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Ultrasound-mediated oxygen delivery from chitosan nanobubbles.

Roberta Cavalli, Agnese Bisazza, Alessandro Rolfo, Sonia Balbis, Daniele Madonnaripa, Isabella Caniggia, Caterina Guiot
International Journal of Pharmaceutics 2009 August 14
Ultrasound (US) energy combined with gas-filled microbubbles has been used for several years in medical imaging. This study investigated the ability of oxygen-loaded chitosan bubbles to exchange oxygen in the presence or in the absence of US. Oxygen delivery is enhanced by sonication and both frequency and time duration of US affected the exchange kinetics.

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