We have located links that may give you full text access.
CLINICAL TRIAL
ENGLISH ABSTRACT
JOURNAL ARTICLE
[Therapeutic effects of prostaglandin E1 in diabetic patients].
Minerva Cardioangiologica 2003 June
AIM: The therapeutic effect of prostaglandin E1 in 26 diabetic patients with symptomatic and disabling neuropathy has been examined. Authoritative experiments in the literature describe the potential coexistence, in diabetic neuropathy, of vascular and metabolic deficiencies that may justify the use of vasodilators.
METHODS: The biological effect of PGE1 seems to meet these requirements; it has in fact a multifactorial action mechanism, c-AMP mediated, selectively acting on the microvascular district improving the tissular perfusion and favouring an aerobic metabolism. In diabetics suffering from neuropathy, a reduction of psychophysical and working abilities due to chronicity of pain, sensitive disorders and hyposthenia with early muscular fatigability is often detectable. It is not difficult to imagine how heavily this pathology can affect the quality of life in patients of different ages and social conditions.
RESULTS: The results of our studies confirm the possibility of a direct relation between microvascular damage and interference with the normal nervous tissue conduction, as described in the literature. After a 4-week therapy, data obtained from electrophysiologic and vibrometric tests show in many diabetic patients a significant functional improvement in the peripheral nervous system and, in more than 90% of the cases, of neurological symptomatology.
CONCLUSION: The methods needed to standardize therapeutic protocols are still to be verified, keeping in mind that the persistence of physiopathologic factors responsible for neurophathy may lead to the risk of relapses.
METHODS: The biological effect of PGE1 seems to meet these requirements; it has in fact a multifactorial action mechanism, c-AMP mediated, selectively acting on the microvascular district improving the tissular perfusion and favouring an aerobic metabolism. In diabetics suffering from neuropathy, a reduction of psychophysical and working abilities due to chronicity of pain, sensitive disorders and hyposthenia with early muscular fatigability is often detectable. It is not difficult to imagine how heavily this pathology can affect the quality of life in patients of different ages and social conditions.
RESULTS: The results of our studies confirm the possibility of a direct relation between microvascular damage and interference with the normal nervous tissue conduction, as described in the literature. After a 4-week therapy, data obtained from electrophysiologic and vibrometric tests show in many diabetic patients a significant functional improvement in the peripheral nervous system and, in more than 90% of the cases, of neurological symptomatology.
CONCLUSION: The methods needed to standardize therapeutic protocols are still to be verified, keeping in mind that the persistence of physiopathologic factors responsible for neurophathy may lead to the risk of relapses.
Full text links
Related Resources
Trending Papers
Heart failure with preserved ejection fraction: diagnosis, risk assessment, and treatment.Clinical Research in Cardiology : Official Journal of the German Cardiac Society 2024 April 12
Proximal versus distal diuretics in congestive heart failure.Nephrology, Dialysis, Transplantation 2024 Februrary 30
Efficacy and safety of pharmacotherapy in chronic insomnia: A review of clinical guidelines and case reports.Mental Health Clinician 2023 October
World Health Organization and International Consensus Classification of eosinophilic disorders: 2024 update on diagnosis, risk stratification, and management.American Journal of Hematology 2024 March 30
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app