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lncRNA and Osteosarcoma

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https://www.readbyqxmd.com/read/29328452/hif%C3%A2-1%C3%AE-%C3%A2-induced-upregulation-of-lncrna-uca1-promotes-cell-growth-in-osteosarcoma-by-inactivating-the-pten-akt-signaling-pathway
#1
Tengfei Li, Yang Xiao, Tunsheng Huang
Increasing evidence indicates that long non‑coding RNAs (lncRNAs) play an important role in multiple biological processes including cell growth, differentiation, proliferation and invasion. Urothelial carcinoma associated 1 (UCA1) is a highly conserved nuclear ncRNA and a key regulator of cell proliferation and apoptosis in several types of cancers. However, its role in osteosarcoma progression is not well known. In the present study, we aimed to determine the biological role of UCA1 in osteosarcoma progression...
January 3, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29323740/long-non-coding-rna-asbel-promotes-osteosarcoma-cell-proliferation-migration-and-invasion-by-regulating-microrna-21
#2
Jianhui Zhao, Zhongli Gao, Chao Zhang, Han Wu, Rui Gu, Rui Jiang
Osteosarcoma is the most common malignant bone tumor in children and adolescents with high rate of incidence, high frequency of recurrence and high degree of metastasis. This study aimed to investigate the effects of long noncoding RNA antisense ncRNA in the Abundant in neuroepithelium area (ANA)/B-cell translocation gene 3 (BTG3) locus (lncRNA ASBEL) on the pathogenesis of osteosarcoma. The expression levels of ASBEL in human osteoblast cells and human osteosarcoma cells were evaluated using qRT-PCR. Effects of ASBEL knockdown on cell viability, migration and invasion were detected using trypan blue exclusion assay, cell migration and invasion assay, respectively...
January 11, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29291409/long-noncoding-rna-pcat-1-acts-as-an-oncogene-in-osteosarcoma-by-reducing-p21-levels
#3
Jiang Huang, Gaorong Deng, Tianmi Liu, Wenzhao Chen, Yang Zhou
Long non-coding RNA (lncRNA) is emerging as a critical regulator in multiple cancers. Recently, lncRNA PCAT-1 was found to be up-regulated in prostate cancer and hepatocellular carcinoma, exerting oncogenic effects. However, the biological function and regulatory mechanism of PCAT-1 remain unclear in osteosarcoma (OS). In this study, we reported that PCAT-1 expression was also upregulated in OS tissues, and its overexpression was remarkably associated with tumor size, Enneking stage, tumor node metastasis (TNM) stage and metastasis in patients with OS...
December 29, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29290978/long-noncoding-rna-malat1-promotes-cell-proliferation-through-suppressing-mir-205-and-promoting-smad4-expression-in-osteosarcoma
#4
Qingbo Li, Xiaohan Pan, Xiqian Wang, Xiejia Jiao, Jiachun Zheng, Zhiqiang Li, Yanqing Huo
Increasing evidences have indicated that long non-coding RNAs (lncRNAs) play an important role in multiply biological processes including cell development, differentiation, proliferation and invasion. The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), is a highly conserved nuclear ncRNA and a key regulator of metastasis development in several cancers. However, its role in osteosarcoma progression is not well known. In this study, we sought to determine the clinical and bilogical role of MALAT1 in osteosarcoma progression...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29290771/targeting-lncrna-malat1-suppresses-the-progression-of-osteosarcoma-by-altering-the-expression-and-localization-of-%C3%AE-catenin
#5
Zhi-Chang Zhang, Chun Tang, Yang Dong, Jing Zhang, Ting Yuan, Xiao-Lin Li
Osteosarcoma (OS), which affects adolescents especially during a growth spurt, has the highest incidence of any primary malignant bone tumour, and a high rate of early metastasis leading to a very poor prognosis. In recent years, non-coding RNAs, especially long non-coding RNAs (lncRNAs) have attracted more and more attention as novel epigenetic regulators in a variety of tumours, including OS. Most recently, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) was found to play an important role in OS progression by modulating the enhancers of zeste homolog 2 (EZH2)...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29285059/long-noncoding-rna-hotair-promotes-the-proliferation-and-metastasis-of-osteosarcoma-cells-through-the-akt-mtor-signaling-pathway
#6
Enqi Li, Zhe Zhao, Baotong Ma, Jinli Zhang
It has been proven that long non-coding (lnc)RNAs serve an important role in the tumorigenesis and development of several types of human malignancy. Previous studies have demonstrated that the lncRNA Hox transcript antisense intergenic RNA (HOTAIR) is involved in the development various types of cancer, including osteosarcoma (OS). However, the underlying mechanisms by which it has an affect are still largely unknown. In the present study, it was observed that the expression of HOTAIR was significantly upregulated in OS tissues compared to matched adjacent normal tissues, using reverse transcription-quantitative polymerase chain reaction analysis...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29275200/long-non-coding-rna-ccal-promotes-hepatocellular-carcinoma-progression-by-regulating-ap-2%C3%AE-and-wnt-%C3%AE-catenin-pathway
#7
Yu Liu, Ye Yang, Tianlong Wang, Li Wang, Xin Wang, Tiemin Li, Yue Shi, Yawei Wang
OBJECTIVE: Long non-coding RNAs are emerging as key molecules in cancer progression. LncRNA-CCAL has shown to be highly expressed and important in regulating CRC and osteosarcoma development. Nevertheless, the expression and mechanism of CCAL in HCC is still not well understood. METHODS: qRT-PCR and ISH were used to evaluate CCAL expression in HCC tissues and cell lines. Histone H3 methylation and acetylation levels across CCAL promoter region were examined by chromatin immunoprecipitation assays...
December 21, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29246789/lncrna-crnde-promotes-osteosarcoma-cell-proliferation-invasion-and-migration-by-regulating-notch1-signaling-and-epithelial-mesenchymal-transition
#8
Zheng Li, Yonghua Tang, Wujun Xing, Wei Dong, Zhichou Wang
Osteosarcoma is the most common bone malignancy in adolescence. Recently, the long non-coding RNAs (lncRNAs) were reported to play important roles in osteosarcoma progression. The present study examined the potential role of the lncRNA, Colorectal Neoplasia Differentially Expressed (CRNDE) and molecular mechanisms underlying osteosarcoma progression. In the present study, we identified that CRNDE was up-regulated in osteosarcoma tissues and cell lines, and CRNDE expression level was significantly higher in osteosarcoma tissues from patients with advanced stage and metastasis...
December 12, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29229388/lncrna-snhg12-promotes-tumorigenesis-and-metastasis-in-osteosarcoma-by-upregulating-notch2-by-sponging-mir-195-5p
#9
Sheng Zhou, Ling Yu, Min Xiong, Guo Dai
Osteosarcoma is the most common primary malignant bone tumor and has a high fatality rate in children and adolescents. Recently, an increasing amount of evidence has demonstrated that lncRNAs have crucial roles in regulating biological characteristics in malignant tumors. Therefore, this research was carried out to uncover the biological function and the potential molecular mechanism of SNHG12 in osteosarcoma. In this study, we found that SNHG12 was significantly upregulated in both osteosarcoma tissues and cell lines and osteosarcoma patients with high levels of SNHG12 tended to have a poor prognosis...
December 9, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29226461/long-non-coding-pandar-as-a-novel-biomarker-in-human-cancer-a-systematic-review
#10
REVIEW
Yifan Zou, Yuantang Zhong, Junjie Wu, Huizhong Xiao, Xintao Zhang, Xinhui Liao, Jianfa Li, Xuhua Mao, Yuchen Liu, Fuyou Zhang
OBJECTIVES: Long non-coding RNAs (lncRNAs) are characterized as a group of RNAs that more than 200 nucleotides in length and have no protein-coding function. More and more evidences provided that lncRNAs serve as key molecules in the development of cancer. Deregulation of lncRNAs functions as either oncogenes or tumour suppressor genes in various diseases. Recently, increasing studies about PANDAR in cancer progression were reported. In our review, we will focus on the current research on the character of PANDAR include the clinical management, tumour progression and molecular mechanisms in human cancers...
December 10, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/29209144/targeting-the-long-noncoding-rna-malat1-blocks-the-pro-angiogenic-effects-of-osteosarcoma-and-suppresses-tumour-growth
#11
Zhi-Chang Zhang, Chun Tang, Yang Dong, Jing Zhang, Ting Yuan, Shi-Cong Tao, Xiao-Lin Li
Osteosarcoma (OS), the commonest primary malignant tumour originating from bone, affects a substantial number of people, mostly during adolescent growth, and leads to a very poor prognosis as a result of the high rate of early metastases. Consequently, there is urgent demand for a novel treatment for this disease. There are growing concerns focused on OS-induced pro-angiogenic effects, but to date, the mechanism of OS-induced pro-angiogenesis is still insufficiently well-understood. Long noncoding RNAs (lncRNAs) have attracted increasing interest due to their strong correlation with a variety of diseases and their powerful capacity for epigenetic regulation...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29198132/meg3-long-non-coding-rna-prevents-cell-growth-and-metastasis-of-osteosarcoma
#12
S Z Zhang, L Cai, B Li
OBJECTIVE: This study aimed to investigate the role of long non-coding RNA MEG3 (lncRNA MEG3) in osteosarcoma (OS) and further explore the underlying molecular mechanism. MATERIALS AND METHODS: The expression profiles of MEG3 in OS cell lines and normal osteoblast cell line were detected by qRT-PCR. MEG3 was over-expressed in OS cell line by using LV-MEG3. MTT and colony-formation assays were applied for cell proliferation analysis. Cell migration assay was applied to investigate the cell migration ability...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29194827/downregulation-of-lncrna-casc2-facilitates-osteosarcoma-growth-and-invasion-through-mir-181a
#13
Zhiwen Ba, Lili Gu, Songnan Hao, Xiaofang Wang, Zhenping Cheng, Guangchen Nie
OBJECTIVES: Long non-coding RNA cancer susceptibility candidate 2 (CASC2) is a novel lncRNA and has been indicated as playing tumour suppressor gene in several tumours. However, the role of CASC2 in osteosarcoma is still uncovered. MATERIALS AND METHODS: The CASC2 and miR-181a expressions were measured via qRT-PCR. CCK-8 assay and colony formation assay were performed to determine the cell growth, and transwell assay was performed to assess the cell invasion. RESULTS: We showed that CASC2 expression was downregulated in osteosarcoma samples and cell lines...
November 30, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/29184421/lncrna-expression-and-implication-in-osteosarcoma-a-systematic-review-and-meta-analysis
#14
Ying Wang, Yuelong Huang, Peng Xiang, Wei Tian
Purpose: Osteosarcoma is the most prevalent primary bone tumor in children, adolescents, and older adults, typically presenting with poor survival outcomes. In recent years, ample evidence has shown that many long noncoding RNAs (lncRNAs) have been aberrantly expressed in osteosarcoma, demonstrating their potential to serve as prognostic markers. In this study, we performed a meta-analysis on four lncRNAs (TUG1, UCA1, BCAR4, and HULC) to systematically evaluate their prognostic value in osteosarcoma...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29170124/long-non-coding-rna-lucat1-modulates-methotrexate-resistance-in-osteosarcoma-via-mir-200c-abcb1-axis
#15
Zhe Han, Liying Shi
Long non-coding RNAs (lncRNAs) have been verified to participate in the tumorigenesis of multiple cancers. Nevertheless, the deepgoing role molecular mechanisms of lncRNAs on osteosarcoma chemoresistance remain unclear. In present study, we investigate the function of lncRNA LUCAT1 on osteosarcoma methotrexate (MTX) resistant phenotype and discover the potential regulatory mechanism. Results showed that LUCAT1 was up-regulated in MTX-resistant cells (MG63/MTX, HOS/MTX) compared to that in parental cells. LncRNA LUCAT1 and ABCB1 protein expression levels were both up-regulated when induced by different concentration of methotrexate...
November 20, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29152092/the-long-non-coding-rna-particle-is-associated-with-wwox-and-the-absence-of-fra16d-breakage-in-osteosarcoma-patients
#16
Valerie Bríd O'Leary, Doris Maugg, Jan Smida, Daniel Baumhoer, Michaela Nathrath, Saak Victor Ovsepian, Michael John Atkinson
Breakage of the fragile site FRA16D disrupts the WWOX (WW Domain Containing Oxidoreductase) tumor suppressor gene in osteosarcoma. However, the frequency of breakage is not sufficient to explain the rate of WWOX loss in pathogenesis. The involvement of non-coding RNA transcripts is proposed due to their accumulation at fragile sites, where they are advocated to influence specific chromosomal regions associated with malignancy. The long ncRNA PARTICLE (promoter of MAT2A antisense radiation-induced circulating long non-coding RNA) is transiently elevated in response to irradiation and influences epigenetic silencing modification within WWOX...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136769/lncrna-p21-inhibited-the-proliferation-of-osteosarcoma-cells-via-the-mir-130b-pten-akt-signaling-pathway
#17
Weifeng Han, Junpeng Liu
Osteosarcoma (OS) is the most common type of malignant bone tumor in children and adolescents. However, the molecular mechanism underlying OS development is unclear. Here, we investigated the contribution of lncRNA-p21, a novel long non-coding RNA, on OS cell proliferation. Our results demonstrated that the expression of lncRNA-p21 was repressed in OS tissue. Growth curves and the cell colony formation assay showed that lncRNA-p21 significantly inhibited the proliferation of OS cell lines. In addition, the expression of lncRNA-p21 increased the protein levels of proliferation markers, such as Ki-67 and cyclin D1...
November 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29119050/long-noncoding-rna-nbat1-negatively-modulates-growth-and-metastasis-of-osteosarcoma-cells-through-suppression-of-mir-21
#18
Cheng Yang, Guijiang Wang, Jian Yang, Liguo Wang
Osteosarcoma (OS) is the most common primary bone malignancies. Long noncoding RNAs (lncRNAs) are key regulatory RNAs which takes part in several biological processes. LncRNA neuroblastoma associated transcript 1 (NBAT1) is a newly identified functional lncRNA. NBAT1 functions as a tumor suppressor in some cancers. However, the expression pattern, the biological function and the mechanisms of NBAT1 in OS progress have not been elucidated. In this study, for the first time, we found that NBAT1 expression is downregulated in OS tissues and cell lines and is associated with clinical stage, distant metastasis and poor prognosis...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29115574/long-non-coding-rna-snhg1-regulates-nob1-expression-by-sponging-mir-326-and-promotes-tumorigenesis-in-osteosarcoma
#19
Jiandong Wang, Lei Cao, Jianhong Wu, Qiugen Wang
The long non-coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) has been demonstrated to participate in the deterioration of many types of cancer. However, the underlying mechanisms of SNHG1-mediating functions in osteosarcoma (OS) have yet to be elucidated. In the present study, our results showed that SNHG1 was upregulated in OS tissues and cell lines, and high SNHG1 expression predicts poor overall survival of OS patients. Knockdown of SNHG1 inhibited cell growth and metastasis of OS in vitro and in vivo...
November 3, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29113674/lncrna-zeb1-as1-predicts-unfavorable-prognosis-in-gastric-cancer
#20
Yanliang Li, Xiaowen Wen, Longgang Wang, Xianjun Sun, Heng Ma, Zheng Fu, Leping Li
OBJECTIVES: LncRNA ZEB1 Antisense 1 (ZEB1-AS1) has been suggested to be an oncogenic role in human hepatocellular carcinoma, osteosarcoma, glioma and esophageal carcinoma progression. However, the clinical significance and biological function of ZEB1-AS1 in gastric cancer is poorly understood. METHODS: Levels of ZEB1-AS1 expression in gastric cancer tissues and cell lines were detected by qRT-PCR. Loss-of-function and gain-of-function studies were conducted to explore the biological function of ZEB1-AS1 in gastric cancer cells migration, invasion and EMT process...
December 2017: Surgical Oncology
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