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https://www.readbyqxmd.com/read/28295819/variants-in-bak1-spry4-and-gab2-are-associated-with-pediatric-germ-cell-tumors-a-report-from-the-children-s-oncology-group
#1
Erin L Marcotte, Nathan Pankratz, James F Amatruda, A Lindsay Frazier, Mark Krailo, Stella Davies, Jacqueline R Starr, C Lau Ching, Michelle Roesler, Erica Langer, Caroline Hallstrom, Anthony J Hooten, Jenny N Poynter
Germ cell tumors (GCT) are a rare form of childhood cancer that originate from the primordial germ cell. Recent genome-wide association studies (GWAS) have identified susceptibility alleles for adult testicular GCT (TGCT). We test whether these SNPs are associated with GCT in pediatric and adolescent populations. This case-parent triad study includes individuals with GCT diagnosed between ages 0-19. We evaluated 26 SNPs from GWAS of adult TGCT and estimated main effects for pediatric GCT within complete trios (N=366) using the transmission disequilibrium test...
March 13, 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/28275056/ksrp-promotes-post-transcriptional-destabilization-of-spry4-transcripts-in-non-small-cell-lung-cancer
#2
Rama Kamesh Bikkavilli, Sereke Adam Zerayesus, Michelle Van Scoyk, Lora Wilson, Pei-Ying Wu, Abhinaya Baskaran, Ke Tang, Syed Raheem, Blain A Samuelson, Narsa M Reddy, Sekhar P Reddy, Carlyne D Cool, Beata Kosmider, Sreedevi Avasarala, Robert A Winn
AU-rich element binding proteins (ARE-BPs) offer post-transcriptional regulation of gene expression via physical interaction and recruitment of RNA decay machinery to the AU-rich elements within the 3'UTR of the target transcripts. However, the role of ARE-BPs in lung cancer remains poorly understood. In this study, we have identified that K-homology splicing regulatory protein (KSRP), an ARE-BP, is robustly up-regulated in human lung cancer. Importantly, Kaplan-Meier survival analysis indicated that elevated KSRP expression was correlated with poor overall survival of lung cancer patients...
March 8, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28247935/prognostic-significance-of-long-noncoding-rna-z38-as-a-candidate-biomarker-in-breast-cancer
#3
Zhen-Lin Nie, Yi-Shan Wang, Yan-Ping Mei, Xin Lin, Guo-Xing Zhang, Hui-Ling Sun, Yi-Lian Wang, Yong-Xiang Xia, Shu-Kui Wang
BACKGROUND: Long noncoding RNA (lncRNA) Z38 has been shown to promote cell proliferation and tumorigenesis in breast cancer. However, expression pattern and prognostic value of lncRNA Z38 in breast cancer patients remain elusive. METHODS: The expression levels of SPRY4-IT1 in 110 self-paired specimens of breast cancer and adjacent normal breast tissues were measured by quantitative real-time PCR (qRT-PCR), and its correlation with overall survival of patients with breast cancer was further statistically analyzed...
March 1, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28129625/upregulation-of-the-long-non-coding-rna-spry4-it1-indicates-a-poor-prognosis-and-promotes-tumorigenesis-in-ovarian-cancer
#4
Hongxia Li, Chunhua Liu, Zhanbin Lu, Li Chen, Juan Wang, Yindi Li, Huiping Ma
Long non-coding RNAs (lncRNAs) have been identified to be critical mediators in various tumors associated with cancer progression. LncRNA SPRY4-IT1 serves as a novel prognostic biomarker for hepatocellular carcinoma. However, the biological role and clinical significance of lncRNA SPRY4-IT1 in human ovarian cancer (OC) need to be completely elucidated. The aim of the present study was to explore the lncRNA SPRY4-IT1 expression in human OC patients and its role in OC cells. We show that lncRNA SPRY4-IT1 expression is significantly upregulated in ovarian tumor tissues and OC cell lines in comparison with adjacent non-tumor control tissues and the human ovarian immortalized nontumorigenic ovarian surface epithelial (IOSE), respectively...
April 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28099409/up-regulated-expression-of-spry4-it1-predicts-poor-prognosis-in-colorectal-cancer
#5
Wenlong Tan, Zi-Zheng Song, Qunfang Xu, Xinyan Qu, Zhen Li, Yu Wang, Qun Yu, Shengqi Wang
BACKGROUND Long non-coding RNA SPRY4 intronic transcript 1 (lncRNA SPRY4-IT1) has been reported to be associated with the progression of several cancers, but its expression level in colorectal cancer (CRC) has rarely been reported. The purpose of this study was to estimate the clinical significance of SPRY4-IT1 in CRC. MATERIAL AND METHODS The relative expression levels of SPRY4-IT1 were detected by quantitative real-time polymerase chain reaction (qRT-PCR) in diseased tissues and the adjacent normal tissues of 106 CRC patients...
January 18, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28064312/-polymorphisms-of-kitlg-spry4-and-bak1-genes-in-patients-with-testicular-germ-cell-tumors-and-individuals-with-infertility-associated-with-azfc-deletion-of-the-y-chromosome
#6
M V Nemtsova, E V Ivkin, O A Simonova, V V Rudenko, V B Chernykh, D S Mikhaylenko, O B Loran
Testicular cancer is the most common form of solid cancer in young men. Testicular cancer is represented by testicular germ cell tumors (TGCTs) derived from embryonic stem cells with different degrees of differentiation in about 95% of cases. The development of these tumors is related to the formation of a pool of male germ cells and gametogenesis. Clinical factors that are predisposed to the development of germ-cell tumors include cryptorchidism and testicular microlithiasis, as well as infertility associated with the gr/gr deletion within the AZFс locus...
November 2016: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/28054316/long-non-coding-rna-spry4-it1-can-predict-unfavorable-prognosis-and-lymph-node-metastasis-a-meta-analysis
#7
Nandi Li, Qian Tan, Wei Jing, Ping Luo, Jiancheng Tu
Emerging evidences suggested that long non-coding RNAs (lncRNAs) play an interesting role in the tumor development and progression in various types of cancer. The aim of this study was to analyse the potential prognostic value for cancer patients . We systematically searched the reports through PubMed, Web of Science, Medline, CNKI, and the Cochrane Library from inception to March, 2016, and carefully identified according to eligibility criteria. This quantitative meta-analysis collected all relevant articles to investigated the association of SPRY4-IT1 expression status with overall survival (OS) and lymph node metastasis (LNM)...
January 4, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27998761/lncrna-spry4-it1-sponges-mir-101-3p-to-promote-proliferation-and-metastasis-of-bladder-cancer-cells-through-up-regulating-ezh2
#8
Dong Liu, Yawei Li, Gang Luo, Xingyuan Xiao, Dan Tao, Xinchao Wu, Miao Wang, Chao Huang, Liang Wang, Fuqing Zeng, Guosong Jiang
Emerging evidences have indicated that long non-coding RNAs (LncRNAs) play vital roles in cancer development and progression. Previous studies have suggested that overexpression of SPRY4-IT1 predicates poor prognosis and promotes tumor progress in several cancers. However, the underlying mechanism of SPRY4-IT1 in bladder cancer remains unknown. In this study, we found that SPRY4-IT1 knockdown induced inhibition of cell proliferation, cell migration and invasion ability, and caused promotion of apoptosis in bladder cancer both in vitro and in vivo...
March 1, 2017: Cancer Letters
https://www.readbyqxmd.com/read/27997895/lower-expression-of-spry4-predicts-a-poor-prognosis-and-regulates-cell-proliferation-in-colorectal-cancer
#9
Xiaoling Zhou, Sheng Xie, Chunluan Yuan, Li Jiang, Xiaoyan Huang, Liumei Li, Yan Chen, Lichuan Luo, Jianxuan Zhang, Daogang Wang, Lijian Liu, Wei Shi, Liang Han, Nong Tang, Yunxi Ji
BACKGROUND/AIMS: Colorectal cancer (CRC) is the third most common type of cancer worldwide. Sprouty proteins are modulators of mitogeninduced signal transduction processes and therefore can influence the process of cancerogenesis. The encoded protein of Sprouty homolog 4 (SPRY4) is associated with various human cancers. However, its biological role and clinical significance in CRC development and progression are unknown. METHODS: The aim of this study was to evaluate the expression and biological role of SPRY4 in colorectal cancer...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27956498/h3k27-acetylation-activated-long-non-coding-rna-ccat1-affects-cell-proliferation-and-migration-by-regulating-spry4-and-hoxb13-expression-in-esophageal-squamous-cell-carcinoma
#10
Erbao Zhang, Liang Han, Dandan Yin, Xuezhi He, Linzhi Hong, Xinxin Si, Mantang Qiu, Tongpeng Xu, Wei De, Lin Xu, Yongqian Shu, Jinfei Chen
Recently, long non-coding RNAs (lncRNAs) have been shown to have important regulatory roles in human cancer biology. In our study, we found that lncRNA CCAT1, whose expression is significantly increased and is correlated with outcomes in Esophageal Squamous Cell Carcinoma (ESCC). Consecutive experiments confirmed that H3K27-acetylation could activate expression of colon cancer associated transcript-1 (CCAT1). Further experiments revealed that CCAT1 knockdown significantly repressed the proliferation and migration both in vitro and in vivo RNA-seq analysis revealed that CCAT1 knockdown preferentially affected genes that are linked to cell proliferation, cell migration and cell adhesion...
December 11, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27902971/long-non-coding-rna-spry4-it1-promotes-gallbladder-carcinoma-progression
#11
Liang Yang, Xi Cheng, Naijian Ge, Weixing Guo, Feiling Feng, Fuying Wan
Gallbladder carcinoma (GBC) is the most common malignancy of the bile duct and patients with GBC have extremely poor prognoses. Long non-coding RNAs (lncRNAs) are found to be dysregulated in a variety of cancers, including GBC. SPRY4-IT1 has been recently revealed as oncogenic regulator in many cancers. However, whether SPRY4-IT1 is involved in GBC progression remains largely unknown. To investigate the role of SPRY4-IT1 in GBC, we evaluated the expression SPRY4-IT1 in GBC tissues and cell lines, and investigated the effect of SPRY4-IT1 knockdown on cell proliferation, migration and invasion of GBC in vitro...
January 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/27899259/overexpression-of-the-long-non-coding-rna-spry4-it1-promotes-tumor-cell-proliferation-and-invasion-by-activating-ezh2-in-hepatocellular-carcinoma
#12
Meng Zhou, Xiao-Yu Zhang, Xi Yu
BACKGROUND: Increasing evidences have demonstrated that the dysregulation of long non-coding RNAs (lncRNAs) may act as an important role in tumor progression. The long non-coding RNA SPRY4 intronic transcript 1 (SPRY4-IT1) has been reported in some cancer including regulating cell growth, differentiation, apoptosis, and cancer progression. However, the expression and function of SPRY4-IT1 in the progression of hepatocellular carcinoma (HCC) remain largely unknown. METHODS: The lncRNA SPRY4-IT1 was detected by quantitative real time PCR (qRT-PCR) in HCC cell lines, CCK8 cell proliferation and transwell invasion assays were performed to detect the GC cell proliferation and invasion abilities...
January 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27853262/the-lnc-rna-spry4-it1-modulates-trophoblast-cell-invasion-and-migration-by-affecting-the-epithelial-mesenchymal-transition
#13
Qing Zuo, Shiyun Huang, Yanfen Zou, Yetao Xu, Ziyan Jiang, Shan Zou, Haoqing Xu, Lizhou Sun
Preeclampsia is a common, pregnancy-specific disease and a major contributor to maternal and foetal morbidity and mortality. Some placental abnormalities, including deficient implantation, abnormal trophoblast cell function, and improper placental vascular development, are believed to lead to preeclampsia. The long noncoding RNA SPRY4-IT1 is more highly expressed in preeclamptic human placentas than in normal placentas. We assessed the role of epithelial-mesenchymal transition (EMT)-associated invasion and migration in HTR-8/SVneo trophoblast cells...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27704722/posttranscriptional-regulation-of-intestinal-epithelial-integrity-by-noncoding-rnas
#14
REVIEW
Jun-Yao Wang, Lan Xiao, Jian-Ying Wang
Maintenance of the gut epithelial integrity under stressful environments requires epithelial cells to rapidly elicit changes in gene expression patterns to regulate their survival, adapt to stress, and keep epithelial homeostasis. Disruption of the intestinal epithelial integrity occurs commonly in patients with various critical illnesses, leading to the translocation of luminal toxic substances and bacteria to the blood stream. Recently, noncoding RNAs (ncRNAs) have emerged as a novel class of master regulators of gene expression and are fundamentally involved in many aspects of gut mucosal regeneration, protection, and epithelial barrier function...
March 2017: Wiley Interdisciplinary Reviews. RNA
https://www.readbyqxmd.com/read/27660833/novel-function-of-sprouty4-as-a-regulator-of-stemness-and-differentiation-of-embryonic-stem-cells
#15
Jae-Young Lee, Sunghyun Park, Kwang-Soo Kim, Jeong-Jae Ko, Soohong Lee, Keun Pil Kim, Kyung-Soon Park
Sprouty (Spry) genes encode inhibitors of the receptor tyrosine kinase signaling cascade, which plays important roles in stem cells. However, the role of Spry4 in the stemness of embryonic stem cells has not been fully elucidated. Here, we used mouse embryonic stem cells (mESCs) as a model system to investigate the role of Spry4 in the stem cells. Suppression of Spry4 expression results in the decreases of cell proliferation, EB formation and stemness marker expression, suggesting that Spry4 activity is associated with stemness of mESCs...
June 2016: Balsaeng'gwa Saengsig
https://www.readbyqxmd.com/read/27642559/upregulation-of-long-noncoding-rna-spry4-it1-correlates-with-tumor-progression-and-poor-prognosis-in-cervical-cancer
#16
Yang Cao, Yinglei Liu, Xiaoyan Lu, Ying Wang, Haifeng Qiao, Manhua Liu
The identification of cancer-associated long noncoding RNA (lncRNA) is critical for us to understand cancer pathogenesis and development. The aim of this study was to evaluate the expression profile of the lncRNA SPRY4-IT1 in cervical cancer and to identify its clinical significance in cancer progression. The expression levels of SPRY4-IT1 in cervical cancer tissues were measured by quantitative real-time PCR, and its correlation with overall survival of cervical cancer patients was analyzed statistically. Our results showed that the expression levels of SPRY4-IT1 were higher in cervical cancer tissues than in adjacent normal tissues...
September 2016: FEBS Open Bio
https://www.readbyqxmd.com/read/27621655/long-noncoding-rna-spry4-it1-promotes-malignant-development-of-colorectal-cancer-by-targeting-epithelial-mesenchymal-transition
#17
Dong Cao, Qiong Ding, Wubin Yu, Ming Gao, Yilian Wang
The clinical significance and biological functions of long noncoding RNA SPRY4 intronic transcript 1 (SPRY4-IT1) in colorectal cancer (CRC) remain largely unclear. Herein, we are the first to report that the SPRY4-IT1 was significantly upregulated in CRC tissues, serum, and cells. Higher SPRY4-IT1 expression was markedly associated with advanced Tumor Node Metastasis (TNM) stage in a cohort of 84 CRC patients. Multivariate analyses indicated that SPRY4-IT1 expression could be useful as an independent predictor for overall survival...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27561106/gene-expression-changes-underlying-idiopathic-central-hypogonadism-in-cryptorchidism-with-defective-mini-puberty
#18
Faruk Hadziselimovic, Katharina Gegenschatz-Schmid, Gilvydas Verkauskas, Maria J Docampo-Garcia, Philippe Demougin, Vytautas Bilius, Dalius Malcius, Darius Dasevicius, Michael B Stadtler
The whole genome RNA profiling of testicular biopsies by DNA strand-specific RNA sequencing was examined to determine a potential causative role of isolated congenital cryptorchidism in azoospermia and/or infertility in the context of our previously published GeneChip data. Cryptorchid patients, aged 7 months to 5 years and otherwise healthy, were enrolled in this prospective study. During surgery, testicular tissue biopsies were obtained for histological examination and RNA sequencing. Fifteen patients were selected based on the histological results and were divided into 2 groups...
2016: Sexual Development: Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
https://www.readbyqxmd.com/read/27460732/long-noncoding-rna-spry4-it1-is-a-prognostic-factor-for-poor-overall-survival-and-has-an-oncogenic-role-in-glioma
#19
Y Zhou, D-L Wang, Q Pang
OBJECTIVE: Long non-coding RNAs (lncRNAs) are emerging as biomarkers and as important regulators of the biological processes and tumorigenesis in cancer. The purpose of this study is to investigate the clinical significance of lncRNA SPRY4-IT1 in glioma. PATIENTS AND METHODS: The expression level of SPRY4-IT1 was examined by the quantitative Real-time PCR (qRT-PCR) in glioma tissues and control tissues and its association with overall survival of patients was analyzed by statistical analysis...
July 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27453415/upregulated-long-noncoding-rna-spry4-it1-contributes-to-increased-cell-viability-by-activating-zinc-finger-703-expression-in-esophageal-squamous-cell-carcinoma
#20
J Xue-Liang, W Ming-Dong, Z Ya-Bi, W Wang-Yue
OBJECTIVES: The function of long noncoding RNA SPRY4-IT1 in human esophageal squamous cell carcinoma (ESCC) has been showed in the former studies. The purpose of this study was to further analyze the underlined mechanisms responsible for its role in ESCC cells. MATERIALS AND METHODS: Quantitative reverse transcriptase polymerase chain reaction was firstly used to measure the expression of SPRY4-IT1 in 50 ESCC patients of different clinical stages. Loss of function approach was then applied to confirm the biological function, especially cell viabilities in cultured ESCC cells, by cell counting kit-8 and clonogenic assay...
December 2015: Indian Journal of Cancer
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