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https://www.readbyqxmd.com/read/28081146/maternal-nutrition-during-pregnancy-affects-testicular-and-bone-development-glucose-metabolism-and-response-to-overnutrition-in-weaned-horses-up-to-two-years
#1
Morgane Robles, Camille Gautier, Luis Mendoza, Pauline Peugnet, Cédric Dubois, Michèle Dahirel, Jean-Philippe Lejeune, Isabelle Caudron, Isabelle Guenon, Sylvaine Camous, Anne Tarrade, Laurence Wimel, Didier Serteyn, Hélène Bouraima-Lelong, Pascale Chavatte-Palmer
INTRODUCTION: Pregnant mares and post-weaning foals are often fed concentrates rich in soluble carbohydrates, together with forage. Recent studies suggest that the use of concentrates is linked to alterations of metabolism and the development of osteochondrosis in foals. The aim of this study was to determine if broodmare diet during gestation affects metabolism, osteoarticular status and growth of yearlings overfed from 20 to 24 months of age and/or sexual maturity in prepubertal colts...
2017: PloS One
https://www.readbyqxmd.com/read/28078553/expression-of-apoptosis-regulatory-genes-in-the-hippocampus-of-rat-neonates-born-to-mothers-with-diabetes
#2
Hossein Haghir, Javad Hami, Nassim Lotfi, Mostafa Peyvandi, Simagol Ghasemi, Mehran Hosseini
Diabetes during pregnancy impairs the development of the central nervous system (CNS) and causes cognitive and behavioral abnormalities in offspring. However, the exact mechanism by which the maternal diabetes affects the development of the brain remains to be elucidated. The aim of the present study was to investigate the effects of maternal diabetes in pregnancy on the expression of Bcl-2 and Bax genes and the numerical density of degenerating dark neurons (DNs) in the hippocampus of offspring at the first postnatal two weeks...
January 11, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28074994/-normoglycemic-diabetic-ketoacidosis-in-pregnancy-report-of-one-case
#3
Margarita Rivas M, Pamela Belmar Z, Pilar Durruty A, Lilian Sanhueza M, Gloria López S
Normoglycemic diabetic ketoacidosis should be suspected in pregnant women presenting nausea, vomiting, abdominal pain and anorexia. We report a 39 years old woman with a 32 weeks pregnancy who sought emergency care due to hyperemesis. She was hospitalized with the following diagnoses: pregnancy hypertension syndrome, gestational diabetes, morbid obesity and poor prenatal control. The evaluation of the feto-placental unit showed perception of fetal movements, non-reactive non-stress baseline record and a biophysical profile of 6/8...
October 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28073830/adiponectin-deficiency-impairs-maternal-metabolic-adaptation-to-pregnancy-in-mice
#4
Liping Qiao, Jean-Sebastien Wattez, Samuel Lee, Amanda Nguyen, Jerome Schaack, William W Hay, Jianhua Shao
Hypoadiponectinemia has been widely observed in patients with gestational diabetes. To investigate the causal role of hypoadiponectinemia in gestational diabetes, adiponectin gene knockout (Adipoq(-/-)) and wild-type (WT) mice were crossed to produce pregnant mouse models with or without adiponectin deficiency. Adenoviral vector-mediated in vivo transduction was used to reconstitute adiponectin during late pregnancy. Results showed that Adipoq(-/-) dams developed glucose intolerance and hyperlipidemia in late pregnancy...
January 10, 2017: Diabetes
https://www.readbyqxmd.com/read/28072825/dietary-chromium-restriction-of-pregnant-mice-changes-the-methylation-status-of-hepatic-genes-involved-with-insulin-signaling-in-adult-male-offspring
#5
Qian Zhang, Xiaofang Sun, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Zhixin Wang, Cuijuan Qi, Tong Wang, Xiaojing Wang
Maternal undernutrition is linked with an elevated risk of diabetes mellitus in offspring regardless of the postnatal dietary status. This is also found in maternal micro-nutrition deficiency, especial chromium which is a key glucose regulator. We investigated whether maternal chromium restriction contributes to the development of diabetes in offspring by affecting DNA methylation status in liver tissue. After being mated with control males, female weanling 8-week-old C57BL mice were fed a control diet (CON, 1...
2017: PloS One
https://www.readbyqxmd.com/read/28063291/glucogenic-treatment-creates-an-optimal-metabolic-milieu-for-the-conception-period-in-ewes
#6
C Porcu, V Pasciu, S Succu, E Baralla, M E Manca, E Serra, G G Leoni, M Dattena, G C Bomboi, G Molle, S Naitana, F Berlinguer
This study determined the influence of a short-term glucogenic nutritional treatment on circulating concentrations of glucose, insulin, insulin-like growth factor 1 (IGF-1), nonesterified fatty acids (NEFA), and urea, and on their correspondent levels in follicular fluid (FF) collected 12 h after the end of the treatment. After estrous synchronization with intravaginal progestagen-impregnated sponges, 20 Sarda ewes were randomly allocated into two experimental groups (GLU and WAT) and, from day 7 to day 10 (day 0 = day of sponge removal), the GLU group was gavaged with a glycogenic mixture, whereas the WAT group was gavaged with water (control group)...
December 11, 2016: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/28063235/a-critical-role-for-adiponectin-mediated-development-of-endometrial-luminal-epithelial-cells-during-the-peri-implantation-period-of-pregnancy
#7
Whasun Lim, Myung Jin Choi, Hyocheol Bae, Fuller W Bazer, Gwonhwa Song
Adiponectin is one of the adipokines in the collagen superfamily. It is secreted primarily by white adipocytes and influences reproductive processes including ovarian and uterine functions. Adiponectin regulates energy homeostasis, insulin sensitivity and is anti-inflammatory in various tissues. Its receptors (ADIPOR1 and ADIPOR2) are widely expressed in mammalian tissues, including porcine conceptuses and endometrial during the estrous cycle and peri-implantation period of pregnancy. However, regulatory effects of adiponectin on endometrial epithelial cells are unknown...
January 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28050707/effect-of-parental-obesity-and-gestational-diabetes-on-child-neuropsychological-and-behavioral-development-at-4%C3%A2-years-of-age-the-rhea-mother-child-cohort-crete-greece
#8
Vasiliki Daraki, Theano Roumeliotaki, Katerina Koutra, Vaggelis Georgiou, Mariza Kampouri, Andriani Kyriklaki, Marina Vafeiadi, Stathis Papavasiliou, Manolis Kogevinas, Leda Chatzi
Studies have suggested an association between maternal obesity pre-pregnancy and gestational diabetes (GDM) with impaired offspring neurodevelopment, but it is not clear if these associations are explained by shared familiar characteristics. We aimed to assess the associations of maternal and paternal obesity, maternal glucose intolerance in early pregnancy and GDM, with offspring neurodevelopment at 4 years of age. We included 772 mother-child pairs from the "Rhea" Mother-Child cohort in Crete, Greece. Data on maternal/paternal body mass index (BMI) and maternal fasting serum samples for glucose and insulin measurements were collected at 12 weeks of gestation...
January 3, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28050671/adiponectin-and-leptin-gene-polymorphisms-in-women-with-gestational-diabetes-mellitus
#9
Andrzej Pawlik, Joanna Teler, Agnieszka Maciejewska, Marek Sawczuk, Krzysztof Safranow, Violetta Dziedziejko
PURPOSE: Gestational diabetes mellitus (GDM) is the glucose intolerance occurring during pregnancy. The prevalence of GDM is increased in obese women. Leptin and adiponectin are adipokines that play an important role in the regulation of insulin secretion and glucose and lipid metabolism. The aim of this study was to examine the association between adiponectin and leptin gene polymorphisms and the development of GDM. METHODS: This case-control study included 204 pregnant women with GDM and 207 pregnant women with normal glucose tolerance (NGT)...
January 3, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28049695/dysregulated-dna-methyltransferase-3a-upregulates-igfbp5-to-suppress-trophoblast-cell-migration-and-invasion-in-preeclampsia
#10
Yuanhui Jia, Ting Li, Xiaojie Huang, Xianghong Xu, Xinyao Zhou, Linyan Jia, Jingping Zhu, Dandan Xie, Kai Wang, Qian Zhou, Liping Jin, Jiqin Zhang, Tao Duan
Preeclampsia is a unique multiple system disorder during human pregnancy, which affects ≈5% to 8% of pregnancies. Its risks and complications have become the major causes of maternal and fetal morbidity and mortality. Although abnormal placentation to which DNA methylation dysregulation is always linked is speculated to be one of the reasons causing preeclampsia, the underlying mechanisms still remain elusive to date. Here we revealed that aberrant DNA methyltransferase 3A (DNMT3A) plays a critical role in preeclampsia...
January 3, 2017: Hypertension
https://www.readbyqxmd.com/read/28049284/prevention-of-type-2-diabetes-mellitus-in-women-with-previous-gestational-diabetes-mellitus
#11
REVIEW
Joon Ho Moon, Soo Heon Kwak, Hak C Jang
Gestational diabetes mellitus (GDM), defined as any degree of glucose intolerance with onset or first recognition during pregnancy, is characterized by underlying maternal defects in the β-cell response to insulin during pregnancy. Women with a previous history of GDM have a greater than 7-fold higher risk of developing postpartum diabetes compared with women without GDM. Various risk factors for postpartum diabetes have been identified, including maternal age, glucose levels in pregnancy, family history of diabetes, pre-pregnancy and postpartum body mass index, dietary patterns, physical activity, and breastfeeding...
January 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28042411/clomiphene-citrate-treatment-cycle-outcomes-of-polycystic-ovary-syndrome-patients-based-on-basal-high-sensitive-c-reactive-protein-levels-a-cross-sectional-study
#12
Serkan Kahyaoglu, Omer Hamid Yumuşak, Sebnem Ozyer, Meryem Kuru Pekcan, Merve Erel, Mahmut Nedim Cicek, Salim Erkaya, Yasemin Tasci
BACKGROUND: Polycystic ovary syndrome (PCOS) is highly associated with an ovulatory infertility, features of the metabolic syndrome, including obesity, insulin resistance and dyslipidemia. Serum concentrations of high sensitive C-reactive protein (hs-CRP) were significantly higher in obese than in non-obese PCOS patients at baseline, suggesting a relationship between elevated hs-CRP levels and obesity. The aim of this study was to evaluate whether cycle day 3 hs-CRP levels before clomiphene citrate (CC) treatment would predict cycle outcomes in women with PCOS...
January 2017: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/28040126/prediction-of-gestational-diabetes-mellitus-at-first-trimester-in-low-risk-pregnancies
#13
Pınar Kumru, Resul Arisoy, Emre Erdogdu, Oya Demirci, Mustecep Kavrut, Cem Ardıc, Nihan Aslaner, Aysen Ozkoral, Aktug Ertekin
OBJECTIVE: We aimed to assess the relationship among the sex hormone-binding globulin (SHBG), homeostasis model assessment (HOMA), glycosylated hemoglobin (HbA1c), and cholesterol panel values to predict subsequent gestational diabetes mellitus (GDM) in low-risk pregnancies. MATERIALS AND METHODS: Thirty-eight pregnant women with GDM and 295 low-risk pregnant women without GDM were included in this study. Maternal blood samples were obtained during the first trimester examination to determine the SHBG, HbA1c, fasting blood glucose, insulin, thyroid stimulating hormone (TSH), free thyroxine, total cholesterol, triglycerides (TG), high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol (LDL-C) levels...
December 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28035763/circulating-milk-fat-globule-epidermal-growth-factor-8-levels-are-increased-in-pregnancy-and-gestational-diabetes-mellitus
#14
Yuanyuan Li, Wenzhuo Ran, Jiaqiang Zhang, Shi Chen, Yihang Li, Deng Luo, Chen Wang, Weiping Jia
AIMS/INTRODUCTION: Milk fat globule-epidermal growth factor 8 (MFG-E8) is the key mediator in anti-inflammatory responses that facilitate phagocytosis of apoptotic cells and play an essential role in type 2 diabetes and pregnancy, both of which are under a low-grade inflammatory state. However, the action of MFG-E8 in gestational diabetes mellitus (GDM) is unclear. We measured for the first time plasma MFG-E8 levels in pregnancy and GDM, and elucidated possible relationships between its plasma levels and various metabolic parameters...
December 30, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28035757/papp-a-a-promising-therapeutic-target-for-healthy-longevity
#15
REVIEW
Cheryl A Conover, Claus Oxvig
Pregnancy-associated plasma protein-A (PAPP-A) is a proteolytic enzyme that was discovered to increase local insulin-like growth factor (IGF) availability for receptor activation through cleavage of inhibitory IGF binding proteins (IGFBPs). Reduced IGF signaling has been associated with increased lifespan and healthspan. Therefore, inhibition of PAPP-A represents a novel approach to indirectly decrease the availability of bioactive IGF. Here, we will review data in support of PAPP-A as a therapeutic target to promote healthy longevity...
December 29, 2016: Aging Cell
https://www.readbyqxmd.com/read/28034892/how-i-treat-anemia-in-pregnancy-iron-cobalamin-and-folate
#16
Maureen M Achebe, Anat Gafter-Gvili
Anemia of pregnancy is considered a global health problem, affecting almost 50% of pregnant women. Anemia is an important risk factor for both fetal and maternal morbidity. The purpose of this article is to discuss diagnosis and management of the most frequent causes of anemia in pregnancy: iron, cobalamin and folate deficiencies. This paper considers three clinical cases. Iron deficiency is the most common cause. The laboratory tests that define iron deficiency, the recognition of developmental delays and cognitive abnormalities in iron-deficient neonates and the literature addressing the efficacy and safety of intravenous iron in pregnancy are reviewed...
December 29, 2016: Blood
https://www.readbyqxmd.com/read/28027635/placental-weight-ratio-affects-placental-mrna-expression-of-insulin-like-growth-factor-i-and-long-isoform-of-the-leptin-receptor-in-plasmodium-falciparuminfected-pregnant-women
#17
Sukma Oktavianthi, Leily Trianty, Rintis Noviyanti, Hidayat Trimarsanto, Herawati Sudoyo, Safarina G Malik
BACKGROUND AND OBJECTIVES: Plasmodium falciparum infection during pregnancy is characterised by placental inefficiency caused by infected erythrocyte sequestration. Reduced placental efficiency leads to placental intrauterine adaptation for sustaining fetal growth, which is reflected by changes in the expression of placental genes involved in intrauterine growth regulation. Therefore, we aimed to determine whether the placental weight ratio, an indicator of placental efficiency, affects the placental expression of the components of the insulin-like growth factor axis and leptin signalling pathway in P...
December 2016: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28026897/pregnancy-outcome-of-gestational-diabetes-mellitus-using-a-structured-model-of-care-wings-project-wings-10
#18
Ram Uma, Balaji Bhavadharini, Harish Ranjani, Manni Mohanraj Mahalakshmi, Ranjit Mohan Anjana, Ranjit Unnikrishnan, Arivudainambi Kayal, Belma Malanda, Anne Belton, Viswanathan Mohan
AIM: To evaluate the impact of a structured model of care (MOC) prepared for resource-constrained settings, on the pregnancy outcomes of Asian Indian women with gestational diabetes mellitus (GDM). METHODS: Pregnant women were screened under the Women in India with GDM Strategy (WINGS) MOC for GDM using the International Association of Diabetes and Pregnancy Study Groups criteria. Women with GDM went through a structured MOC that included medical nutrition therapy (MNT), regular physical activity (PA); and insulin when indicated...
December 27, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28026098/risk-factors-for-preeclampsia-in-infertile-chinese-women-with-polycystic-ovary-syndrome-a-prospective-cohort-study
#19
Hexia Xia, Ruixiu Zhang, Xiaoli Sun, Lu Wang, Wei Zhang
To explore preconception risk factors for preeclampsia (PE) in women with polycystic ovary syndrome (PCOS), a prospective cohort study was conducted in 92 infertile Chinese women with PCOS who had a singleton pregnancy by ovulation induction and were followed up for 6 weeks after delivery. The patients underwent assessment of physical, endocrine, and metabolic features before ovulation induction. Fifteen (16.3%) patients were diagnosed with PE. Logistic regression analysis showed that preconception sex hormone-binding globulin (SHBG), insulin level at 120 minutes, and body mass index were three independent risk factors for PE (odds ratio [OR], 0...
December 27, 2016: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28017702/arsenite-in-drinking-water-produces-glucose-intolerance-in-pregnant-rats-and-their-female-offspring
#20
María Marta Bonaventura, Nadia Soledad Bourguignon, Marianne Bizzozzero, Diego Rodriguez, Clara Ventura, Claudia Cocca, Carlos Libertun, Victoria Adela Lux-Lantos
Drinking water is the main source of arsenic exposure. Chronic exposure has been associated with metabolic disorders. Here we studied the effects of arsenic on glucose metabolism, in pregnant and post-partum of dams and their offspring. We administered 5 (A5) or 50 (A50) mg/L of sodium arsenite in drinking water to rats from gestational day 1 (GD1) until two months postpartum (2MPP), and to their offspring from weaning until 8 weeks old. Liver arsenic dose-dependently increased in arsenite-treated rats to levels similar to exposed population...
December 23, 2016: Food and Chemical Toxicology
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