We have located links that may give you full text access.
JOURNAL ARTICLE
RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
MHV-resistant SJL/J mice express a non-functional homolog to the MHV receptor glycoprotein.
MHV-A59 recognizes a 100-110 K glycoprotein receptor on intestinal and liver plasma membranes. The receptor protein was affinity purified using an anti-receptor monoclonal antibody. Purified receptor was sequenced from the 1st to the 15th amino acids. Antiserum raised against a synthetic peptide having this sequence bound to the 110 K receptor from BALB/c intestine and a 58 K fragment of the receptor. SJL/J mice are resistant to MHV-A59 and their plasma membranes were previously shown to lack binding to MHV. However, anti-peptide antibody bound to a 105 K protein and a 53 K protein fragment from SJL/J plasma membranes. These SJL/J proteins did not bind MHV or to the blocking monoclonal anti-receptor antibody. Genetic resistance of SJL/J mice to MHV-A59 appears to be due to mutation of the receptor glycoprotein resulting in a molecule that does not bind MHV.
Full text links
Related Resources
Trending Papers
Heart failure with preserved ejection fraction: diagnosis, risk assessment, and treatment.Clinical Research in Cardiology : Official Journal of the German Cardiac Society 2024 April 12
Proximal versus distal diuretics in congestive heart failure.Nephrology, Dialysis, Transplantation 2024 Februrary 30
World Health Organization and International Consensus Classification of eosinophilic disorders: 2024 update on diagnosis, risk stratification, and management.American Journal of Hematology 2024 March 30
Efficacy and safety of pharmacotherapy in chronic insomnia: A review of clinical guidelines and case reports.Mental Health Clinician 2023 October
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app