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JOURNAL ARTICLE
REVIEW
N-acetylcysteine in the prevention of contrast-induced nephropathy.
BACKGROUND AND OBJECTIVES: Contrast-induced nephropathy (CIN) is a common clinical problem that is growing in importance as an increasing number of tests and procedures that utilize contrast media are performed.
DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: The biological and pharmacological properties of n-acetylcysteine (NAC) are reviewed, as well as the current literature relevant to the ability of NAC to prevent CIN.
RESULTS: After publication of a seminal study by Tepel et al. in 2000, there has been a surge in interest regarding the ability of NAC to reduce the risk for CIN. Since then a large number of studies, mostly with relatively small sample sizes, have been published.
CONCLUSIONS: The results have been remarkably varied with some studies finding great efficacy with NAC but most finding no significant benefit.
DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: The biological and pharmacological properties of n-acetylcysteine (NAC) are reviewed, as well as the current literature relevant to the ability of NAC to prevent CIN.
RESULTS: After publication of a seminal study by Tepel et al. in 2000, there has been a surge in interest regarding the ability of NAC to reduce the risk for CIN. Since then a large number of studies, mostly with relatively small sample sizes, have been published.
CONCLUSIONS: The results have been remarkably varied with some studies finding great efficacy with NAC but most finding no significant benefit.
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