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[Antidote against local anaesthetic intoxication: new use of lipid emulsion for intravenous administration]

Maarten ter Horst, Gilbert C H Tjiang, Ronald L Luitwieler, Chris van Velzen, Robert Jan Stolker, Marcel de Quelerij
Nederlands Tijdschrift Voor Geneeskunde 2010, 154: A1302
Local anaesthetics are routinely used for several indications, but despite local administration their use may lead to systemic toxicity. The symptoms include numbness of the tongue, dizziness, tinnitus, visual disturbances, muscle spasms, convulsions, coma, and respiratory and cardiac arrest. Recently, an intravenous lipid emulsion was reported to act as a novel potential antidote for systemic toxicity due to local anaesthetics. We describe the application of this lipid emulsion in a 27-year-old patient with generalized seizures and coma due to local anaesthetic toxicity. She recovered quickly and was responsive again 10 minutes after the intravenous administration of the lipid emulsion.


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