSION: The proposed AUC method used for the simultaneous estimation of PARA and NAB in bulk and tablet dosage formrespectively.
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