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https://www.readbyqxmd.com/read/29330027/selective-estrogen-receptor-modulator-ormeloxifene-suppresses-embryo-implantation-via-inducing-mir-140-and-targeting-insulin-like-growth-factor-1-receptor-in-rat-uterus
#1
Vijay K Sirohi, Kanchan Gupta, Rohit Kumar, Vinay Shukla, Anila Dwivedi
Ormeloxifene, the non-steroidal SERM contraceptive, inhibits endometrial receptivity and embryo implantation via countering nidatory estrogen. However, the molecular mechanism of ormeloxifene action responsible for its contraceptive efficacy still remains unclear. Herein, we aimed to identify the miRNAs modulated under the influence of ormeloxifene and to explore their role in endometrial receptivity and embryo implantation. By doing microRNA sequencing analysis, a total of 168 miRNAs were found to be differentially expressed in uterine tissue of ormeloxifene-treated rats, on day 5 (10:00 h) of pregnancy i...
January 9, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29327380/effects-of-deficiency-and-surplus-dietary-threonine-on-reproductive-performance-of-primiparous-pregnant-gilts
#2
M Shi, T Liu, T Li, H Wang, T Yuan, D Li, J Wang
Dietary threonine imbalance is known to impair reproductive performances of gestating sows, but the underlying mechanisms are largely unknown. In this study, effects of deficiency and surplus dietary threonine during gestation on reproductive performance, serum metabolites and hormones concentration, and colostral nutrient and immunoglobulin contents of primiparous sows were investigated. Ninety primiparous pregnant gilts were assigned to one of the three dietary treatments with different standardized ileal digestible threonine/lysine ratios at 0...
January 11, 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29325773/how-safe-is-metformin-when-initiated-in-early-pregnancy-a-retrospective-5-year-study-of-pregnant-women-with-gestational-diabetes-mellitus-from-india
#3
Vanlalhruaii, Riddhi Dasgupta, Roshna Ramachandran, Jiji E Mathews, Annie Regi, Niranjan Thomas, Vijay Gupta, P Visalakshi, H S Asha, Thomas Paul, Nihal Thomas
BACKGROUND: The initiation of metformin in early pregnancy in Gestational Diabetes mellitus(GDM) remains controversial. The aim of our study was to assess the influence of Metformin on maternal and fetal outcomes when initiated within the first trimester of pregnancy in GDM. METHODS AND MATERIALS: A retrospective analysis of 540 women with diabetes complicating pregnancy (IADPSG criteria) over five years(January 2011 to May 2016)was done. The study population comprised of patients initiated on a)metformin within the first trimester (Group A:n=186),b) metformin after the first trimester(Group B:n=203) and c)insulin at any time during their pregnancy(Group C:n=151)...
January 8, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29324776/effect-of-a-lifestyle-intervention-in-obese-infertile-women-on-cardiometabolic-health-and-quality-of-life-a-randomized-controlled-trial
#4
Lotte van Dammen, Vincent Wekker, Anne M van Oers, Meike A Q Mutsaerts, Rebecca C Painter, Aeilko H Zwinderman, Henk Groen, Cornelieke van de Beek, Anneke C Muller Kobold, Walter K H Kuchenbecker, Ron van Golde, Gerrit J E Oosterhuis, Niels E A Vogel, Ben Willem J Mol, Tessa J Roseboom, Annemieke Hoek
BACKGROUND: The prevalence of obesity, an important cardiometabolic risk factor, is rising in women. Lifestyle improvements are the first step in treatment of obesity, but the success depends on factors like timing and motivation. Women are especially receptive to advice about lifestyle before and during pregnancy. Therefore, we hypothesize that the pre-pregnancy period provides the perfect window of opportunity to improve cardiometabolic health and quality of life of obese infertile women, by means of a lifestyle intervention...
2018: PloS One
https://www.readbyqxmd.com/read/29324603/pregnancy-associated-hypertension-and-offspring-cardiometabolic-health
#5
Madeline Murguia Rice, Mark B Landon, Michael W Varner, Brian M Casey, Uma M Reddy, Ronald J Wapner, Dwight J Rouse, Alan T N Tita, John M Thorp, Edward K Chien, George Saade, Alan M Peaceman, Sean C Blackwell
OBJECTIVE: To evaluate whether pregnancy-associated hypertension (gestational hypertension and preeclampsia) was associated with the cardiometabolic health of young offspring. METHODS: This was a prospective observational follow-up study from 2012 to 2013 of children born to women previously enrolled in a mild gestational diabetes mellitus treatment trial or nongestational diabetes mellitus observational study. At 5-10 years after birth, children were examined and fasting blood samples obtained to determine the following cardiometabolic risk factors: blood pressure (BP), high-density lipoprotein cholesterol, triglycerides, glucose, homeostatic model assessment of insulin resistance, waist circumference, and body mass index (BMI)...
January 9, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29324300/hippocampal-insulin-resistance-links-maternal-obesity-with-impaired-neuronal-plasticity-in-adult-offspring
#6
Lisa Schmitz, Rebecca Kuglin, Inga Bae-Gartz, Ruth Janoschek, Sarah Appel, Andrea Mesaros, Igor Jakovcevski, Christina Vohlen, Marion Handwerk, Regina Ensenauer, Jörg Dötsch, Eva Hucklenbruch-Rother
OBJECTIVE: Maternal obesity and a disturbed metabolic environment during pregnancy and lactation have been shown to result in many long-term health consequences for the offspring. Among them, impairments in neurocognitive development and performance belong to the most dreaded ones. So far, very few mechanistic approaches have aimed to determine the responsible molecular events. METHODS: In a mouse model of maternal diet-induced obesity and perinatal hyperinsulinemia, we assessed adult offspring's hippocampal insulin signaling as well as concurrent effects on markers of hippocampal neurogenesis, synaptic plasticity and function using western blotting and immunohistochemistry...
December 28, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29320884/correlation-between-third-trimester-glycemic-variability-in-non-insulin-dependent-gestational-diabetes-mellitus-and-adverse-pregnancy-and-fetal-outcomes
#7
Wanwadee Sapmee Panyakat, Chayawat Phatihattakorn, Apiradee Sriwijitkamol, Prasert Sunsaneevithayakul, Amprapha Phaophan, Aporn Phichitkanka
BACKGROUND: Gestational diabetes mellitus (GDM) is a pregnancy-related metabolic complication. Despite optimal glycemic control from self-monitoring blood glucose (SMBG) in non-insulin-dependent GDM, variations in pregnancy outcomes persist. Glycemic variability is believed to be a factor that causes adverse pregnancy outcomes. Continuous glucose monitoring system (CGMS) detects interstitial glucose values every 5 minutes, and glycemic variability data from CGMS during the third trimester may be a predictor of fetal birth weight and pregnancy outcomes...
January 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29313572/cardio-metabolic-risk-profile-in-women-with-previous-history-of-pre-eclampsia
#8
Jalees Fatma, Ritu Karoli, Zeba Siddiqui, H P Gupta, Ashok Chandra, Mahima Pandey
Introduction: Preeclampsia is one of the leading causes of maternal and neonatal morbidity and mortality. However there is growing evidence that there are differences during the post partum period between subjects with prior preeclampsia and prior uncomplicated pregnancy and women with a history of preeclampsia are more likely to develop cardiovascular disease later in life. The aim of our study was to assess the cardio- metabolic risk profile in women with previous history of pre-eclampsia and to their counterparts who had normal pregnancy...
September 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29310734/differential-methylation-of-insulin-like-growth-factor-2-in-offspring-of-physically-active-pregnant-women
#9
M R Marshall, N Paneth, J A Gerlach, L M Mudd, L Biery, D P Ferguson, J M Pivarnik
Several studies have suggested that maternal lifestyle during pregnancy may influence long-term health of offspring by altering the offspring epigenome. Whether maternal leisure-time physical activity (LTPA) during pregnancy might have this effect is unknown. The purpose of this study was to determine the relationship between maternal LTPA during pregnancy and offspring DNA methylation. Participants were recruited from the Archive for Research on Child Health study. At enrollment, participants' demographic information and self-reported LTPA during pregnancy were determined...
January 9, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29310617/exercise-training-during-pregnancy-reduces-circulating-insulin-levels-in-overweight-obese-women-postpartum-secondary-analysis-of-a-randomised-controlled-trial-the-etip-trial
#10
Kirsti K Garnæs, Siv Mørkved, Kjell Å Salvesen, Øyvind Salvesen, Trine Moholdt
BACKGROUND: The primary aim was to investigate if supervised exercise training during pregnancy could reduce postpartum weight retention (PPWR) three months after delivery in overweight and obese women. We also measured circulating markers of cardiometabolic health, body composition, blood pressure, and physical activity level. METHODS: This was a secondary analysis of a randomised controlled trial in which 91 women with BMI ≥ 28 kg/m2 were allocated 1:1 to an exercise program or a control group...
January 8, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29306901/cardiometabolic-health-among-adult-offspring-of-hypertensive-pregnancies-the-cardiovascular-risk-in-young-finns-study
#11
Robyn J Tapp, Alun D Hughes, Mika Kähönen, Tien Yin Wong, Nicholas Witt, Terho Lehtimäki, Nina Hutri-Kähönen, Pinki Sahota, Markus Juonala, Olli T Raitakari
BACKGROUND: Cardiometabolic health among adult offspring of hypertensive disorders of pregnancy (HDP) is relatively unknown. We hypothesized that offspring of HDP would have abnormalities in the retinal microvasculature and cardiac structure by midadulthood. METHODS AND RESULTS: The Cardiovascular Risk in Young Finns Study included randomly selected children from 5 Finnish university cities. The mean age of participants was 40 years (range 34-49 years) at the time of retinal photography and cardiac assessment...
January 6, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29298286/new-criteria-for-gestational-diabetes-mellitus-do-they-impact-the-outcome
#12
Julia Zareba-Szczudlik, Dominika Pykalo-Gawinska, Cieszymierz Gawinski, Zbigniew Lewandowski, Aneta Malinowska-Polubiec, Agnieszka Dobrowolska-Redo, Krzysztof Czajkowski, Jan Wilczynski, Ewa Romejko-Wolniewicz
OBJECTIVE: The aim of the study was to compare the perinatal outcome of pregnancies in mothers who were diagnosed with gestational diabetes mellitus (GDM) with previous versus current Polish Gynecological Society (PTG) criteria. METHODS: 475 patients were divided into three groups. In group A, the patients only met the previous PTG criteria for a GDM diagnosis, i.e., those with a blood glucose level of 140-152 mg/dl 2 hours after administration, a fasting glucose level <92 mg/dl, and a blood glucose level <180 mg/dl 1 hour after administration...
December 4, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29289991/effects-of-dietary-advice-on-insulin-like-growth-factors-among-healthy-newborns
#13
Emre Özgür Bulduk, Sıdıka Bulduk, Burcu Biral Coşkun
OBJECTIVES: In fetal life, insulin, insulin-like growth factor (IGF) 1, IGF 2 and IGF-binding protein (IGFBP) 3 are essential growth factors. The purpose of this study is to investigate the effects of dietary intervention on insulin-like growth factors in the cord blood of neonates. METHODS: The study involved 52 pregnant women who were followed up in Gazi University Medical School Hospital at Ankara, Turkey. They were randomly divided into two groups: The experimental group was involved in nutrition education...
December 30, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29289537/early-postpartum-metabolic-syndrome-in-women-with-or-without-gestational-diabetes-results-from-life-after-gestational-diabetes-ahvaz-cohort-study
#14
Sedigheh Nouhjah, Hajieh Shahbazian, Nahid Shahbazian, Shayesteh Jahanfar, Alireza Jahanshahi, Bahman Cheraghian, Zeinab Dehghan Mohammadi, Niloofar Ghodrati, Sousan Houshmandi
AIMS: This study aimed to determine the prevalence rate of metabolic syndrome and its potential risk factors, 6-12 weeks postpartum in women with GDM compared to women with normal glucose tolerance. METHODS: LAGAs is an ongoing population-based prospective cohort study that started in March 2015 in Ahvaz, Iran. During 11 months of study progression, 176 women with GDM pregnancy and 86 healthy women underwent a fasting glucose test, 75-g OGTT and fasting lipid tests at 6-12 weeks postpartum...
December 22, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29285460/prevalence-of-pharamcologically-treated-diabetes-in-term-pregnancies-in-haryana-india
#15
Bharti Kalra, Sanjay Kalra, Meenu Choudhary, Meenakshi Thakral
Gestational diabetes mellitus (GDM) is common in pregnancy. Epidemiological studies have described the prevalence of GDM in the antenatal period, but do not assess the number of women who require pharmacological therapy at term. This information is important for obstetric care providers and health planners. We reviewed indoor charts of all women admitted for delivery at a maternity center in Karnal, Haryana, India. Of the 569 participants, 0.87% had preexisting diabetes, while 1.93% were being treated with drugs for GDM (0...
November 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29285448/maternal-and-neonatal-outcome-in-mothers-with-gestational-diabetes-mellitus
#16
G Thiruvikrama Prakash, Ashok Kumar Das, Syed Habeebullah, Vishnu Bhat, Suryanarayana Bettadpura Shamanna
Introduction: Gestational diabetes mellitus (GDM) is common and is accompanied with other comorbidities. Challenges to treatment exist at our institute as it serves women with low income. This study assessed the burden of comorbidities and the outcome of GDM. Methods: This was a prospective, observational study of women with gestational diabetes attending the obstetrics department from September 2012 to April 2014. GDM was diagnosed based on the International Association of Diabetes and Pregnancy Study Groups criteria...
November 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29282998/clinical-significance-of-neuregulin-4-nrg4-in-gestational-diabetes-mellitus
#17
Meryem Kurek Eken, Cigdem Yayla Abide, Gulcin Sahin Ersoy, Tugba Altun Ensari, Oya Pekin, Ozge Cevik
OBJECTIVE: Gestational diabetes mellitus (GDM) is defined as glucose intolerance detected during pregnancy. GDM is increasing worldwide and is associated with adverse maternal and fetal outcomes. Neuregulin 4 (NGR4) is epidermal growth factor like signaling molecule. It plays an important role in cell to cell communication furthermore recent studies indicate that NRG4 may work as a novel adipokine with a possible role in maintaining energy and metabolic homeostasis. The aim of the present study was to assess serum NRG4 levels along with several metabolic parameters in patients diagnosed with gestational diabetic mellitus...
December 28, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29280739/novel-modulators-of-the-growth-hormone-insulin-like-growth-factor-axis-pregnancy-associated-plasma-protein-a2-and-stanniocalcin-2
#18
Masanobu Fujimoto, Vivian Hwa, Andrew Dauber
Growth hormone (GH) and its mediator, insulin-like growth factor-1 (IGF-1), play a critical role in human growth. In circulation, IGF-1 is found in a ternary complex with IGF binding proteins (IGFBPs) and acid labile subunit (ALS) but little attention has been paid to the regulation of IGF-1 bioavailability. Recently, pregnancy-associated plasma protein-A2 (PAPP-A2) and stanniocalcin-2 (STC2) were identified as novel modulators of IGF-I bioavailability. PAPP-A2 is a protease which cleaves IGFBP-3 and -5, while STC2 inhibits PAPP-A and PAPP-A2 activity...
December 27, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29278829/efficacy-of-maternal-and-biological-parameters-at-the-time-of-diagnosis-of-gestational-diabetes-mellitus-in-predicting-neonatal-morbidity
#19
Guillaume Ducarme, François Desroys Du Roure, Aurélie Le Thuaut, Joséphine Grange, Jérôme Dimet, Ingrid Crepin-Delcourt
OBJECTIVE: Gestational diabetes mellitus (GDM) is independently associated with an increased risk of maternal-fetal complications. Improved glycemic control allows reducing perinatal morbidity and mortality and, specifically, the risk of macrosomia and shoulder dystocia which are the most common complications associated with GDM. Nonetheless, a need for early antenatal predictor of neonatal morbidity in women suffering from GDM is required. The objective of the study was to evaluate the efficacy of different maternal, biological, and antenatal parameters at the time of diagnosis of GDM or perinatal variables as predictors of neonatal morbidity...
December 19, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29278514/maternal-serum-placental-growth-hormone-insulin-like-growth-factors-and-their-binding-proteins-at-20-weeks-gestation-in-pregnancies-complicated-by-gestational-diabetes-mellitus
#20
Shutan Liao, Mark H Vickers, Rennae S Taylor, Mhoyra Fraser, Lesley M E McCowan, Philip N Baker, Jo K Perry
OBJECTIVE: To investigate whether maternal serum concentrations of placental growth hormone (GH-V), insulin-like growth factor (IGF) 1 and 2, and IGF binding proteins (IGFBP) 1 and 3 were altered in pregnancies complicated by gestational diabetes mellitus (GDM). METHOD: In a nested case-control study, GDM cases (n=28) and matched controls (n=28) were selected from the Screening for Pregnancy Endpoints (SCOPE) biobank in Auckland, New Zealand. Maternal serum hormone concentrations at 20 weeks of gestation were determined by enzyme-linked immunosorbent assay (ELISA)...
July 2017: Hormones: International Journal of Endocrinology and Metabolism
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