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Dementia vascular complementary

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https://www.readbyqxmd.com/read/27686075/bee-venom-ameliorates-cognitive-dysfunction-caused-by-neuroinflammation-in-an-animal-model-of-vascular-dementia
#1
Mudan Cai, Jun Hwan Lee, Eun Jin Yang
Vascular dementia (VaD) is caused by the reduction of blood supply by vessel occlusion and is characterized by progressive cognitive decline. VaD incidence has been growing due to the aging population, placing greater strain on social and economic resources. However, the pathological mechanisms underlying VaD remain unclear. Many studies have used the bilateral common carotid artery occlusion (BCCAO) animal model to investigate potential therapeutics for VaD. In this study, we investigated whether bee venom (BV) improves cognitive function and reduces neuroinflammation in the hippocampus of BCCAO animals...
September 29, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27104138/differential-diagnosis-of-neurodegenerative-diseases-using-structural-mri-data
#2
Juha Koikkalainen, Hanneke Rhodius-Meester, Antti Tolonen, Frederik Barkhof, Betty Tijms, Afina W Lemstra, Tong Tong, Ricardo Guerrero, Andreas Schuh, Christian Ledig, Daniel Rueckert, Hilkka Soininen, Anne M Remes, Gunhild Waldemar, Steen Hasselbalch, Patrizia Mecocci, Wiesje van der Flier, Jyrki Lötjönen
Different neurodegenerative diseases can cause memory disorders and other cognitive impairments. The early detection and the stratification of patients according to the underlying disease are essential for an efficient approach to this healthcare challenge. This emphasizes the importance of differential diagnostics. Most studies compare patients and controls, or Alzheimer's disease with one other type of dementia. Such a bilateral comparison does not resemble clinical practice, where a clinician is faced with a number of different possible types of dementia...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/26687230/neuroprotective-effects-of-electroacupuncture-on-an-animal-model-of-bilateral-common-carotid-artery-occlusion
#3
Eun Jin Yang, MuDan Cai, Jun-Hwan Lee
Mild cognitive impairment (MCI) is considered as an intermediate zone between normal aging and dementia. The most prominent feature of MCI is an isolated mild decline in memory, whereas other cognitive functions remain intact. The symptoms of vascular cognitive impairment (VCI) range from MCI to dementia, and an animal model of VCI has been established in a gerbil by transient bilateral common carotid artery occlusion (BCCAO). In the current study, we set out to investigate whether electroacupuncture (EA) could improve memory in gerbils with BCCAO-induced MCI...
December 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/26629759/blink-reflex-may-help-discriminate-alzheimer-disease-from-vascular-dementia
#4
Fatemeh Mohammadian, Maryam Noroozian, Shahriar Nafissi, Farzad Fatehi
PURPOSE: Dementia has several different etiologies, and vascular dementia (VaD) is considered the second leading cause of dementia after Alzheimer disease (AD). Various studies used blink reflex in different spectrum of neurological diseases as a complementary diagnostic test. We performed blink test in AD, VaD, and mixed dementia to investigate different usefulness of blink reflex in differentiating these types of dementia. METHODS: Blink reflex was performed for patients with AD (n = 18), VaD (n = 17), mixed dementia (n = 19), and normal subjects (n = 20)...
December 2015: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/26443194/can-chinese-herbal-medicine-adjunctive-therapy-improve-outcomes-of-senile-vascular-dementia-systematic-review-with-meta-analysis-of-clinical-trials
#5
REVIEW
Lingfeng Zeng, Yuanping Zou, Lingshuo Kong, Ningsheng Wang, Qi Wang, Lu Wang, Ye Cao, Kezhu Wang, Yunbo Chen, Suiqing Mi, Wei Zhao, Haitao Wu, Shuyi Cheng, Weihua Xu, Weixiong Liang
Many publications have reported the growing application of complementary and alternative medicine, particularly the use of Chinese herbal medicine (CHM) in combination with routine pharmacotherapy (RP) for senile vascular dementia (SVD), but its efficacy remains largely unexplored. The purpose of this study is to evaluate the efficacy of CHM adjunctive therapy (CHMAT), which is CHM combined with RP, in the treatment of SVD. Publications in seven electronic databases were searched extensively, and 27 trials with a total of 1961 patients were included for analysis...
December 2015: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/26190980/-123-i-fp-cit-spect-imaging-in-early-diagnosis-of-dementia-in-patients-with-and-without-a-vascular-component
#6
Marina Garriga, Marta Milà, Manzoor Mir, Raid Al-Baradie, Sonia Huertas, Cesar Castejon, Laura Casas, Dolors Badenes, Nuria Giménez, M Angels Font, Jose M Gonzalez, Maria Ysamat, Miguel Aguilar, Mark Slevin, Jerzy Krupinski
Alzheimer's disease (AD) and vascular dementia (VaD) are the most common cause of dementia. Cerebral ischemia is a major risk factor for development of dementia. (123)I-FP-CIT SPECT (DaTScan) is a complementary tool in the differential diagnoses of patients with incomplete or uncertain Parkinsonism. Additional application of DaTScan enables the categorization of Parkinsonian disease with dementia (PDD), and its differentiation from pure AD, and may further contribute to change the therapeutic decision. The aim of this study was to analyze the vascular contribution towards dementia and mild cognitive impairment (MCI)...
2015: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/25790674/-treatment-of-vascular-dementia-by-chinese-herbal-medicine-a-systematic-review-of-randomized-controlled-trials-of-clinical-studies
#7
REVIEW
Wen-Jia Jian, Jing Shi, Jin-Zhou Tian, Jing-Nian Ni
OBJECTIVE: Chinese herbal medicine has been extensively used in the treatment of vascular dementia (VaD), but lacked systematic review on its efficacy and safety. So we conducted a systematic review to assess the efficacy and safety of Chinese herbal medicine in treating VaD. METHODS: CNKI, CBM, PubMed, and Wiley Online Library were retrieved for randomized trials (RCTs) on Chinese herbal medicine treating VaD patients. Randomized parallel control trials by taking Chinese herbal medicine as one treatment method and placebos/cholinesterase inhibitors/Memantine hydrochloride as the control were included...
January 2015: Chinese Journal of Integrated Traditional and Western Medicine
https://www.readbyqxmd.com/read/25598324/white-matter-lesions-and-temporal-lobe-atrophy-related-to-incidence-of-both-dementia-and-major-depression-in-70-year-olds-followed-over-10-years
#8
P Gudmundsson, P J Olesen, M Simoni, L Pantoni, S Östling, S Kern, X Guo, I Skoog
BACKGROUND AND PURPOSE: A number of studies have suggested associations between dementia and depression in older adults. One reason could be that these disorders share structural correlates, such as white matter lesions (WMLs) and cortical atrophy. No study has examined whether these lesions precede both dementia and depression independently of each other in the general population. METHODS: Whether WMLs and cortical atrophy on computed tomography predict dementia and depression was investigated in a population-based sample of 70-year-olds (n = 380) followed over 10 years...
May 2015: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/24787655/preoperative-plasma-leptin-levels-predict-delirium-in-elderly-patients-after-hip-fracture-surgery
#9
Xue-Wu Chen, Jun-Wu Shi, Ping-Shan Yang, Zhu-Qi Wu
Leptin is considered to be a modulator of the immune response. Hypoleptinemia increases the risk for Alzheimer's disease and vascular dementia. The present study aimed to investigate the ability of plasma leptin level to predict delirium in elderly patients after hip fracture surgery. Postoperative delirium (pod) was evaluated using the Confusion Assessment Method. Prolonged postoperative delirium (ppod) was defined as delirium lasting more than 4 weeks. Plasma leptin levels of 186 elderly patients and 186 elderly controls were measured by an enzyme-linked immunosorbent assay...
July 2014: Peptides
https://www.readbyqxmd.com/read/24448401/novel-pathophysiological-markers-are-revealed-by-itraq-based-quantitative-clinical-proteomics-approach-in-vascular-dementia
#10
MULTICENTER STUDY
Arnab Datta, Jingru Qian, Ruifen Chong, Raj N Kalaria, Paul Francis, Mitchell K P Lai, Christopher P Chen, Siu Kwan Sze
UNLABELLED: Vascular dementia (VaD) is a leading cause of dementia in the elderly together with Alzheimer's disease with limited treatment options. Poor understanding of the pathophysiology underlying VaD is hindering the development of new therapies. Hence, to unravel its underlying molecular pathology, an iTRAQ-2D-LC-MS/MS strategy was used for quantitative analysis of pooled lysates from Brodmann area 21 of pathologically confirmed cases of VaD and matched non-neurological controls...
March 17, 2014: Journal of Proteomics
https://www.readbyqxmd.com/read/24366243/preludes-to-brain-failure-executive-dysfunction-and-gait-disturbances
#11
Manuel Montero-Odasso, Vladimir Hachinski
The progressive and insidious gait and cognitive decline seen in older individuals without overt disease may result from a combination of age-dependent neuronal changes that are often exacerbated by vascular pathomechanisms. Emerging evidence suggests that slow gait and executive dysfunction are early phenomena in this decline and may further evolve to the development of falls and dementia. These early manifestations can be seen as "brain failure" and their co-occurrence suggests that they may share a common underlying mechanism...
April 2014: Neurological Sciences
https://www.readbyqxmd.com/read/22427648/tdp-43-and-fus-rna-binding-proteins-bind-distinct-sets-of-cytoplasmic-messenger-rnas-and-differently-regulate-their-post-transcriptional-fate-in-motoneuron-like-cells
#12
Claudia Colombrita, Elisa Onesto, Francesca Megiorni, Antonio Pizzuti, Francisco E Baralle, Emanuele Buratti, Vincenzo Silani, Antonia Ratti
The RNA-binding proteins TDP-43 and FUS form abnormal cytoplasmic aggregates in affected tissues of patients with amyotrophic lateral sclerosis and frontotemporal lobar dementia. TDP-43 and FUS localize mainly in the nucleus where they regulate pre-mRNA splicing, but they are also involved in mRNA transport, stability, and translation. To better investigate their cytoplasmic activities, we applied an RNA immunoprecipitation and chip analysis to define the mRNAs associated to TDP-43 and FUS in the cytoplasmic ribonucleoprotein complexes from motoneuronal NSC-34 cells...
May 4, 2012: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/21824429/prescribing-patterns-in-dementia-a-multicentre-observational-study-in-a-german-network-of-cam-physicians
#13
MULTICENTER STUDY
Elke Jeschke, Thomas Ostermann, Horst C Vollmar, Manuela Tabali, Friedemann Schad, Harald Matthes
BACKGROUND: Dementia is a major and increasing health problem worldwide. This study aims to investigate dementia treatment strategies among physicians specialised in complementary and alternative medicine (CAM) by analysing prescribing patterns and comparing them to current treatment guidelines in Germany. METHODS: Twenty-two primary care physicians in Germany participated in this prospective, multicentre observational study. Prescriptions and diagnoses were reported for each consecutive patient...
2011: BMC Neurology
https://www.readbyqxmd.com/read/20187760/analysis-of-clcn2-as-candidate-gene-for-megalencephalic-leukoencephalopathy-with-subcortical-cysts
#14
Gert C Scheper, Carola G M van Berkel, Lilia Leisle, Koen E de Groot, Ab Errami, Thomas J Jentsch, Marjo S Van der Knaap
Mutations in the gene MLC1 are found in approximately 80% of the patients with the inherited childhood white matter disorder megalencephalic leukoencephalopathy with subcortical cysts (MLC). Genetic linkage studies have not led to the identification of another disease gene. We questioned whether mutations in CLCN2, coding for the chloride channel protein 2 (ClC-2), are involved in MLC. Mice lacking this protein develop white matter abnormalities, which are characterized by vacuole formation in the myelin sheaths, strikingly similar to the intramyelinic vacuoles in MLC...
April 2010: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/19577379/potential-complementarity-of-high-flavanol-cocoa-powder-and-spirulina-for-health-protection
#15
Mark F McCarty, Jorge Barroso-Aranda, Francisco Contreras
Recent studies show that ingestion of flavanol-rich cocoa powder provokes increased endothelial production of nitric oxide - an effect likely mediated by epicatchin - and thus may have considerable potential for promoting vascular health. The Kuna Indians of Panama, who regularly consume large amounts of flavanol-rich cocoa, are virtually free of hypertension and stroke, even though they salt their food. Of potentially complementary merit is the cyanobacterium spirulina, which has been used as a food in certain cultures...
February 2010: Medical Hypotheses
https://www.readbyqxmd.com/read/17443563/acupuncture-for-vascular-dementia
#16
REVIEW
W N Peng, H Zhao, Z S Liu, S Wang
BACKGROUND: Dementia is a widespread condition characterized by acquired global impairment of intellect, memory and personality, but with no impairment of consciousness. There is no definitive medical or surgical treatment for vascular dementia. Acupuncture is an ancient Chinese method which has been used for both the prevention and treatment of diseases for over three thousand years. Preliminary searches revealed more than 105 studies of acupuncture for treating vascular dementia. Benefit was reported in up to 70-91% of the treatment group...
2007: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/17365248/mapping-the-connections-between-education-and-dementia
#17
Ian McDowell, Guoliang Xi, Joan Lindsay, Mary Tierney
Explanations for the association between educational attainment and the risk of dementia fall into three main categories. It may arise as an artefact of study methods; education may predict broader socioeconomic circumstances and exposures, or education may reflect brain reserve or cognitive capacity that protect against dementia. Data from the Canadian Study of Health and Aging (N=6646, giving 44,676 person-years of follow-up) are analyzed to test a series of hypotheses reflecting these explanations. Years of education showed a strong association with the risk of dementia (relative risk [RR] 2...
February 2007: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/17313960/risk-factors-for-vascular-dementia-in-elderly-psychiatric-outpatients-with-preserved-cognitive-functions
#18
Florindo Stella, Claudio E M Banzato, Elisandra Villela Gasparetto Sé, Juliana Leme Scudeler, Jaime Lisandro Pacheco, Romeu Toshiyuki Kajita
The aim of the study was to assess risk factors for vascular dementia (VaD) in elderly psychiatric outpatients without dementia, and to determine to what extent clinical interventions targeted such risk factors. Out of 250 clinical charts, 78 were selected of patients over 60 years old, who showed no signs of dementia. Information was obtained regarding demographics, clinical conditions (diagnosis according to ICD-10), complementary investigation, cognitive functions (via CAMCOG), neuroimaging, and the presence of risk factors for VaD...
June 15, 2007: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/17168239/-cognitive-impairment-classification-by-proton-magnetic-resonance-spectroscopy-and-the-contributions-of-conventional-magnetic-resonance-imaging
#19
M C Martínez-Bisbal, E Arana, L Martí-Bonmatí, B Martínez-Granados, B Celda
OBJECTIVE: To analyze the diagnostic accuracy of proton magnetic resonance spectroscopy (1H MRS) in patients with cognitive impairment and to establish the usefulness of complementary information provided by conventional magnetic resonance imaging (MRI). MATERIAL AND METHODS: 64 patients with cognitive impairment, including Alzheimer's disease (AD) (n=31), vascular dementia (n=6), mild cognitive impairment (MCI) (n=9), and major depression (n=18), were studied. All patients underwent cerebral MRI and single-volume 1H MRS using two echo times (TE, 31 and 136 ms) in the posterior cingulate gyrus and right temporal lobe...
September 2006: Radiología
https://www.readbyqxmd.com/read/16324516/-utility-of-123-i-ioflupane-spect-in-the-assessment-of-patients-with-parkinsonian-syndrome-and-cerebral-vasculopathy
#20
REVIEW
A M García Vicente, J Vaamonde Cano, A Soriano Castrejón, C Martínez Delgado, P Talavera Rubio, V M Poblete García, S Ruiz Solís, S Rodado Marina, M Cortés Romera
OBJECTIVE: To assess the utility of 123-I Ioflupane SPECT (IS) in the identification of the origin of Parkinsonism (vascular or idiopathic) in patients with cerebral vasculopathy (CV) demonstrated by morphological imaging techniques. Also, to assess the therapeutic impact. MATERIALS AND METHODS: 42 patients (16 males and 26 females) with a Parkinsonian syndrome were studied. Average age was 78.7 years (50-88). A dose of 185 MBq of 123 I-Ioflupane was injected in all subjects...
November 2005: Revista Española de Medicina Nuclear
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