Outcome of severe preeclampsia manifested as nephrotic syndrome.

OBJECTIVES: To discuss the clinical features of severe preeclampsia and its outcome manifested as nephrotic syndrome (NSP).

METHODS: Clinical data of 22 NSP patients treated in our hospital from January 2003 to March 2008 were collected to retrospectively analyze the blood pressure, serum albumin, urea nitrogen, cholesterol, 24 h urine protein, etc. before and after pregnancy.

RESULTS: (1) The outcome of pregnant women: the blood pressure of patients in all 22 cases recovered within 6 weeks; edema usually regressed within 6 weeks, however, only 1 patient recovered on week 10; urine protein usually disappeared within 6 weeks, however, it kept remaining in the urine of patients in 2 cases after 10 weeks; the recovery of blood lipid, serum uric acid and plasma albumin often occurred within 4-10 weeks, while only a few patients did not recover; no pregnant woman died, indicating good prognosis. (2) The outcome of perinatal infant: 7 perinatal infants died (31.8%), and 9 neonatal infants were asphyxiated (40.9%), and 15 neonatal infants with low weight were born (68.2%).

CONCLUSIONS: All indexes of NSP patients usually recovered within 6 weeks after pregnancy cessation.