We have located links that may give you full text access.
Journal Article
Research Support, Non-U.S. Gov't
Review
Drug targets in malaria parasites.
Malaria ranks with tuberculosis and AIDS in terms of its ability to destroy human health. In India there are at least two million cases seen annually. Although mortality may not be as high as it is in Africa, the trauma due to morbidity and debility and loss of productive man hours are colossal. Since resistance to chloroquine and antifolates is spreading rapidly, there is need to develop new pharmacophores, for which identification of new drug targets is essential. This review focuses on targets arising from classical and unique metabolic pathways in the malaria parasite, highlighting the research being carried out in India in the context of the global scenario. A significant amount of research in India and elsewhere has provided new knowledge on parasite biology, that could pave the way for the development of new pharmacophores. However, it is a matter of regret to record that malaria being a poor man's disease does not enthuse pharmaceutical companies in general to invest and bring out new molecules. Developing countries like India should take a lead in developing new but affordable antimalarials.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app