[Pharmacological approaches in immuno-rhumatology].

Biologics have proven to be an effective treatment option for adults with rheumatoid arthritis but their use in clinical practice may be limited by concerns over severe side effects and cost. Pharmacology and development of biomarkers could help to optimize the use of biologics in clinical practice. Biomarkers are surrogate markers and include all diagnostic tests, imaging and technologies and any other objective measure of a person's health status and all pharmacodiagnostic tests. Several studies evaluated interest of biomarkers in RA patients treated with biologics: 1- to optimize doses and frequency of drug administration; 2- to predict response to treatment; 3- to predict tolerance of biologics; 4- to monitor patient who stopped treatment and are in remission, and predict new RA flare.