Influence of zinc hydroaspartate on the anti-inflammatory and gastric activity of ketoprofen in rats.

Magdalena Gaweł, Tadeusz Librowski, Anna Lipkowska

Pharmacological Reports : PR 2013

BACKGROUND: The study's aim was to evaluate the anti-inflammatory effect and influence on gastric mucosa after the combined administration of ketoprofen and zinc hydroaspartate (ZHA, 60 mg/kg).

METHODS: Antiedematous activity was determined according toWinter et al., analgesic activity according to the Randall and Selitto test, the influence on gastric mucosa in accordance to Komatsu.

RESULTS: Single and subchronic administration of ZHA and single ketoprofen po caused a significant reduction of the rat hind paw edema in comparison to the control groups. ZHA alone administrated ip four times was active after the 1st, 2nd and 3rd h from the carrageenan injection.

CONCLUSIONS: ZHA enhanced the anti-inflammatory effect of ketoprofen.

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