We have located links that may give you full text access.
JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Autologous stem cell therapy maintains vertebral blood flow and contrast diffusion through the endplate in experimental intervertebral disc degeneration.
Spine 2011 March 16
STUDY DESIGN: Experimental, controlled, randomized, and paired study.
OBJECTIVE: To evaluate regenerative effect of stem cell therapy on the vertebral endplate and introduce dynamic contrast-enhanced magnetic resonance imaging (MRI) as a tool in the investigation of endplate function.
SUMMARY OF BACKGROUND DATA: The vertebral endplate plays a crucial role in nutritional supply to the intervertebral disc. Estimation of endplate function is an important parameter in future biologic therapy of intervertebral disc degeneration (IDD).
METHODS: Four-level IDD was induced in each of 15 Gottingen minipigs. Percutaneous intradiscal injection of two hydrogels (Zimmer Biologics Inc, Austin, TX) and one loaded with stem cells was used as single interventions after 12 weeks. Total observation time was 24 weeks. MRI was performed before the initiation of treatment and killing of animals.
RESULTS: Three animals were excluded because of spondylodiscitis. Stem cell and hydrogel treatment had significantly higher T2 values, relative vertebral blood flow and volume, as well as lower Pfirrmann scores when compared with degenerative controls. No statistical differences were found compared to normal controls.
CONCLUSION: Stem cell and hydrogel therapy is able to partly regenerate IDD and maintain perfusion and permeability of the vertebral endplate and subchondral bone. Dynamic contrast-enhanced MRI may become an important tool in future investigation of the vertebral endplate.
OBJECTIVE: To evaluate regenerative effect of stem cell therapy on the vertebral endplate and introduce dynamic contrast-enhanced magnetic resonance imaging (MRI) as a tool in the investigation of endplate function.
SUMMARY OF BACKGROUND DATA: The vertebral endplate plays a crucial role in nutritional supply to the intervertebral disc. Estimation of endplate function is an important parameter in future biologic therapy of intervertebral disc degeneration (IDD).
METHODS: Four-level IDD was induced in each of 15 Gottingen minipigs. Percutaneous intradiscal injection of two hydrogels (Zimmer Biologics Inc, Austin, TX) and one loaded with stem cells was used as single interventions after 12 weeks. Total observation time was 24 weeks. MRI was performed before the initiation of treatment and killing of animals.
RESULTS: Three animals were excluded because of spondylodiscitis. Stem cell and hydrogel treatment had significantly higher T2 values, relative vertebral blood flow and volume, as well as lower Pfirrmann scores when compared with degenerative controls. No statistical differences were found compared to normal controls.
CONCLUSION: Stem cell and hydrogel therapy is able to partly regenerate IDD and maintain perfusion and permeability of the vertebral endplate and subchondral bone. Dynamic contrast-enhanced MRI may become an important tool in future investigation of the vertebral endplate.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app