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JOURNAL ARTICLE
REVIEW
The pathophysiology of hepatic encephalopathy.
Nursing in Critical Care 2006 March
Hepatic encephalopathy (HE) is a complicated disorder, the pathophysiology of which remains to be fully understood. This article reviews the current main theories including the potential involvement of ammonia, gamma-aminobutyric acid (GABA)/benzodiazipines and false neurotransmitters. Each theory is critically examined with the evidence for each reviewed carefully, and the potential relationship of ammonia to the remaining two theories explored. Known preciptating factors of HE are also considered as evidence. The conclusions drawn from the evidence provided indicate the large role played by ammonia and suggest that this may be the key to understanding HE as science progresses.
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