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Intraarterial thrombolysis

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https://www.readbyqxmd.com/read/27664152/endovascular-treatment-of-thrombosis-and-embolism
#1
Ahmet Yigit Goktay, Cagin Senturk
Deep venous thrombosis (DVT) is a common disorder with a significant mortality rate. Successful endovascular treatment of acute DVT is most likely to be achieved in patients with recently formed thrombus, (<10-14 days) with acute iliofemoral DVT. Endovascular treatment options include: Catheter-directed thrombolysis (CDT), pharmacomechanical catheter-directed thrombolysis (PCDT), percutaneous aspiration thrombectomy (PAT), vena cava filter protection, venous balloon dilatation and venous stent implantation...
September 24, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27570387/factors-influencing-nonadministration-of-thrombolytic-therapy-in-early-arrival-strokes-in-a-university-hospital-in-hyderabad-india
#2
Lalitha Pidaparthi, Anitha Kotha, Venkat Reddy Aleti, Abhijeet Kumar Kohat, Mridula R Kandadai, Suryaprabha Turaga, Jabeen A Shaik, Suvarna Alladi, Meena A Kanikannan, Borgohain Rupam, Subhash Kaul
BACKGROUND: It is a well-known fact that very few patients of stroke arrive at the hospital within the window period of thrombolysis. Even among those who do, not all receive thrombolytic therapy. OBJECTIVE: The objectives of this study were to determine the proportion of early arrival ischemic strokes (within 6 h of stroke onset) in our hospital and to evaluate the causes of nonadministration of intravenous and/or intraarterial thrombolysis in them. MATERIALS AND METHODS: Data of all early arrival acute stroke patients between January 2010 and January 2015 were included...
July 2016: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/27562620/feasibility-and-midterm-results-of-endovascular-treatment-of-hepatic-artery-occlusion-within-24-hours-after-living-donor-liver-transplantation
#3
In Joon Lee, Seong Hoon Kim, Seung Duk Lee, Jae Hwan Lee, Hyun Beom Kim
PURPOSE: To evaluate the feasibility and midterm results of endovascular treatment of hepatic artery occlusion within 24 hours after living-donor liver transplantation (LDLT). MATERIALS AND METHODS: From January 2012 to June 2014, 189 consecutive patients at a single institution underwent LDLT with right-lobe grafts. Among them, 10 were diagnosed with hepatic artery occlusion within 24 hours after LDLT. All 10 underwent endovascular treatment, including drug-eluting stent placement (n = 2), intraarterial thrombolysis (n = 5), or both (n = 3)...
August 22, 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27363299/catheter-directed-intraarterial-thrombolysis-as-part-of-a-multidisciplinary-management-protocol-of-frostbite-injury
#4
Sidhartha Tavri, Suvranu Ganguli, Roy G Bryan, Jeremy Goverman, Raymond Liu, Zubin Irani, T Gregory Walker
PURPOSE: To evaluate intraarterial catheter-directed thrombolysis for prediction and prevention of delayed surgical amputation as part of multidisciplinary management of frostbite injury. MATERIALS AND METHODS: A retrospective review was performed of 13 patients (11 men, 2 women; median age, 33.4 y; range, 8-62 y) at risk of tissue loss secondary to frostbite injury and treated with catheter-directed tissue plasminogen activator (t-PA) thrombolysis. Amputation data were assessed on follow-up (mean, 23 mo; range, 9-83 mo)...
August 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27160892/ticagrelor-versus-aspirin-in-acute-stroke-or-transient-ischemic-attack
#5
RANDOMIZED CONTROLLED TRIAL
S Claiborne Johnston, Pierre Amarenco, Gregory W Albers, Hans Denison, J Donald Easton, Scott R Evans, Peter Held, Jenny Jonasson, Kazuo Minematsu, Carlos A Molina, Yongjun Wang, K S Lawrence Wong
BACKGROUND: Ticagrelor may be a more effective antiplatelet therapy than aspirin for the prevention of recurrent stroke and cardiovascular events in patients with acute cerebral ischemia. METHODS: We conducted an international double-blind, controlled trial in 674 centers in 33 countries, in which 13,199 patients with a nonsevere ischemic stroke or high-risk transient ischemic attack who had not received intravenous or intraarterial thrombolysis and were not considered to have had a cardioembolic stroke were randomly assigned within 24 hours after symptom onset, in a 1:1 ratio, to receive either ticagrelor (180 mg loading dose on day 1 followed by 90 mg twice daily for days 2 through 90) or aspirin (300 mg on day 1 followed by 100 mg daily for days 2 through 90)...
July 7, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27143201/-clinical-analysis-of-difficult-intraarterial-mechanical-thrombectomy-in-patients-with-acute-ischemic-stroke
#6
Juan Du, Yongqiang Cui, Zheng Wu, Guiping Wang, Xiangkai Kong, Xiaofeng Zhang, Wenbo Duan, Yiling Cai
OBJECTIVE: To investigate the causes and strategy of difficult intraarterial mechanical thrombectomy (≥3 times) in patients with acute ischemic stroke (AIS). METHODS: The clinical data of 8 cases of AIS with thrombectomy ≥3 times admitted in Department of Neurology, the 306(th) Hospital of People's Liberation Army from June to October in 2015 was analyzed retrospectively. There were 7 male and 1 female patients, aged from 38 to 86 years with an average age of (70±15) years, in which 5 cases were cardiogenic cerebral embolism and 3 cases were large artery atherosclerotic infarction...
May 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/26683822/endovascular-intracranial-treatment-of-acute-ischemic-strokes
#7
L Rangel-Castilla, K V Snyder, A H Siddiqui, E I Levy, L N Hopkins
Acute ischemic stroke (AIS) is the leading cause of long-term disability and the second cause of death worldwide. Intravenous (IV) tissue plasminogen activator (tPA) remains the only FDA-approved treatment for AIS. The use of IV tPA in AIS related to large-vessel occlusion (LVO) has shown low recanalization rates and poor clinical outcomes. Over the last decade, endovascular treatment has demonstrated safety and effectiveness in the management of LVO-associated AIS due to the evolution of endovascular techniques and technologies, beginning with intraarterial thrombolysis, aspiration, self- expanding intracranial stents, and now retrievable stents...
December 18, 2015: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/26476269/safety-and-effectiveness-of-adjunctive-intra-arterial-abciximab-in-the-management-of-acute-limb-ischemia
#8
Gregory G Salzler, Ashley Graham, Peter H Connolly, Darren B Schneider, Andrew J Meltzer
BACKGROUND: Contemporary endovascular management of acute limb ischemia (ALI) generally consists of tissue plasminogen activator (tPA) based catheter-directed thrombolysis (CDT) with or without pharmacomechanical thrombectomy (PMT). Although abciximab (Reopro), a GPIIb/IIIa receptor antagonist, is widely used in coronary revascularization, its safety and effectiveness in the treatment of ALI are unknown. Here, we review our contemporary experience with the endovascular management of ALI and assess the safety and effectiveness of abciximab...
January 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/26301032/hyperacute-carotid-stent-thrombosis-during-emergent-revascularization-treated-with-intraarterial-eptifibatide-after-systemic-administration-of-recombinant-tissue-plasminogen-activator
#9
Grant C Sorkin, Travis M Dumont, Maxim Mokin, Jorge L Eller, Sabareesh K Natarajan, Elad I Levy, Adnan H Siddiqui
UNLABELLED: A 57-year-old woman with National Institutes of Health Stroke Scale (NIHSS) score of 26 was found to have an acute left carotid occlusion with tandem left M1 thrombus within 1.5 hours of symptom onset. After no neurologic improvement following standard-dose intravenous (IV) recombinant tissue plasminogen activator (rtPA), emergent neuroendovascular revascularization with carotid stenting and intracranial thrombectomy were performed under conscious sedation. Thrombolysis in myocardial infarction (TIMI)-3 flow restoration and symptom resolution were achieved postprocedure; however, complete carotid stent thrombosis was noted on final angiographic runs (25 minutes later), correlating with neurologic decline...
July 2015: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/26190188/intra-arterial-thrombolysis-for-hepatic-artery-thrombosis-following-liver-transplantation
#10
Matthew J Kogut, David S Shin, Siddharth A Padia, Guy E Johnson, Daniel S Hippe, Karim Valji
PURPOSE: Hepatic artery thrombosis (HAT) is a major cause of morbidity and death following liver transplantation. The purpose of this study was to evaluate the safety and efficacy of intra-arterial thrombolysis (IAT) in liver transplant recipients with HAT. MATERIALS AND METHODS: Adult liver transplant recipients who underwent attempted IAT for HAT were identified. This included patients with early and late HAT (occurring less than or greater than 30 d after transplantation)...
September 2015: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/26179631/a-mobile-stroke-treatment-unit-for-field-triage-of-patients-for-intraarterial-revascularization-therapy
#11
Russell Cerejo, Seby John, Andrew B Buletko, Ather Taqui, Ahmed Itrat, Natalie Organek, Sung-Min Cho, Lila Sheikhi, Ken Uchino, Farren Briggs, Andrew P Reimer, Stacey Winners, Gabor Toth, Peter Rasmussen, Muhammad S Hussain
INTRODUCTION: Favorable outcomes in intraarterial therapy (IAT) for acute ischemic stroke (AIS) are related to early vessel recanalization. The mobile stroke treatment unit (MSTU) is an on-site, prehospital, treatment team, laboratory, and CT scanner that reduces time to treatment for intravenous thrombolysis and may also shorten time to IAT. METHODS: Using our MSTU database, we identified patients that underwent IAT for AIS. We compared the key time metrics to historical controls, which included patients that underwent IAT at our institution six months prior to implementation of the MSTU...
November 2015: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/25944512/contrast-extravasation-mimics-cerebral-hemorrhage-in-acute-ischemic-stroke-after-solitaire-fr-clot-retrieval-and-intraarterial-thrombolysis-a-case-report
#12
LETTER
Ying Mao, Guang-Xian Nan, Li Zhang, Yu-Jing Huang
No abstract text is available yet for this article.
December 2015: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/25890921/endovascular-treatment-of-acute-ischemic-stroke-own-experience
#13
Daniel Knap, Maciej Honkowicz, Tomasz Kirmes, Marcin Koroński, Mateusz Bukański, Marzena Kysiak, Bartosz Kadłubicki, Izabela Dymon, Dominik Sieroń, Jan Baron
OBJECTIVE: Presentation of the own experience in the treatment of ischemic stroke using endovascular methods of simultaneous evaluation of their effectiveness and safety. MATERIALS AND METHODS: The retrospective study involved a group of 18 patients hospitalized in 2005-2012 who were treated with intraarterial thrombolysis and mechanical thrombectomy. Overall there were 24 procedures performed. The investigated group consisted of seven (38.89%) women and 11 (61...
2015: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/25692110/impacts-of-rapid-recanalization-and-collateral-circulation-on-clinical-outcome-after-intraarterial-thrombolysis
#14
Hye Seon Jeong, Hyon-Jo Kwon, Hee-Jung Song, Hyeon-Song Koh, Yong Soo Kim, Ju Hun Lee, Jee Eun Shin, Suk Hoon Lee, Jei Kim
BACKGROUND AND PURPOSE: Rapid recanalization might improve clinical outcomes after intraarterial thrombolysis (IAT) for acute ischemic stroke patients with collateral circulation. We determined whether rapid recanalization and collateral circulation affect clinical outcomes after IAT. METHODS: We retrospectively evaluated the clinical and radiological data of 134 consecutive patients who underwent IAT for intracranial artery occlusion. The interval from symptom onset to recanalization after IAT (onset-to-recanalization time) as an estimate of the probability of good clinical outcome (modified Rankin scale 0-2) was calculated in patients with collateral circulation in the ischemic hemisphere, which was rated poor (0/1 American Society of Interventional and Therapeutic Neuroradiology criteria) or good (2-4)...
January 2015: Journal of Stroke
https://www.readbyqxmd.com/read/25585838/clinical-results-of-intraarterial-thrombolysis-according-to-tpa-administration-and-perfusion-diffusion-mismatching
#15
Yoo-Dong Won, Tae-Kyu Lee, Young-Joo Kim, Chang-Woo Chun, Do-Sung Yoo, Shin-Soo Jun
BACKGROUND: IA-Tx and advanced dynamic imaging studies have been adopted for ischemic stroke patient treatment. Many patients are treated with IV-tPA, but this treatment is not always feasible. In this study, IA-Tx was used for patients for whom IV-tPA was not indicated or when IV-tPA did not result in recanalization. METHODS: A total of 156 patients treated with IA-Tx were retrospectively reviewed. Of these, 72 patients were treated with a full dose of IV-tPA before receiving the IA-Tx; the remaining 84 patients only received IA-Tx...
March 2015: Acta Neurochirurgica
https://www.readbyqxmd.com/read/25422712/a-simple-collapse-agitation-and-pathological-crying-in-a-young-woman-atypical-onset-of-a-basilar-thrombosis
#16
Thorleif Etgen, Dragana Milankovic-Eberl, Georg Rieder
BACKGROUND: A collapse and agitation in a young person comprises many differential diagnoses, but usually does not include a life-threatening basilar thrombosis. METHODS AND RESULTS: We report the case of a 19-year old woman who presented mainly with a collapse and agitation. CT and CT-angiography yielded distal basilar thrombosis which was successfully treated by intraarterial thrombolysis. MRI confirmed multiple small ischemic lesions in the vertebrobasilar territory...
November 2014: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/25307101/intra-arterial-pulmonary-thrombolysis-at-the-postoperative-period-of-brain-aneurysm-clamping-case-report
#17
Salomón Soriano Ordinola Rojas, Viviane Cordeiro Veiga, Júlio César de Carvalho, Luis Enrique Amaya Campodônico, Fabrizio Rodrigues Assis, Sandra Patrícia Shimizu, Elaine Aparecida Morais, Roberto Buesio, Andréia Maria Marchesini, Ligia Maria Coscrato Junqueira, Carlos Vanderlei Holanda
Pulmonary thromboembolism is a major cause of morbidity and mortality of patients undergoing neurosurgical procedures. The purpose of this study was to present a case of intra-arterial pulmonary thrombolysis in recent neurosurgery postoperative period. Male patient, undergoing neurosurgery, presented as a complication on the seventh day of postoperative massive pulmonary embolism with hemodynamic instability and intraarterial pulmonary thrombolysis with alteplase was indicated. Evolution was satisfactory without bleeding complications and patient was discharged...
September 2008: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/25168332/combined-thrombolysis-in-posterior-circulation-stroke-caused-by-bilateral-vertebral-artery-dissection-in-squash-player
#18
Emilia Frankowska, Krzysztof Brzozowski, Jacek Staszewski, Norbert Kolmaga, Adam Stępień, Romana Bogusławska-Walecka
BACKGROUND AND PURPOSE: Growing number of vertebral artery dissection has been detected due to higher awareness and improved imaging techniques, even after seemingly minor head turning in young- or middle-aged adults without predisposing risk factors for cerebrovascular disease. Treatment options for this condition at this time are limited and there is a troubling shortage of controlled studies. SUMMARY OF CASE: Our patient suffered a bilateral vertebral artery dissection complicated by posterior circulation stroke...
2014: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/24871645/increased-globulin-and-its-association-with-hemorrhagic-transformation-in-patients-receiving-intra-arterial-thrombolysis-therapy
#19
Yingqi Xing, Zhen-Ni Guo, Shuo Yan, Hang Jin, Shouchun Wang, Yi Yang
Previous studies have identified a diverse set of predisposing factors for the occurrence of hemorrhagic transformation (HT), but the independent clinical predictors of HT after intraarterial thrombolysis have not been determined. In this retrospective study, we investigated the characteristics of patients with or without HT who had received intra-arterial thrombolysis therapy, using biochemical analysis, renal function test, routine blood test, blood lipid test, coagulation blood test, liver function test, random blood glucose test, time-window for intra-arterial thrombolysis, recanalization, National Institutes of Health Stroke Scale (NIHSS) score and systolic blood pressure before intra-arterial thrombolysis...
June 2014: Neuroscience Bulletin
https://www.readbyqxmd.com/read/24857945/acute-hand-ischemia-after-unintentional-intraarterial-injection-of-drugs-is-catheter-directed-thrombolysis-useful
#20
REVIEW
Romain Breguet, Sylvain Terraz, Marc Righini, Dominique Didier
Unintentional intraarterial injections are rare but may have devastating consequences. No consensus on treatment has been established owing to the wide variety of possible injected substances, incomplete understanding of the underlying pathophysiology, and the absence of case-controlled, prospective human studies. The aim of the present study and literature review was to evaluate the benefit of intraarterial thrombolysis combined with systemic anticoagulation therapy when an artery of the upper extremity is accidentally punctured and ischemia of the hand ensues...
June 2014: Journal of Vascular and Interventional Radiology: JVIR
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