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JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Collagen stimulating effect of peptide amphiphile C16-KTTKS on human fibroblasts.
Molecular Pharmaceutics 2013 March 5
The collagen production of human dermal and corneal fibroblasts in contact with solutions of the peptide amphiphile (PA) C16-KTTKS is investigated and related to its self-assembly into nanotape structures. This PA is used in antiwrinkle cosmeceutical applications (trade name Matrixyl). We prove that C16-KTTKS stimulates collagen production in a concentration-dependent manner close to the critical aggregation concentration determined from pyrene fluorescence spectroscopy. This suggests that self-assembly and the stimulation of collagen production are inter-related.
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