Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility.

Xiaosong Wang, Massimiliano Ria, Peter M Kelmenson, Per Eriksson, David C Higgins, Ann Samnegård, Christina Petros, Jarod Rollins, Anna M Bennet, Björn Wiman, Ulf de Faire, Charlotte Wennberg, Per G Olsson, Naoto Ishii, Kazuo Sugamura, Anders Hamsten, Kristina Forsman-Semb, Jacob Lagercrantz, Beverly Paigen

Nature Genetics 2005 April

Ath1 is a quantitative trait locus on mouse chromosome 1 that renders C57BL/6 mice susceptible and C3H/He mice resistant to diet-induced atherosclerosis. The quantitative trait locus region encompasses 11 known genes, including Tnfsf4 (also called Ox40l or Cd134l), which encodes OX40 ligand. Here we report that mice with targeted mutations of Tnfsf4 had significantly (P

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