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JOURNAL ARTICLE
REVIEW
Intraoperative neurophysiologic monitoring for intramedullary spinal-cord tumor surgery.
Clinical Neurophysiology 2007 December
During resection of intramedullary spinal-cord tumors intraoperative neurophysiological monitoring has become a true surgical technology. Motor evoked potentials are the most important modality for this purpose. Its use requires neurophysiological expertise from the surgeon, and a monitoring team in place able to handle the necessary equipment. Motor potentials are evoked by transcranial electrical motor cortex stimulation. A "single stimulus technique" evokes D-waves recorded from the spinal cord. The "multipulse (or train) stimulation technique" evokes electromyographic responses in peripheral muscles. These are optimally recorded from the thenar, hypothenar, tibialis anterior, and flexor hallucis brevis muscles, which are known to have strong pyramidal innervation. D-wave monitoring looks primarily at the peak-to-peak amplitude. When monitoring muscle MEPs, the presence or absence of the response irrespective of stimulation intensity is the important parameter. Preparations for neurophysiological monitoring fit quite well into a neurosurgical operating room environment. Recording and interpretation of MEPs is fast and straightforward. Pre- and postoperative clinical motor findings correlate with intraoperative MEP results. Thus correct prediction of the clinical status at a given time during surgery is possible with a very high certainty. The sensitivity of muscle MEPs for postoperative motor deficits is nearly 100%, its specificity is about 90%. Thus MEP data indeed reflect the clinical "reality". Present and stable recordings document intact motor pathways and allow the surgeon to confidently proceed with a tumor resection. Loss of muscle MEPs and/or decrease of the D-wave amplitude constitutes a "window of warning". It reflects a pattern of MEP change indicating a reversible injury to the essential motor pathways. Using this information, the surgical strategy can be adapted before irreversible neurological damage is caused by the surgical manipulation. Such adaptation comprises simply waiting for the recordings to spontaneously improve again, irrigating with warm saline solution to wash out blocking potassium. Other measures include the elevation of mean arterial pressure to improve local perfusion. Even staged resection can be considered if intraoperative measures do not sufficiently improve the recordings.
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