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https://www.readbyqxmd.com/read/29242380/insights-into-the-proteome-of-gastrointestinal-stromal-tumors-derived-exosomes-reveals-new-potential-diagnostic-biomarkers
#1
Safinur Atay, Daniel W Wilkey, Mohammed M Milhem, Michael Merchant, Andrew K Godwin
Developing tumors continuously release nano-sized vesicles that represent circulating "fingerprints" of the tumor's identity.  In gastrointestinal stromal tumor (GIST), we have previously reported that these tumors release "oncosomes" carrying the constitutively activated tyrosine kinase (TK) receptor KIT.  Despite the clinical utility of TK inhibitors, such as imatinib mesylate (IM), recurrence and metastasis are clinical problems that urge the need to identify new tumor-derived molecules.  To this aim, we performed the first high quality proteomic study of GIST-derived exosomes (GDEs) and identified 1,060 proteins composing the core GDE proteome (cGDEp)...
December 14, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29234152/lncrna-spry4-it-was-concerned-with-the-poor-prognosis-and-contributed-to-the-progression-of-thyroid-cancer
#2
Haoyu Zhou, Zhihua Sun, Songwei Li, Xiaofeng Wang, Xuejun Zhou
Long non-coding RNAs (lncRNAs) have been demonstrated to be critical regulators in tumorigenesis. LncRNA SPRY4-IT1 has been identified as critical regulator for hepatocellular carcinoma and ovarian cancer. However, the potential role and clinical value of SPRY4-IT1 in human thyroid cancer (TC) still remain unclear and need to be uncovered. Our current study was aimed to ascertain the biological role of expression of SPRY4-IT1 in TC tissues and cells. Our findings revealed that the level of SPRY4-IT1 was significantly upregulated in TC tissues and cell lines, which was correlated with poor prognosis...
December 12, 2017: Cancer Gene Therapy
https://www.readbyqxmd.com/read/29214989/long-non-coding-rna-spry4-it1-promotes-development-of-hepatic-cellular-carcinoma-by-interacting-with-err%C3%AE-and-predicts-poor-prognosis
#3
Guifang Yu, Jieheng Lin, Chengcheng Liu, Kailian Hou, Min Liang, Boyun Shi
Hepatocellular carcinoma (HCC) has become one of the most common leading causes of cancer-related deaths worldwide. This study investigates the role of lncRNA, SPRY4-IT1 in the development of HCC. Quantitative real-time PCR (qRT-PCR) was performed and the results showed that SPRY4-IT1 expression was up-regulated in HCC tissues and high expression of SPRY4-IT1 was associated with poor 5-year overall survival in the HCC patient cohort. Clinicopathological analysis showed that the expression of SPRY4-IT1 was significantly correlated with TNM stage in HCC patients...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29168882/fibroblast-growth-factor-2-regulates-activity-and-gene-expression-of-human-postmitotic-excitatory-neurons
#4
Shweta Gupta, Tanya M-Redmond, Fan Meng, Andrew Tidball, Huda Akil, Stanley Watson, Jack M Parent, Michael Uhler
Many neuropsychiatric disorders are thought to result from subtle changes in neural circuit formation. We used human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) to model mature, postmitotic excitatory neurons and examine effects of FGF2. FGF2 gene expression is known to be altered in brain regions of major depressive disorder (MDD) patients and FGF2 has anti-depressive effects in animal models of depression. We generated stable inducible neurons (siNeurons) conditionally expressing human neurogenin 2 (NEUROG2) to generate a homogenous population of post-mitotic excitatory neurons and study the functional as well as the transcriptional effects of FGF2...
November 23, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29145271/tug1-spry4-it1-and-hulc-as-valuable-prognostic-biomarkers-of-survival-in-cancer-a-prisma-compliant-meta-analysis
#5
Yucheng Zhong, Zhicong Chen, Shuyuan Guo, Xinhui Liao, Haibiao Xie, Yien Zheng, Bin Cai, Peixian Huang, Yuhan Liu, Qun Zhou, Yuchen Liu, Weiren Huang
BACKGROUND: Long noncoding RNAs (LncRNAs) are involved in the development and progression of various cancers. Accumulating evidences indicated that expression of lncRNAs was related to the prognosis of tumors. METHODS: Here, 3 well-known lncRNAs associated with cancer were gathered to prove the potential role of lncRNAs as novel predictors of survival in human cancer. This meta-analysis collected all eligible studies about TUG1, SPRY4-IT1, and HULC and explored the relationship between lncRNAs expression and lymph node metastasis (LNM) or overall survival (OS)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29048686/mir-1908-as-a-novel-prognosis-marker-of-glioma-via-promoting-malignant-phenotype-and-modulating-spry4-raf1-axis
#6
Zhi Chai, Huijie Fan, Yanyan Li, Lijuan Song, Xiaoming Jin, Jiezhong Yu, Yanhua Li, Cungen Ma, Ran Zhou
MicroRNAs (miRNAs) are reported to be involved in the development of glioma. However, study on miRNAs in glioma is limited. The present study aimed to identify miRNAs which can act as potential novel prognostic markers for glioma and analyze its possible mechanism. We show that miR-1908 correlates with shorter survival time of glioma patients via promoting cell proliferation, invasion, anti-apoptosis and regulating SPRY4/RAF1 axis. Analysis of GEO and TCGA database found that miR-1908 was significantly upregulated in glioma tissues, and strongly associated with shorter survival time of glioma patients...
September 26, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28965279/long-non-coding-rna-spry4-it1-can-predict-poor-prognosis-in-digestive-system-malignancies-a-meta-analysis
#7
Cheng Sun, Yangyang Ding, Shimin Wang, Wei Hu
Recent studies have reported that long non-coding RNA SPRY4 intron transcript 1 (SPRY4-IT1) is abnormally expressed in malignant digestive tumors and associated with prognosis. But its clinical relevance is unclear. Here, we performed a meta-analysis aims to evaluate the prognostic value of SPRY4-IT1 in digestive system malignancies. We systematic search the PubMed, Web of Science, ScienceDirect and Wiley Online Library database to eligible studies. The pooled hazard ratios (HRs) with a 95% confidence interval (95% CI) were calculated to explored the association of lncRNA SPRY4-IT1 with prognosis...
September 30, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28940816/clinical-impact-of-kmt2c-and-spry4-expression-levels-in-intensively-treated-younger-adult-acute-myeloid-leukemia-patients
#8
Sabine Kayser, Maximilian Feszler, Julia Krzykalla, Matthias Schick, Michael Kramer, Axel Benner, Felicitas Thol, Uwe Platzbecker, Carsten Müller-Tidow, Anthony D Ho, Gerhard Ehninger, Michael Heuser, Richard F Schlenk, Christian Thiede, Christoph Röllig, Alwin Krämer
OBJECTIVE: To evaluate the prognostic impact of gene expression levels (ELs) of two tumor suppressor genes, sprouty 4 (SPRY4, located on 5q) and lysine methyltransferase 2C (KMT2C, located on 7q) in correlation with clinical characteristics and genetic abnormalities assessed at initial diagnosis in acute myeloid leukemia (AML). METHOD: Gene expression levels were measured on cDNA by RT-qPCR from diagnostic bone marrow samples of 275 intensively treated adult AML patients (median age, 48 years)...
September 22, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28881629/up-regulation-of-long-non-coding-rna-spry4-it1-promotes-tumor-cell-migration-and-invasion-in-lung-adenocarcinoma
#9
Xia Zhang, Qingyan Chi, Zhenhua Zhao
Long non-coding RNAs (lncRNAs) play important role in a variety of biological processes, and are tightly associated with tumorigenesis and cancer prognosis. However, the potential power of lncRNA signatures in predicting survival of patients with lung adenocarcinoma (LUAD) has not been investigated. Here, we identified a four-lncRNA signature (SPRY4-IT1, LINC00941,GPR158-AS1 and KCNK15-AS1) displaying prognostic values for LUAD using The Cancer Genome Atlas (TCGA) dataset. Based on the four-lncRNA signature, the LUAD patients can be classified into high-risk and low-risk groups with significantly different survival...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28796375/effects-of-long-noncoding-rna-spry4-it1-mediated-ezh2-on-the-invasion-and-migration-of-lung-adenocarcinoma
#10
Xin Wen, Xin-Rui Han, Yong-Jian Wang, Shao-Hua Fan, Juan Zhuang, Zi-Feng Zhang, Qun Shan, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Qiao Wu, Jun-Hua Tan, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng
We aim to investigate the interaction between the EZH2 and the long noncoding RNA (lncRNA) SPRY4-IT1. We also explore their respective effects on human lung adenocarcinoma (LA) cell invasion and migration. Both LA and adjacent normal tissues were obtained from 256 LA patients. SPTY4-IT expression and EZH2 mRNA expressions in tissues and cells were detected by reverse transcription quantitative polymerase chain reaction (RT-qPCR). The siRNAs against SPRY4-IT1 and EZH2 were co-transfected into A549 and H1975 cells...
August 10, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28732181/irf6-and-spry4-signaling-interact-in-periderm-development
#11
Y A Kousa, R Roushangar, N Patel, A Walter, P Marangoni, R Krumlauf, O D Klein, B C Schutte
Rare mutations in IRF6 and GRHL3 cause Van der Woude syndrome, an autosomal dominant orofacial clefting disorder. Common variants in IRF6 and GRHL3 also contribute risk for isolated orofacial clefting. Similarly, variants within genes that encode receptor tyrosine kinase (RTK) signaling components, including members of the FGF pathway, EPHA3 and SPRY2, also contribute risk for isolated orofacial clefting. In the mouse, loss of Irf6 or perturbation of Fgf signaling leads to abnormal oral epithelial adhesions and cleft palate...
October 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28720069/long-non-coding-rna-spry4-it1-promotes-proliferation-and-invasion-by-acting-as-a-cerna-of-mir-101-3p-in-colorectal-cancer-cells
#12
Jianguang Jin, Zhijie Chu, Pengfei Ma, Yuanpu Meng, Yanhui Yang
Long non-coding RNAs are associated with a spectrum of biological processes such as gene regulation on transcriptional and post-transcriptional levels. Increasing evidence indicates that SPRY4-IT1 plays an important role in carcinogenesis, and the mechanisms whereby SPRY4-IT1 induces colorectal carcinoma progression remain largely unknown. The aim of this study is to evaluate the expression and function of SPRY4-IT1 in colorectal carcinoma. In this study, we analyzed SPRY4-IT1 expression levels in a series of colorectal carcinoma patients by quantitative reverse transcription polymerase chain reaction...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28691641/decreased-long-non-coding-rna-spry4-it1-contributes-to-ovarian-cancer-cell-metastasis-partly-via-affecting-epithelial-mesenchymal-transition
#13
Jing Yu, Qi Han, Yulan Cui
Long non-coding RNAs play important roles in the regulation of cellular processes including cell proliferation, differentiation, and metastasis. The dysregulation of long non-coding RNAs, such as the SPRY4-IT1 (SPRY4 intronic transcript 1), has been associated with various types of malignancies. However, the functional roles and regulatory mechanism of SPRY4-IT1 in ovarian cancer remain to be elucidated. Here, we quantified the expression level of SPRY4-IT1 in ovarian cancer patients and found its downregulation in ovarian cancer tissues compared to the adjacent normal tissues...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28651500/spry4-it1-a-novel-oncogenic-long-non-coding-rna-in-human-cancers
#14
Jianfa Li, Yincong Chen, Zhicong Chen, Anbang He, Haibiao Xie, Qiaoxiao Zhang, Zhiming Cai, Yuchen Liu, Weiren Huang
Long non-coding RNAs are classified as a kind of RNA, which are longer than 200 nucleotides in length and cannot be translated into proteins. Multiple studies have demonstrated that long non-coding RNAs are involved in various cellular processes, including proliferation, differentiation, cell death, and metastasis. Among numerous long non-coding RNAs, we focus on Sprouty4-Intron 1 (SPRY4-IT1), a well-known long non-coding RNA that is overexpressed in various kinds of tumor tissues and cell lines. Accumulating evidences show that SPRY4-IT1 was dysregulated in various cancers, including melanoma, breast cancer, esophageal squamous cell carcinoma, non-small cell lung cancer, gastric cancer, colon cancer, and hepatocellular carcinoma, and amplification of SPRY4-IT1 was associated with different clinicopathological features of cancer patients...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28539120/comprehensive-whole-genome-sequence-analyses-yields-novel-genetic-and-structural-insights-for-intellectual-disability
#15
Farah R Zahir, Jill C Mwenifumbo, Hye-Jung E Chun, Emilia L Lim, Clara D M Van Karnebeek, Madeline Couse, Karen L Mungall, Leora Lee, Nancy Makela, Linlea Armstrong, Cornelius F Boerkoel, Sylvie L Langlois, Barbara M McGillivray, Steven J M Jones, Jan M Friedman, Marco A Marra
BACKGROUND: Intellectual Disability (ID) is among the most common global disorders, yet etiology is unknown in ~30% of patients despite clinical assessment. Whole genome sequencing (WGS) is able to interrogate the entire genome, providing potential to diagnose idiopathic patients. METHODS: We conducted WGS on eight children with idiopathic ID and brain structural defects, and their normal parents; carrying out an extensive data analyses, using standard and discovery approaches...
May 24, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28507453/erratum-to-suppression-of-spry4-enhances-cancer-stem-cell-properties-of-human-mda-mb-231-breast-carcinoma-cells
#16
Hongyu Jing, Lucy Liaw, Robert Friesel, Calvin Vary, Shucheng Hua, Xuehui Yang
[This corrects the article DOI: 10.1186/s12935-016-0292-7.].
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28446723/up-regulation-of-long-non-coding-rna-spry4-it1-promotes-tumor-cell-migration-and-invasion-in-lung-adenocarcinoma
#17
Xia Zhang, Qingyan Chi, Zhenhua Zhao
Long non-coding RNAs (lncRNAs) play important role in a variety of biological processes, and are tightly associated with tumorigenesis and cancer prognosis. However, the potential power of lncRNA signatures in predicting survival of patients with lung adenocarcinoma (LUAD) has not been investigated. Here, we identified a four-lncRNA signature (SPRY4-IT1, LINC00941,GPR158-AS1 and KCNK15-AS1) displaying prognostic values for LUAD using The Cancer Genome Atlas (TCGA) dataset. Based on the four-lncRNA signature, the LUAD patients can be classified into high-risk and low-risk groups with significantly different survival...
April 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28446530/long-non-coding-rnas-and-their-role-in-metastasis
#18
REVIEW
Ulrich H Weidle, Fabian Birzele, Gwen Kollmorgen, Rüdiger Rüger
The perception of long non-coding RNAs as chunk RNA and transcriptional noise has been steadily replaced by their role as validated targets for a diverse set of physiological processes in the past few years. However, for the vast majority of lncRNAs their precise mode of action and physiological function remain to be uncovered. A large body of evidence has revealed their essential role in all stages of cancirogenesis and metastasis. In this review we focus on the role of lncRNAs in metastasis. We grouped selected lncRNAs into three categories based on in vitro and in vivo mode of action-related studies and clinical relevance for metastasis...
May 2017: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/28410241/prognostic-role-of-the-long-non-coding-rna-spry4-intronic-transcript-1-in-patients-with-cancer-a-meta-analysis
#19
Miaojuan Wang, Xuejun Dong, Yi Feng, Honggang Sun, Ningping Shan, Tao Lu
Recent studies have emphasized the important role of long non-coding RNAs (lncRNAs) in cancer development. The present study performed a meta-analysis to investigate whether lncRNA, SPRY4 Intronic Transcript 1(SPRY4-IT1) can be served as a potential biomarker for prognosis in human cancers. The eligible studies were collected by searching multiple online databases (Pubmed, EMBASE, CNKI, Web of Science and Google Scholar) and meta-analysis was performed to explore the association between the expression levels of SPRY4-IT1 and overall survival (OS), disease-free survival (DFS) and clinicopathological parameters...
May 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28394519/-genetic-risk-factors-for-sporadic-germ-cell-testicular-tumors
#20
M V Nemtsova, E V Ivkin, A A Tryakin, V V Rudenko, I S Dantsev, S A Tyulyandin, O B Loran
INTRODUCTION: Approximately 95% of all testicular cancers are testicular germ cell tumors (GCTTs), represented by seminoma and nonseminoma germ cell testicular cancer. There is a hypothesis that the formation of GCTTs begins in early embryogenesis being a part of testicular dysgenesis syndrome (TDS). AIM: To determine the role of genetic factors in the development of GCTTs. MATERIALS AND METHODS: We studied the frequency of alleles and genotypes KITLG (rs995030, rs1508595), SPRY4 (rs4624820, rs6897876) and BAK1 (rs210138) in 97 fertile men (control), and 73 patients with GCTTs (34 seminoma and 39 nonseminoma)...
April 2017: Urologii︠a︡
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