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JOURNAL ARTICLE

Efficient synthesis of γ-keto sulfones by NHC-catalyzed intermolecular Stetter reaction

Anup Bhunia, Santhivardhana Reddy Yetra, Sachin Suresh Bhojgude, Akkattu T Biju
Organic Letters 2012 June 1, 14 (11): 2830-3
22583126
The N-heterocyclic carbene-catalyzed intermolecular Stetter reaction of aldehydes with α,β-unsaturated sulfones allows the atom-economic and selective formation of γ-keto sulfones in good yields. Key to the success of this unique transition-metal-free carbon-carbon bond-forming reaction is the right choice of the NHC precursor and base. The reaction tolerates a broad range of different aldehydes.

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