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lncRNA and Osteosarcoma

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https://www.readbyqxmd.com/read/28519068/long-noncoding-rna-gas5-suppresses-cell-growth-and-epithelial-mesenchymal-transition-in-osteosarcoma-by-regulating-the-mir-221-arhi-pathway
#1
Kaishan Ye, Shuanke Wang, Haihong Zhang, Hua Han, Bing Ma, Wei Nan
Dysregulated long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) play key roles in the development of human cancers. The lncRNA growth arrest-specific 5 (GAS5) is reported to be a tumor suppressor in multiple cancers. However, the roles of GAS5 and its related miRNAs in osteosarcoma are poorly understood. This study explored the potential functions and mechanisms of GAS5 in the tumorigenesis of osteosarcoma. Here, the expression of GAS5, miR-221 and aplasia Ras homologue member I (ARHI) was determined in osteosarcoma tissues and cells by Real-time PCR (RT-qPCR)...
May 18, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28469961/long-non-coding-rna-ak093407-promotes-proliferation-and-inhibits-apoptosis-of-human-osteosarcoma-cells-via-stat3-activation
#2
Yongkun Wang, Tingting Liang, Yao Wang, Yan Huang, Ye Li
Osteosarcoma is a malignant tumor of the skeletal system. Long non-coding RNAs (lncRNAs) have been shown to play significant role in osteosarcoma. The present study evaluated the effects and mechanism of lncRNA AK093407 in osteosarcoma. The study included human osteosarcoma cell line, U-2OS. Cell proliferation, viability, and apoptosis were measured using Ki-67 proliferation assay, MTT assay, and Annexin V/PI staining assay, respectively. Relative mRNA and protein expressions were measured using qRT-PCR and western blot, respectively...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28469952/long-noncoding-rna-atb-promotes-osteosarcoma-cell-proliferation-migration-and-invasion-by-suppressing-mir-200s
#3
Feng Han, Changhe Wang, Yi Wang, Liang Zhang
Long noncoding RNA activated by transforming growth factor-β (lncRNA-ATB) is a novel lncRNA, which is recently reported to have critical roles in carcinogenesis and progression of several cancers. However, the expression, clinical values, biological roles, and underlying molecular mechanisms of lncRNA-ATB in osteosarcoma are still known. In this study, we measured lncRNA-ATB expression in serum and osteosarcoma tissues of osteosarcoma patients, analyzed its diagnostic and prognostic values. Serum lncRNA-ATB is increased in osteosarcoma patients and could accurately discriminate osteosarcoma patients from healthy controls...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28466821/long-non-codingrna-lncrna-tug1-and-the-prognosis-of-cancer-a-meta-analysis
#4
X-H Yu, W Guo, J Zhang, C Ma, A-J Chu, B-L Wen, X Zhang, X-Y Yan, C-M Wu, D-M Wang, Y-L Qu
Some studies assessed the association between lncRNA taurine-upregulated gene 1 (TUG1) and the survival in cancer. However, the results were inconclusive.  Therefore, we performed a meta-analysis to determine this association. We used the following electronic databases to search for eligible literature: PubMed, Embase, Chinese National Knowledge Infrastructure (CNKI) and Wanfang. We used ORs and 95% CIs to measure the association between TUG1 and the survival of cancer. There was no significant association between TUG1 and OS of cancer (HR=1...
March 31, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28415638/altered-long-non-coding-rnas-predict-worse-outcome-in-osteosarcoma-patients-evidence-from-a-meta-analysis
#5
Yanliang Yang, Shunli Wang, Teng Li
Long non-coding RNAs (lncRNAs) are emerging as promising prognostic biomarkers in an expanding list of malignant neoplasms. Here, we sought to investigate the strength of associations between lncRNA signatures and clinical outcomes in osteosarcoma. We conducted a systematic search of the online databases from inception to July 2016. Hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) for the primary endpoints of overall survival (OS), progression-free survival (PFS) or event-free survival (EFS) were extracted and meta-analyzed...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415557/long-non-coding-rna-cta-sensitizes-osteosarcoma-cells-to-doxorubicin-through-inhibition-of-autophagy
#6
Zhengguang Wang, Zhendong Liu, Song Wu
Recently, several long non-coding RNAs (lncRNAs) have been implicated in osteosarcoma (OS). However, the regulatory roles of lncRNAs in chemotherapy resistance of OS still remain unclear. This study aimed to screen a novel lncRNA that contributes to chemotherapeutic resistance of OS, and to explore the underlying mechanisms. Our data showed that lncRNA CTA was markedly downregulated in OS tissues compared to their matched non-tumor tissues, and low expression of lncRNA CTA was significantly associated with the advanced clinical stage and tumor size...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28411362/knockdown-of-long-noncoding-rna-tug1-inhibits-the-proliferation-and-cellular-invasion-of-osteosarcoma-cells-by-sponging-mir-153
#7
Heping Wang, Yanzhang Yu, Shuxin Fan, Leifeng Luo
Long noncoding RNA (lncRNA) Taurine-upregulated gene 1 (TUG1) has been confirmed to be involved in the progression of various cancers, however, its mechanism of action in osteosarcoma has not been well addressed. In our study, TUG1 was overexpressed and miR-153 was downregulated in osteosarcoma tissues and cell lines. Loss-of-function assay showed that TUG1 knockdown suppressed the viability, colony formation, and invasion of osteosarcoma cells in vitro. Moreover, TUG1 was confirmed to be a miR-153 sponge. Ectopic expression of TUG1 reversed the inhibitory effect of miR-153 on the proliferation and invasion of osteosarcoma cells...
April 12, 2017: Oncology Research
https://www.readbyqxmd.com/read/28409547/long-non-coding-rna-xist-promotes-osteosarcoma-progression-by-targeting-ras-related-protein-rap2b-via-mir-320b
#8
Gong-Yi Lv, Jun Miao, Xiao-Lin Zhang
Abnormal expression of long non-coding RNA (lncRNAs) often contributes to unrestricted growth and invasion of cancer cells. LncRNA X-inactive specific transcript (XIST) expression is up-regulated in several cancers, however, its underlying mechanism in osteosarcoma (OS) has not been elucidated. In the present study, we found that XIST expression was significantly increased in osteosarcoma tissues and cell lines by LncRNA Profiler and qRT-PCR. The effects of XIST and miR-320b on osteosarcoma cell proliferation and invasion were studied by MTT assay and Transwell invasion assay...
April 12, 2017: Oncology Research
https://www.readbyqxmd.com/read/28390115/long-noncoding-rna-linc01133-sponges-mir-422a-to-aggravate-the-tumorigenesis-of-human-osteosarcoma
#9
Hai-Feng Zeng, Hai-Yan Qiu, Fa-Bo Feng
Long noncoding RNAs (lncRNAs) have been verified to participate in various types of malignant tumor including osteosarcoma (OS), which is the most common primary bone tumor with outstanding morbidity. Although increasing lncRNAs have been reported to mediate occurrence of OS, the potential mechanisms are still unclear. This study intends to uncover the mechanism by which lncRNA LINC01133 functions as miRNAs sponge to mediate OS tumorigenicity. In this study, we found that the expression level of LINC01133 was statistically up-regulated in OS tumor tissue and cell lines compared to noncancerous tissue and normal human osteoplastic cell line...
March 28, 2017: Oncology Research
https://www.readbyqxmd.com/read/28388584/malat1-predicts-poor-survival-in-osteosarcoma-patients-and-promotes-cell-metastasis-through-associating-with-ezh2
#10
Yanqing Huo, Qingbo Li, Xiqian Wang, Xiejia Jiao, Jiachun Zheng, Zhiqiang Li, Xiaohan Pan
Osteosarcoma is the most common type of bone cancer, especially in children and young adults. Recently, long noncoding RNAs (lncRNAs) have emerged as new prognostic markers and gene regulators in several cancers, including osteosarcoma. In this study, we investigated the contributions of the lncRNA MALAT1 in osteosarcoma with a specific focus on its transcriptional regulation and its interaction with EZH2. Our results showed that MALAT1 was significantly increased in osteosarcoma specimens and cell lines. ROC curve analysis showed that MALAT1 had a higher area under the curve than alkaline phosphatase, and Kaplan-Meier survival analysis indicated that patients with high serum levels of MALAT1 showed reduced survival rate...
March 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28323030/antisense-lncrna-foxc2-as1-promotes-doxorubicin-resistance-in-osteosarcoma-by-increasing-the-expression-of-foxc2
#11
Chun-Lin Zhang, Kun-Peng Zhu, Xiao-Long Ma
Recent efforts have revealed that numerous natural antisense lncRNAs play a crucial role in the regulation of cancer biology. Here, based on our previous study, we further identified that the lncRNA FOXC2-AS1 and its antisense transcript FOXC2 are positively up-regulated in doxorubicin-resistant osteosarcoma cell lines and tissues, correlate with poor prognosis and promote doxorubicin resistance in osteosarcoma cells in vitro and in vivo. In addition, FOXC2-AS1 and FOXC2 are mainly located in the cytoplasm and form an RNA-RNA double-stranded structure in the overlapping region, which is necessary for FOXC2-AS1 to regulate the expression of FOXC2 at both the transcription and post-transcription levels...
June 28, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28123573/transcription-factor-oct4-promotes-osteosarcoma-by-regulating-lncrna-ak055347
#12
Hongwu Fan, Guangyao Liu, Changfu Zhao, Xuefeng Li, Xiaoyu Yang
Osteosarcoma is the most common primary bone tumor in children and adolescents, typically presenting with a poor prognosis. Octamer-binding transcription factor 4 (Oct4) protein, encoded by the POU class 5 homeobox 1 gene, is important in maintaining self-renewal of pluripotent stem cells, and is closely associated with cancer. However, its role in osteosarcoma remains to be elucidated. The present study observed Oct4 was markedly increased in osteosarcoma cell lines and in human osteosarcoma tissue samples...
January 2017: Oncology Letters
https://www.readbyqxmd.com/read/28077810/increased-expression-of-long-non-coding-rna-bcar4-is-predictive-of-poor-prognosis-in-patients-with-non-small-cell-lung-cancer
#13
Jianhua Gong, Han Zhang, Li He, Lixin Wang, Jipeng Wang
Lung cancer is the most common human cancer, and the majority of lung cancer cases are categorized as non-small cell lung cancer (NSCLC). Long non-coding RNAs (lncRNAs) play key roles in the development and progression of human cancers. LncRNA breast cancer anti-estrogen resistance 4 (BCAR4) has been identified as an oncogenic lncRNA involved in the progression of breast cancer and osteosarcoma. However, the clinical significance of the lncRNA BCAR4 in NSCLC remains largely unclear. In the present study, real-time quantitative reverse transcriptase-polymerase chain reaction was used to examine the relative level of lncRNA BCAR4 in 68 cases of NSCLC tissues and their adjacent non-tumor tissues...
January 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28009431/up-regulation-of-long-noncoding-rna-ccal-predicts-poor-patient-prognosis-and-promotes-tumor-metastasis-in-osteosarcoma
#14
Da-Kai Zhou, Xi-Wang Yang, Huining Li, Yongbo Yang, Zhen-Jun Zhu, Na Wu
BACKGROUND: Long noncoding RNAs (lncRNAs) play essential roles in tumor progression. Aberrant colorectal cancer-associated lncRNA (CCAL) has been found in colorectal cancer. However, the function of lncRNA CCAL in osteosarcoma (OS) remains unclear. METHODS: Quantitative real-time PCR (qRT-PCR) was performed to measure CCAL expression in OS tissues and adjacent nontumor tissues. The correlation betweent CCAL expression and clinicopathological features and prognosis was also analyzed...
March 2, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/27860482/long-noncoding-rna-ewsat1-promotes-osteosarcoma-cell-growth-and-metastasis-through-suppression-of-meg3-expression
#15
Lishan Sun, Cheng Yang, Juan Xu, Yanhong Feng, Liguo Wang, Tao Cui
Osteosarcoma (OS) is the most common primary bone tumor in children and adolescents. Long noncoding RNAs (lncRNAs) are a class of transcriptional products of the genome without protein-coding potential. Recently, lncRNA Ewing sarcoma-associated transcript 1 (EWSAT1) was functionally identified in Ewing sarcoma, a highly aggressive primary pediatric bone tumor. However, whether EWSAT1 plays a role in OS remains unclear. In the present study, gain- and loss-of-function assays demonstrated that EWSAT1 enhanced OS cell proliferation, migration, and invasion...
December 2016: DNA and Cell Biology
https://www.readbyqxmd.com/read/27829995/long-noncoding-rna-zeb1-as1-acts-as-an-oncogene-in-osteosarcoma-by-epigenetically-activating-zeb1
#16
Chibo Liu, Jianjun Lin
Long noncoding RNAs (lncRNAs) have been demonstrated to be dysregulated in many disease states and have pivotal roles in various pathophysiological processes. However, the expression, roles and potential mechanism of lncRNA ZEB1-AS1 in osteosarcoma are still unknown. In this study, we measured ZEB1-AS1 expression and the results showed that ZEB1-AS1 was upregulated in osteosarcoma tissues and cells. Increased expression of ZEB1-AS1 is correlated with larger tumor size, progressed Enneking stage, tumor metastasis, worse recurrence-free and overall survival of osteosarcoma patients...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27813492/long-non-coding-rna-pvt1-promotes-osteosarcoma-development-by-acting-as-a-molecular-sponge-to-regulate-mir-195
#17
Quan Zhou, Fengli Chen, Jiali Zhao, Baojun Li, Yong Liang, Wei Pan, Shaoxian Zhang, Xinhong Wang, Donghui Zheng
A growing body of evidence has indicated that long non-coding RNAs (lncRNAs) serve as competing endogenous RNAs (ceRNAs) during oncogenesis. In this study, the qRT-PCR results indicated that the lncRNA PVT1 is overexpressed in osteosarcoma and decreased the survival rate of osteosarcoma patients. MTT and clonal colony formation assays were used to detect the effect of PVT1 on proliferation, and flow cytometry was performed to assess apoptosis and the cell cycle. A Transwell assay was used to analyze migration and invasion...
December 13, 2016: Oncotarget
https://www.readbyqxmd.com/read/27706792/retraction-of-articles-with-plagiarism-in-common-with-other-publications
#18
(no author information available yet)
The GMR editorial staff was alerted about some manuscripts that were found to be substantially equal. The Publisher and Editor decided to retract these articles in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation, we have strong reason to believe that the peer review process was failure and, after review and contacting the authors, the editors of Genetics and Molecular Research decided to retract these articles. The authors and their institutions were advised of this serious breach of ethics...
September 30, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27660759/role-of-long-noncoding-rna-hotair-in-the-growth-and-apoptosis-of-osteosarcoma-cell-mg-63
#19
Hua Zheng, Jing Min
This study investigated the function of HOTAIR in the growth and apoptosis of OS MG-63 cell line in vitro and further clarified its mechanism. The expression levels of HOTAIR in OS MG-63 cell line and normal osteoblast hFOB1.19 cell line were determined by RT-PCR, respectively. The growth and apoptosis of MG-63 cells in vitro were investigated by MTT assay and flow cytometry assay after HOTAIR was knocked down with retroviral vector construction. And the expression levels of cell growth and apoptosis related factors TGF-β, p53, Bcl-2, and TNF-α were determined to clarify the mechanism...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27658774/long-non-coding-rna-tug1-contributes-to-tumorigenesis-of-human-osteosarcoma-by-sponging-mir-9-5p-and-regulating-pou2f1-expression
#20
Chu-Hai Xie, Yan-Ming Cao, Yan Huang, Qun-Wei Shi, Jian-Hong Guo, Zi-Wen Fan, Ju-Gen Li, Bin-Wei Chen, Bo-Yi Wu
Recent studies have shown that long non-coding RNAs (lncRNAs) have critical roles in tumorigenesis, including osteosarcoma. The lncRNA taurine-upregulated gene 1 (TUG1) was reported to be involved in the progression of osteosarcoma. Here, we investigated the role of TUG1 in osteosarcoma cells and the underlying mechanism. TUG1 expression was measured in osteosarcoma cell lines and human normal osteoblast cells by quantitative real-time PCR (qRT-PCR). The effects of TUG1 on osteosarcoma cells were studied by RNA interference in vitro and in vivo...
November 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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