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lncRNA and Osteosarcoma

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https://www.readbyqxmd.com/read/27860482/long-noncoding-rna-ewsat1-promotes-osteosarcoma-cell-growth-and-metastasis-through-suppression-of-meg3-expression
#1
Lishan Sun, Cheng Yang, Juan Xu, Yanhong Feng, Liguo Wang, Tao Cui
Osteosarcoma (OS) is the most common primary bone tumor in children and adolescents. Long noncoding RNAs (lncRNAs) are a class of transcriptional products of the genome without protein-coding potential. Recently, lncRNA Ewing sarcoma-associated transcript 1 (EWSAT1) was functionally identified in Ewing sarcoma, a highly aggressive primary pediatric bone tumor. However, whether EWSAT1 plays a role in OS remains unclear. In the present study, gain- and loss-of-function assays demonstrated that EWSAT1 enhanced OS cell proliferation, migration, and invasion...
December 2016: DNA and Cell Biology
https://www.readbyqxmd.com/read/27829995/long-noncoding-rna-zeb1-as1-acts-as-an-oncogene-in-osteosarcoma-by-epigenetically-activating-zeb1
#2
Chibo Liu, Jianjun Lin
Long noncoding RNAs (lncRNAs) have been demonstrated to be dysregulated in many disease states and have pivotal roles in various pathophysiological processes. However, the expression, roles and potential mechanism of lncRNA ZEB1-AS1 in osteosarcoma are still unknown. In this study, we measured ZEB1-AS1 expression and the results showed that ZEB1-AS1 was upregulated in osteosarcoma tissues and cells. Increased expression of ZEB1-AS1 is correlated with larger tumor size, progressed Enneking stage, tumor metastasis, worse recurrence-free and overall survival of osteosarcoma patients...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27813492/long-non-coding-rna-pvt1-promotes-osteosarcoma-development-by-acting-as-a-molecular-sponge-to-regulate-mir-195
#3
Quan Zhou, Fengli Chen, Jiali Zhao, Baojun Li, Yong Liang, Wei Pan, Shaoxian Zhang, Xinhong Wang, Donghui Zheng
A growing body of evidence has indicated that long non-coding RNAs (lncRNAs) serve as competing endogenous RNAs (ceRNAs) during oncogenesis. In this study, the qRT-PCR results indicated that the lncRNA PVT1 is overexpressed in osteosarcoma and decreased the survival rate of osteosarcoma patients. MTT and clonal colony formation assays were used to detect the effect of PVT1 on proliferation, and flow cytometry was performed to assess apoptosis and the cell cycle. A Transwell assay was used to analyze migration and invasion...
November 2, 2016: Oncotarget
https://www.readbyqxmd.com/read/27706792/retraction-of-articles-with-plagiarism-in-common-with-other-publications
#4
(no author information available yet)
The GMR editorial staff was alerted about some manuscripts that were found to be substantially equal. The Publisher and Editor decided to retract these articles in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation, we have strong reason to believe that the peer review process was failure and, after review and contacting the authors, the editors of Genetics and Molecular Research decided to retract these articles. The authors and their institutions were advised of this serious breach of ethics...
September 30, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27660759/role-of-long-noncoding-rna-hotair-in-the-growth-and-apoptosis-of-osteosarcoma-cell-mg-63
#5
Hua Zheng, Jing Min
This study investigated the function of HOTAIR in the growth and apoptosis of OS MG-63 cell line in vitro and further clarified its mechanism. The expression levels of HOTAIR in OS MG-63 cell line and normal osteoblast hFOB1.19 cell line were determined by RT-PCR, respectively. The growth and apoptosis of MG-63 cells in vitro were investigated by MTT assay and flow cytometry assay after HOTAIR was knocked down with retroviral vector construction. And the expression levels of cell growth and apoptosis related factors TGF-β, p53, Bcl-2, and TNF-α were determined to clarify the mechanism...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27658774/long-non-coding-rna-tug1-contributes-to-tumorigenesis-of-human-osteosarcoma-by-sponging-mir-9-5p-and-regulating-pou2f1-expression
#6
Chu-Hai Xie, Yan-Ming Cao, Yan Huang, Qun-Wei Shi, Jian-Hong Guo, Zi-Wen Fan, Ju-Gen Li, Bin-Wei Chen, Bo-Yi Wu
Recent studies have shown that long non-coding RNAs (lncRNAs) have critical roles in tumorigenesis, including osteosarcoma. The lncRNA taurine-upregulated gene 1 (TUG1) was reported to be involved in the progression of osteosarcoma. Here, we investigated the role of TUG1 in osteosarcoma cells and the underlying mechanism. TUG1 expression was measured in osteosarcoma cell lines and human normal osteoblast cells by quantitative real-time PCR (qRT-PCR). The effects of TUG1 on osteosarcoma cells were studied by RNA interference in vitro and in vivo...
September 22, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27649655/long-non-coding-rna-malat1-is-an-independent-prognostic-factor-of-osteosarcoma
#7
K-T Gao, D Lian
OBJECTIVE: Accumulating evidence revealed that long non-coding RNAs (lncRNAs) were emerging regulators in cancer biology, and could be used as potential biomarkers for cancer prognosis. In this study, we focused on MALAT1 and investigated its expression pattern, clinical significance in osteosarcoma. PATIENTS AND METHODS: The expression of lncRNA MALAT1 was analyzed in 162 osteosarcoma tissues by quantitative real-time PCR (qRT-PCR). Then, we explored the potential relationship between MALAT1 expression levels in tumor tissues and clinicopathological features of osteosarcoma, and clinical outcome...
September 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27648140/upregulation-of-lncrna-hnf1a-as1-promotes-cell-proliferation-and-metastasis-in-osteosarcoma-through-activation-of-the-wnt-%C3%AE-catenin-signaling-pathway
#8
Hongxing Zhao, Wengen Hou, Jingang Tao, Yilei Zhao, Guang Wan, Chao Ma, Haibin Xu
HNF1A-antisense 1 (HNF1A-AS1), a long non-coding RNA (lncRNA), is associated with metastasis and is an independent prognostic factor for lung cancer. Recent studies demonstrated that HNF1A-AS1 play important roles in cacinogenesis. However, the exact effects and molecular mechanisms of HNF1A-AS1 in osteosarcoma (OS) progression is still unclear. In the present study, we found that HNF1A-AS1 was markedly up-regulated in OS tissues compared to their adjacent non-tumor tissues. HNF1A-AS1 expression levels were positively associated with the clinical stage, distant metastasis, and reduced overall survival of OS patients...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27623205/combined-over-expression-of-the-hypoxia-inducible-factor-2%C3%AE-gene-and-its-long-non-coding-rna-predicts-unfavorable-prognosis-of-patients-with-osteosarcoma
#9
Wei Li, Xijing He, Rongliang Xue, Ying Zhang, Xiaoqin Zhang, Jianrui Lu, Zhenni Zhang, Li Xue
BACKGROUND: LncRNA hypoxia-inducible factor-2α (HIF-2α) promoter upstream transcript (HIF2PUT) functions as a novel regulatory factor of osteosarcoma stem cells partly by controlling HIF-2α expression. The aim of this study was to investigate the clinical significance of HIF-2α and HIF2PUT in human osteosarcoma. MATERIALS AND METHODS: Quantitative real-time PCR was performed to detect the expression levels of HIF-2α mRNA and HIF2PUT in 82 surgical specimens of primary osteosarcoma and matched non-cancerous bone tissues...
June 27, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27609068/long-non-coding-rna-linc00161-sensitises-osteosarcoma-cells-to-cisplatin-induced-apoptosis-by-regulating-the-mir-645-ifit2-axis
#10
Yuan Wang, Li Zhang, Xifu Zheng, Weiliang Zhong, Xiliang Tian, Baosheng Yin, Kang Tian, Weiguo Zhang
Chemotherapeutic insensitivity remains a major obstacle to osteosarcoma treatment. Recently, increasing evidence has suggested that long non-coding RNAs (lncRNAs) play an essential role in tumourigenesis. However, the potential biological roles and regulatory mechanisms of novel lncRNAs in response to cisplatin treatment are poorly understood. Here, we found that lncRNA LINC00161 was induced by cisplatin in osteosarcoma cells. Elevated LINC00161 increased cisplatin-induced apoptosis and reversed the cisplatin-resistant phenotype of osteosarcoma cells by upregulating IFIT2...
September 5, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27513470/overexpression-of-long-non-coding-rna-mfi2-promotes-cell-proliferation-and-suppresses-apoptosis-in-human-osteosarcoma
#11
Zhixun Yin, Hongmei Ding, Erming He, Jingmhen Chen, Ming Li
The long non-coding RNA MFI2 antisense RNA is overexpressed in human cancer tissues and its increased expression is associated with occurrence and metastasis of cancer. However, the underlying mechanism in evolution and progression of human osteosarcoma is not well known. In the present study, we aimed to evaluate the molecular mechanism of lncRNA MFI2 in promoting osteosarcoma cell proliferation and suppressing apoptosis. We found that the lncRNA MFI2 was significantly overexpressed in human osteosarcoma tissues...
October 2016: Oncology Reports
https://www.readbyqxmd.com/read/27460090/long-noncoding-rna-bcar4-promotes-osteosarcoma-progression-through-activating-gli2-dependent-gene-transcription
#12
Fenyong Chen, Jiadong Mo, Li Zhang
Despite great advances have been made in the understanding of biology of osteosarcoma, the molecular mechanisms involved in osteosarcoma tumorigenesis and progression are still largely unknown. Long noncoding RNA (lncRNA) is a new type of RNA molecule, which plays pivotal roles in many tumors. lncRNA BCAR4 has been identified as an oncogenetic lncRNA involved in the progression of breast cancer. However, the functions and clinical significances of BCAR4 in osteosarcoma are unknown now. In this study, we found that BCAR4 was significantly upregulated in osteosarcoma tissues...
July 27, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27458156/malat1-promotes-osteosarcoma-development-by-targeting-tgfa-via-mir376a
#13
Wei Luo, Hongbo He, Wenfeng Xiao, Qing Liu, Zhenhan Deng, Yaojuan Lu, Qian Wang, Qiping Zheng, Yusheng Li
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long non-coding RNA (lncRNA) that contributes to the initiation and development of many solid tumors, including osteosarcoma (OS). Here, we showed that MALAT1 was increased in human OS cell lines and tissues and promoted OS cell growth, while MALAT1 knockdown suppressed OS cell growth. We also detected downregulation of MIR376A, a suppressor of OS growth, and upregulation of TGFA, a promoter of OS growth, in OS tissues. TGFA expression was positively correlated with MALAT1 expression, and both were negatively correlated with MIR376A expression...
July 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27347346/overexpression-of-long-non-coding-rna-hottip-increases-chemoresistance-of-osteosarcoma-cell-by-activating-the-wnt-%C3%AE-catenin-pathway
#14
Zhenwei Li, Liang Zhao, Qiugen Wang
Long non-coding RNAs (lncRNAs) have been identified as oncogenes or tumor suppressors that are involved in tumorigenesis and chemotherapy resistance. HOTTIP is located at the 5' tip of the HOXA locus and coordinates the activation of multiple 5' HOXA genes, which plays an important role in multiple cancers. However, its biological role in the development of the chemoresistance phenotype of osteosarcoma (OS) is still unknown. In this study, we explored the roles of lncRNA HOTTIP in the initiation and chemoresistance of OS...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27339553/tug1-a-pivotal-oncogenic-long-non-coding-rna-of-human-cancers
#15
REVIEW
Zheng Li, Jianxiong Shen, Matthew T V Chan, William Ka Kei Wu
Long non-coding RNAs (lncRNAs) are a group greater than 200 nucleotides in length. An increasing number of studies has shown that lncRNAs play important roles in diverse cellular processes, including proliferation, differentiation, apoptosis, invasion and chromatin remodelling. In this regard, deregulation of lncRNAs has been documented in human cancers. TUG1 is a recently identified oncogenic lncRNA whose aberrant upregulation has been detected in different types of cancer, including B-cell malignancies, oesophageal squamous cell carcinoma, bladder cancer, hepatocellular carcinoma and osteosarcoma...
August 2016: Cell Proliferation
https://www.readbyqxmd.com/read/27335776/overexpression-of-lncrna-uca1-promotes-osteosarcoma-progression-and-correlates-with-poor-prognosis
#16
Wei Li, Peng Xie, Wen-Hui Ruan
Long non-coding RNAs (lncRNAs) have been proved to play important roles in the tumorigenesis and development of several human malignancies. Our study aims to investigate the expression and function of lncRNA-UCA1 in osteosarcoma. lncRNA-UCA1 expression was detected in osteosarcoma tissues and cell lines by using qRT-PCR. Association between lncRNA-UCA1 levels and clinicopathological factors and patient's prognosis was analyzed. The roles of lncRNA-UCA1 in regulating osteosarcoma cell proliferation, apoptosis, migration, and invasion were evaluated in vitro...
June 2016: Journal of Bone Oncology
https://www.readbyqxmd.com/read/27186302/mir-141-modulates-osteoblastic-cell-proliferation-by-regulating-the-target-gene-of-lncrna-h19-and-lncrna-h19-derived-mir-675
#17
Peiheng He, Ziji Zhang, Guangxin Huang, Hua Wang, Dongliang Xu, Weiming Liao, Yan Kang
Increasing evidence has reported the significant roles of lncRNA or miRNAs in the biology of various diseases. This study was aimed to elucidate the potential roles of miR-141 and lncRNA H19 and H19-derived miR-675 in regulating osteoblasts proliferation and apoptosis and to explore its potential mechanism. miR-141 mimic or miR-141 inhibitor or siRNA-H19 or miR-675 inhibitor was transfected into human hFOB1.19 cells. The effects or miR-141 expression on H19 or miR-675 expression, on osteoblasts proliferation and apoptosis were analyzed...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27051014/increased-expression-of-the-lncrna-bancr-and-its-prognostic-significance-in-human-osteosarcoma
#18
Z Q Peng, R B Lu, D M Xiao, Z M Xiao
Long noncoding RNAs (lncRNAs) play important roles in the formation and progression of many types of human malignancies. The aim of our study was to investigate the expression and biological functions of the lncRNA BRAF-activated noncoding RNA (BANCR) in human osteosarcoma. BANCR expression was quantified by real-time PCR in human osteosarcoma cell lines and tissues. We analyzed the association between BANCR levels and clinicopathological factors and patient prognosis. MTT, flow cytometric, and transwell invasion assays were performed to observe the effects of BANCR on MG-63 cell biological behaviors...
March 28, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27022737/long-noncoding-rna-fgfr3-as1-promotes-osteosarcoma-growth-through-regulating-its-natural-antisense-transcript-fgfr3
#19
Jiabing Sun, Xuming Wang, Chunjiang Fu, Xiaoyu Wang, Jilong Zou, Hanbing Hua, Zhenggang Bi
Long noncoding RNAs (lncRNAs), a new class of RNAs with no protein-coding potential, have been reported to have crucial roles in the regulation of a variety of tumors. However, the functions and molecular mechanisms of lncRNAs to osteosarcoma are still largely unknown. The purpose of this study is to examine the expression, functions and molecular mechanisms of a new lncRNA FGFR3 antisense transcript 1 (FGFR3-AS1) in osteosarcoma. The expression of FGFR3-AS1 was examined by real-time quantitative PCR. The regulation of FGFR3 by FGFR3-AS1 was examined by RNase protection assay, real-time quantitative PCR, western blotting, and luciferase reporter assay...
May 2016: Molecular Biology Reports
https://www.readbyqxmd.com/read/26986815/antidifferentiation-noncoding-rna-regulates-the-proliferation-of-osteosarcoma-cells
#20
Li Min, Song Hong, Hong Duan, Yong Zhou, Wenli Zhang, Yi Luo, Rui Shi, Chongqi Tu
BACKGROUND: Antidifferentiation noncoding RNA (ANCR), a newly identified long noncoding RNA (lncRNA), plays a critical role for stem cells to maintain undifferentiated cell state. However, the functions of ANCR in human cancers have not been reported. This study is designed to explore the role of ANCR in osteosarcoma. METHODS: Lentivirus-mediated (shRNA) was applied to silence ANCR in the human osteosarcoma cell lines U2OS and Saos-2. Cell viability was measured by MTT assay...
March 2016: Cancer Biotherapy & Radiopharmaceuticals
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