Yuanzhuang Zhang, Yeqiu Xu, Yuxin Bao, Yinzhou Luo, Guanzhen Qiu, Ming He, Jie Lu, Jian Xu, Bin Chen, Yong Wang
Osteosarcoma, originating from primitive bone-forming mesenchymal cells, is the most common malignant bone tumour among children and adolescents. N6-methyladenosine (m6A), the most ubiquitous type of posttranscriptional modification, is a methylation that occurs in the N6-position of adenosine. m6A dramatically affects the splicing, export, translation, and stability of various RNAs, including mRNA and noncoding RNAs (ncRNAs). Increasing evidence suggests that ncRNAs, especially microRNAs (miRNA), long noncoding RNAs (lncRNA), and circular RNAs (circRNAs), regulate the m6A modification process by affecting the expression of m6A-associated enzymes...
December 2023: Epigenetics: Official Journal of the DNA Methylation Society