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JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
[Study on the preparation of sustained-release pellets containing active components from Gastrodia elata by fluid-bed coating].
OBJECTIVE: To study the formulation of sustained-release pellets containing active components from Gastrodia elata by coating in the fluid-bed.
METHODS: The sustained-release pellets were prepared with Eudragit RS 100. The formulation was optimized by the direct comparison. Then their properties were evaluated.
RESULTS: The pellets presented the perfect sphericity and narrow diameter distribution and the curve of their cumulative drug release was in accord with Higuchi equation.
CONCLUSION: The pellets have sustained-release effect in 12 hours.
METHODS: The sustained-release pellets were prepared with Eudragit RS 100. The formulation was optimized by the direct comparison. Then their properties were evaluated.
RESULTS: The pellets presented the perfect sphericity and narrow diameter distribution and the curve of their cumulative drug release was in accord with Higuchi equation.
CONCLUSION: The pellets have sustained-release effect in 12 hours.
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