Wenwen Guo, Xiaoyu Lin, Ran Zhang, Lei Hu, Jiangyi Wang, Fu Wang, Jinsong Wang, Chunmei Zhang, Xiaoshan Wu, Songlin Wang
The fibroblast growth factor (FGF) pathway plays an important role in epithelial-mesenchymal interactions during tooth development. Nevertheless, how the ligands, receptors, and antagonists of the FGF pathway are involved in epithelial-mesenchymal interactions remains largely unknown. Miniature pigs exhibit tooth anatomy and replacement patterns like those in humans and hence can serve as large animal models. The present study investigated the spatiotemporal expression patterns of critical genes encoding FGF ligands ( FGF3 , FGF4 , FGF7 , and FGF9 ), antagonists ( SPRY2 and SPRY4 ) and receptors ( FGFR1 , FGFR2 , and FGFR3 ) in the third deciduous molars of miniature pigs at the cap (embryonic day 40, E40), early bell (E50), and late bell (E60) stages...
2022: International Journal of Medical Sciences