[Atopy and drug allergy].

UNLABELLED: The aim of our study is to show possible correlation between atopy and drug allergy, and the clinical manifestations of drug allergy that may have predictive value. There were 150 patients with positive history of drug allergy, ages 18-73 years. Cutaneous anr/or dose provocative testing was done, depending on the drug. Drug allergy was found in 58 patients (40%). There were 18 patients (12%) with atopic diathesis of which 9 (50%) were found to have drug allergy. Of 17 patients diagnosed as anaphylaxis, 13 (76%) had drug allergy, penicillin being the most common offending drug (7 parients). Of 75 patients diagnosed as urticaria, drug allergy was prouded in 36 (47%) patients. Positive drug allergy was found as follows (percentage wise): trimetoprim-sulfometoksazol 46% (13 tested, 6 positive); penicillin 35,8% (54 tested, 19 positive); noraminophenazone 31% (22 tested, 6 positive); muscle relaxants and general anaesthetics 26% (23 tested, 6 single positive).

CONCLUSIONS: Athophy is not predisposing factor for drug allergy; 60% of patients did not have drug allergy although stated in medical documents; anaphylaxis has the highest predictive value, followed by urticardia and fixed drug eruption (when trimetoprim-sulfometoxasol is concerned).