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English Abstract
Journal Article
Research Support, Non-U.S. Gov't
[Melatonin inhibits TRH-stimulating prolactin gene expression of anterior pituitary cells in newborn rat in vitro].
OBJECTIVE AND METHODS: This work was to investigate whether melatonin (MEL) plays a role in the gene expression of prolactin (PRL), by the Method of in situ hybridyzation.
RESULTS: Our results indicated that, at a higher concentration, MEL not only inhibits TRH (thyrotropin releasing hormone) stimulating PRL gene expression of anterior pituitary cell in newborn rat, but also exerts a direct inhibitory effect on PRL gene expression in vitro.
CONCLUSION: These results suggest that MEL may be a regulator of PRL synthesis and secreting in vivo.
RESULTS: Our results indicated that, at a higher concentration, MEL not only inhibits TRH (thyrotropin releasing hormone) stimulating PRL gene expression of anterior pituitary cell in newborn rat, but also exerts a direct inhibitory effect on PRL gene expression in vitro.
CONCLUSION: These results suggest that MEL may be a regulator of PRL synthesis and secreting in vivo.
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