Psychopharmacologic Management of Psychiatric Disorders in Patients with Diabetes Mellitus.

Diabetes mellitus is accompanied by multiple complications involving multiple organ systems. The Diabetes Control and Complication Trial (DCCT) has established the impact of intensive control in the emergence and progression of diabetic complications. Psychiatric disorders in patients with diabetes present a significant challenge and obstacle to glycemic control, and are a source of significant challenge and obstacle to glycemic control, and are a source of significant distress. Psychopharmacologic management of these disorders requires attention to their potential side effects, interactions with other agents, and the impact of psychopharmacologic management on glycemic control. Unfortunately, data regarding the direct impact, benefits and risks of psychopharmacologic agents are largely based on clinical experience and few controlled studies. General principles regarding the management of psychiatric disorders in the "medically-ill" need to be considered along with available data regarding the impact of psychopharmacologic interventions in patients with diabetes.