We have located links that may give you full text access.
OLM interneurons are transiently recruited into field gamma oscillations evoked by brief kainate pressure ejections onto area CA1 in mice hippocampal slices.
Georgian Medical News 2009 Februrary
Oscillations (30-100 Hz) are correlated with the cognitive functions of the brain. In the hippocampus interactions between perisomatic and trilaminar interneurons with pyramidal cells are thought to underlie generation of field gamma oscillations. In area CA3 OLM interneurons receive synaptic input in gamma range but generate action potential (AP) output in theta band and are involved in theta oscillations synchronized along the longitudinal axis of the hippocampus. In slice preparations of CA3 area the spike timing of OLM cells could be modulated by carbachole induced gamma oscillations, although their firing rates are limited to theta frequency. Normally, OLM interneurons are somatostatin positive cells. In this study we tested whether parvalbumin (PV) containing OLM interneurons in area CA1 limit AP output during kainate pressure ejection also to theta frequency. We used focal short applications of kainate in area CA1 to induce filed gamma oscillations with an average frequency of about 44.7+/-4.4 Hz. The duration of field gamma was on average 8.9+/-3.5 s. During such oscillations CA1 PV positive OLM interneurons of mice hippocampus received excitatory synaptic input at gamma frequency. Moreover, their AP output was in gamma range as well. Thus, we show that beside the somatostatin containing OLM interneurons, which generate theta rhythm there are PV containing OLM cells, which could synchronize the distal dendrites of CA1 pyramidal cells to the field gamma oscillations.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Diagnosis and Management of Cardiac Sarcoidosis: A Scientific Statement From the American Heart Association.Circulation 2024 April 19
Essential thrombocythaemia: A contemporary approach with new drugs on the horizon.British Journal of Haematology 2024 April 9
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app