[Study on the preparation of matrine-containing nanocell].

OBJECTIVE: To Study the preparation and optimization of matrine-containing nanocell.

METHODS: Using the film-ultrasonic method and global optimization algorithm to prepare and formulate matrine-containing nanocell. UV spectrophotometry was used to determine the entrapment efficiency of the astragalan. Laser beacon was used to determine the diameter distribution of the nanocells. Using the scanning probe microscope to observe the surface topography of the nanocell. Transmission electron microscope was used to inspect the core-shell structure of the nanocell.

RESULTS: The matrine-containing nanocells appeared to be round, integrated, well separated and uniform in size with high entrapment efficiency, the average particle size of the matrine-containing nanocells was 300 nm and the astragalan entrapment efficiency was above 90%. Preparation technology had fine reproducibility.

CONCLUSION: Using global optimization algorithm can prepare and optimize matrine-containing nanocell.