ENGLISH ABSTRACT
JOURNAL ARTICLE
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[Driving under the influence of amphetamine and metamphetamine].

BACKGROUND: The CNS stimulatory agents amphetamine and methamphetamine are often detected in blood samples from apprehended subjects driving under the influence of drugs.

MATERIAL AND METHODS: Relevant literature was identified through searches in PubMed and Google Scholar. The current state of knowledge regarding effects of amphetamines on traffic behaviour is reviewed and discussed.

RESULTS: Limited epidemiological data and a small number of experimental studies using low doses of amphetamines are available. Low amphetamine doses have been associated with enhanced performance in studies of sleep-deprived subjects. Theoretical considerations and empirical observations suggest that higher doses may impede performance, but not in accordance with usual concentration/effect relationships.

INTERPRETATION: There is a conspicuous lack of data on how to handle cases of driving under the influence of amphetamines.

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