Development of severe ovarian hyperstimulation syndrome after inadvertent stimulation with a gonadotropin-releasing hormone agonist and human menopausal gonadotropin in a pre-existing early pregnancy.

OBJECTIVE: To report a case of severe ovarian hyperstimulation syndrome (OHSS) after inadvertent GnRH long protocol/hMG stimulation in a pre-existing early pregnancy.

DESIGN: Case report.

SETTING: Private infertility clinic.

PATIENT(S): A 28-year-old woman who conceived spontaneously following IVF and cryo-embryo transfer (cryo-ET).

INTERVENTION(S): IVF/intracytoplasmic sperm injection (ICSI), cryo-ET, analgesia, and forced diuresis.

MAIN OUTCOME MEASURE(S): Viable pregnancy.

RESULT(S): Viable pregnancy with OHSS despite inadvertent administration of GnRH-agonist, stimulation with hMG, and ET in a pre-existing pregnancy.

CONCLUSION(S): Observation of follicle development following stimulation during pregnancy with low quantity and poor quality oocytes combined with abnormal endometrium.