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Journal Article
Research Support, Non-U.S. Gov't
Coagulation and prothrombotic state parameters: a clinical analysis during early pregnancy.
Irish Journal of Medical Science 2011 December
AIM: The aim of this study is to assess the changes in coagulation, thrombosis, anticoagulation, and fibrinolysis during early pregnancy.
METHODS: One hundred and five pregnant women with monozygotic pregnancies between 10 and 12 weeks gestation were randomly enrolled as the study group, and another 82 non-pregnant women were selected as the control group. Coagulation parameters and prothrombotic state parameters were measured.
RESULTS: Fg, F1 + 2, thrombin-antithrombin complex, GMP140, D-dimer, and plasminogen activator inhibitor 2 were statistically different between the study and the control groups (p < 0.008). The coagulation, fibrinolytic, and the antifibrinolytic functions of healthy pregnant women are enhanced during early pregnancy, whereas the anticoagulation is slightly increased.
CONCLUSION: Coagulation, fibrinolysis, and antifibrinolysis remain at high levels, whereas the platelet activation remains at low levels during early pregnancy.
METHODS: One hundred and five pregnant women with monozygotic pregnancies between 10 and 12 weeks gestation were randomly enrolled as the study group, and another 82 non-pregnant women were selected as the control group. Coagulation parameters and prothrombotic state parameters were measured.
RESULTS: Fg, F1 + 2, thrombin-antithrombin complex, GMP140, D-dimer, and plasminogen activator inhibitor 2 were statistically different between the study and the control groups (p < 0.008). The coagulation, fibrinolytic, and the antifibrinolytic functions of healthy pregnant women are enhanced during early pregnancy, whereas the anticoagulation is slightly increased.
CONCLUSION: Coagulation, fibrinolysis, and antifibrinolysis remain at high levels, whereas the platelet activation remains at low levels during early pregnancy.
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