We have located links that may give you full text access.
Effect of corticosterone and dexamethasone on glucocorticoid receptor in lactating rat mammary gland.
Endocrinologia Experimentalis 1990 September
The effects of either a single dose or long-term administration of corticosterone or dexamethasone 21-acetate (Dex Ac) on glucocorticoid receptor concentration in mammary gland cytosol of lactating adrenalectomized rats were investigated. Adrenalectomy on lactation day 7 failed to affect the glucocorticoid receptors significantly. Both the natural and synthetic steroid caused a rapid decrease of receptor binding in the cytosol but the time course of glucocorticoid receptor depletion was different. Complete depletion of cytosol receptor was observed after both a single s.c. Dex Ac dose (20 micrograms/100 g) and after long-term oral treatment (10 micrograms/ml saline as drinking solution for 6 days) immediately after the last steroid dose. In the first case the depletion was still observable at 24 h after the injection without any change in Kd. In contrast, prolonged administration of Dex Ac maintained the receptor binding low even for 48 h after steroid withdrawal and resulted in an increased Kd. Even after an additional day the binding did not exceed the level of 50% of controls. By that time, however, Kd has returned to normal values. On the other hand, a single dose of corticosterone (100 micrograms/100 g) as well as long-term corticosterone treatment (100 micrograms/ml saline as drinking solution for 6 days) reduced the glucocorticoid receptor concentration only to 60% and 25%, respectively. Twenty four hours after the hormone administration the receptor binding returned to control level, no change in Kd being observed. It was concluded that Dex Ac, but not corticosterone, down-regulates the glucocorticoid receptors in mammary gland cytosol of lactating rats.
Full text links
Trending Papers
A Personalized Approach to the Management of Congestion in Acute Heart Failure.Heart International 2023
Potential Mechanisms of the Protective Effects of the Cardiometabolic Drugs Type-2 Sodium-Glucose Transporter Inhibitors and Glucagon-like Peptide-1 Receptor Agonists in Heart Failure.International Journal of Molecular Sciences 2024 Februrary 21
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app