[Effect of nitrogen oxide donor and inhibitor on some biochemical indices of the brain of intact rats and rats with subarachnoidal hemorrages].

An effect of nitrogen oxide donator Nebilet and inhibitor of NO-synthase L-Name in concentration 10(-4) and 10(-5) on some biochemical indices in vitro has been studied. It was established that an incubation of tissues with nitrogen oxide donator results in an increase of nitrits' level, some intensification of LPO and activation of antioxidant defense enzymes, especially in rats with SAH. On the contrary, an incubation of cerebral homogenate with inhibitor of NO-synthase L-NAME resulted in considerable lowering of nitrits' level, significant activation of LPO.