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[Preparation, characterization and drug release characteristics of poly(lactide)(PL)/poly(lactide-co-polyethylene glycol)(PLEG) blend microspheres].
PL and PLEG are biodegradable, biocompatible polymers. They have been widely used for controlled release of drugs. We synthesized PLEG copolymers containing PEG segments with various molecular weight and prepared hCG-loaded PL/PLEG blend microspheres to improve hCG entrapment efficiency. It was shown that the hCG entrapment effciency of PL/PLEG microspheres was higher than that of PL or PLEG microspheres when P(L-co-PEG6000)(90:10) was used. In vitro release test showed that the release of hCG was a burst-slow process, which was thought to be good for antigens to produce antibodies.
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