Ophthalmology manifestations of pediatric cancer treatment.

PURPOSE OF REVIEW: Advances in pediatric oncology care have increased survival rates for children with malignancy. As a result, ophthalmologists are seeing more short-term and long-term complications associated with the treatment of these conditions. Ophthalmologists need to be aware of cancer treatment-related eye disorders.

RECENT FINDINGS: Multiple eye findings are associated with cancer treatment, including chemotherapy, radiation, bone marrow transplantation, and newer modalities such as intra-arterial chemotherapy. Malignancy and treatment cause immunodeficiency that can lead to infectious disease manifestations, including eye involvement. Our understanding of the prevalence of eye involvement in infectious diseases is changing due to newer antimicrobial treatment modalities and earlier screening. Paraneoplastic conditions may manifest with eye findings either before the diagnosis of the primary malignancy or as a late finding. The evolution of IVF has raised concerns of increased cancer risks, including ocular tumors.

SUMMARY: Ophthalmologists who are involved with the care of children undergoing cancer treatment need to be aware of the many eye manifestations that may result.