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The effect of the publication of a major clinical trial in a high impact journal on clinical practise: the ORACLE Trial experience.

OBJECTIVE: To estimate the short term effect of the publication of a major clinical trial on clinical practise.

DESIGN: Questionnaire survey of clinical practise.

SETTING: UK.

POPULATION: All maternity units in the UK.

METHOD: A self-administered questionnaire completed by lead consultants on delivery suite of maternity units.

MAIN OUTCOME MEASURES: Changes in antibiotic prescription.

RESULTS: Within six months of publication, approximately 50% of maternity units had changed their guidelines for the care of women with preterm prelabour rupture of the fetal membranes.

CONCLUSION: Publication of a major clinical trial does impact on clinical practise but the impact is heterogeneous in terms of time and consistency.

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