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https://www.readbyqxmd.com/read/27884130/a-profile-of-the-clinical-course-of-cognition-and-comorbidity-in-mild-cognitive-impairment-and-dementia-study-the-4c-study-two-complementary-longitudinal-clinical-cohorts-in-the-netherlands
#1
Weiqi Liao, Renske E G Hamel, Marcel G M Olde Rikkert, Saskia M Oosterveld, Pauline Aalten, Frans R J Verhey, Philip Scheltens, Nicole Sistermans, Yolande A L Pijnenburg, Wiesje M van der Flier, Inez H G B Ramakers, René J F Melis
BACKGROUND: Heterogeneous disease trajectories of mild cognitive impairment (MCI) and dementia are frequently encountered in clinical practice, but there is still insufficient knowledge to understand the reasons and mechanisms causing this heterogeneity. In addition to correlates of the disorder, patient characteristics such as their health status, social environment, comorbidities and frailty may contribute to variability in trajectories over time. The current paper outlines the study design and the study population of and provides an overview of the data collected in the Clinical Course of Cognition and Comorbidity in Mild Cognitive Impairment (4C-MCI cohort, n = 315) and Dementia (4C-Dementia cohort, n = 331) Study...
November 25, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27862327/an-order-in-lewy-body-disorders-retrograde-degeneration-in-hyperbranching-axons-as-a-fundamental-structural-template-accounting-for-focal-multifocal-lewy-body-disease
#2
REVIEW
Toshiki Uchihara 内原 俊記
Initial clinical recognition of "paralysis agitans" by James Parkinson was expanded by Jean-Martin Charcot, who recognized additional clinical findings of his own, such as slowness (distinct from paralysis), rigidity (distinct from spasticity) and characteristic countenance. Charcot assembled these findings under the umbrella of "Parkinson disease (PD)". This purely clinical concept was so prescient and penetrating that subsequent neuropathological and biochemical evidences were ordered along this axis to establish the nigra-central trinity of PD (dopamine depletion, nigral lesion with Lewy bodies: LBs)...
November 14, 2016: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/27859960/cognitive-phenotypes-in-parkinson-s-disease-differ-in-terms-of-brain-network-organization-and-connectivity
#3
Renaud Lopes, Christine Delmaire, Luc Defebvre, Anja J Moonen, Annelien A Duits, Paul Hofman, Albert F G Leentjens, Kathy Dujardin
Cognitive deficits are common in Parkinson's disease and we suspect that dysfunctions of connected brain regions can be the source of these deficits. The aim of the present study was to investigate changes in whole-brain intrinsic functional connectivity according to differences in cognitive profiles in Parkinson's disease. 119 participants were enrolled and divided into four groups according to their cognitive phenotypes (determined by a cluster analysis): (i) 31 cognitively intact patients (G1), (ii) 31 patients with only slight mental slowing (G2), (iii) 43 patients with mild to moderate deficits mainly in executive functions (G3), (iv) 14 patients with severe deficits in all cognitive domains (G4-5)...
November 17, 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27817760/a-process-evaluation-of-a-psychomotor-dance-therapy-intervention-dancin-for-behavior-change-in-dementia-attitudes-and-beliefs-of-participating-residents-and-staff
#4
Azucena Guzmán, Lisa Robinson, Lynn Rochester, Ian A James, Julian C Hughes
BACKGROUND: In a previous paper, we presented results from a 12-week study of a Psychomotor DANCe Therapy INtervention (DANCIN) based on Danzón Latin Ballroom that involves motor, emotional-affective, and cognitive domains, using a multiple-baseline single-case design in three care homes. This paper reports the results of a complementary process evaluation to elicit the attitudes and beliefs of home care staff, participating residents, and family members with the aim of refining the content of DANCIN in dementia care...
November 7, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27751631/examining-the-relationship-between-multidrug-resistant-organism-acquisition-and-exposure-to-antimicrobials-in-long-term-care-populations-a-review
#5
REVIEW
Michele L Shaffer, Erika M C D'Agata, Daniel Habtemariam, Susan L Mitchell
PURPOSE: Methodological approaches to examine the association between antimicrobial exposure and multidrug-resistant organism (MDRO) acquisition are complex. This report's objectives are to review approaches used in and findings of prior studies in the long-term care setting, illustrate how these challenges were addressed in a recently completed large prospective study, and discuss strategies for future studies. METHODS: Key design and analytic approaches used in studies conducted since 2000 examining the association between antimicrobial exposure and MDRO acquisition in the long-term care setting were reviewed...
November 2016: Annals of Epidemiology
https://www.readbyqxmd.com/read/27686075/bee-venom-ameliorates-cognitive-dysfunction-caused-by-neuroinflammation-in-an-animal-model-of-vascular-dementia
#6
Mudan Cai, Jun Hwan Lee, Eun Jin Yang
Vascular dementia (VaD) is caused by the reduction of blood supply by vessel occlusion and is characterized by progressive cognitive decline. VaD incidence has been growing due to the aging population, placing greater strain on social and economic resources. However, the pathological mechanisms underlying VaD remain unclear. Many studies have used the bilateral common carotid artery occlusion (BCCAO) animal model to investigate potential therapeutics for VaD. In this study, we investigated whether bee venom (BV) improves cognitive function and reduces neuroinflammation in the hippocampus of BCCAO animals...
September 29, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27626305/depression-and-diagnosis-of-neurocognitive-impairment-in-hiv-positive-patients
#7
C A T Pinheiro, L D M Souza, J V S Motta, E F Kelbert, M S Souza, C S R Martins, F M C Coelho, K A T Pinheiro, R T Pinheiro
Neurocognitive impairment (NCI) is frequently observed in patients infected with human immunodeficiency virus (HIV) and results from the compromise of subcortical brain structures by the virus. The manifestations of NCI range from asymptomatic impairment to dementia. In addition to cognitive impairment resulting from HIV infection, other factors such as depression are associated with the loss of cognitive functions. The aim of this study was to estimate the prevalence of NCI in HIV-positive patients in a city in southern Brazil and to establish possible associations for the prevalence of NCI with HIV-related and other risk factors...
September 12, 2016: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/27583423/complementary-integrative-therapies-that-work-a-review-of-the-evidence
#8
Benjamin Kligler, Raymond Teets, Melissa Quick
Significant evidence supports the effectiveness and safety of several complementary or integrative treatment approaches to common primary care problems. Acupuncture is effective in the management of chronic low back pain. Mind-body interventions such as cognitive behavior therapy, yoga, tai chi, qi gong, and music therapy may be helpful for treating insomnia. Exercise can reduce anxiety symptoms. Herbal preparations and nutritional supplements can be useful as first-line therapy for certain conditions, such as fish oil for hypertriglyceridemia, St...
September 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/27567827/within-individual-variability-an-index-for-subtle-change-in-neurocognition-in-mild-cognitive-impairment
#9
David R Roalf, Megan Quarmley, Dawn Mechanic-Hamilton, David A Wolk, Steven E Arnold, Paul J Moberg
BACKGROUND: The transition from mild cognitive impairment (MCI) to Alzheimer's disease is characterized by a decline in cognitive performance in many domains. Cognitive performance profiles in MCI are heterogeneous, however, and additional insights into markers of incipient dementia are needed. Typically, studies focus on average or mean performance, but ignore consistency of performance across domains. WIV (within-individual variability) provides an index of this consistency and is a potential marker of cognitive decline...
August 10, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27554665/audiometric-evaluation-in-patients-with-alzheimer-s-disease
#10
Alexandre Villeneuve, Caroline Hommet, Charles Aussedat, Emmanuel Lescanne, Kevin Reffet, David Bakhos
The objective of this study is to assess the validity of ASSR as a complementary diagnostic test for peripheral hearing loss by proving a significant correlation between behavioral thresholds and ASSR. The design used in this study is monocentric prospective study from November 2014 to April 2015. The setting used in this study is the ENT-Head and Neck Surgery Department and Geriatrics Department in a French Regional and University Hospital. The participants are patients over 75 years with cognitive impairment (Alzheimer's disease or mild-cognitive impairment) with a Mini-Mental State Examination score under 27/30 and without hearing aids...
August 23, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27384985/quantitative-t2-mapping-of-white-matter-applications-for-ageing-and-cognitive-decline
#11
Michael J Knight, Bryony McCann, Demitra Tsivos, Serena Dillon, Elizabeth Coulthard, Risto A Kauppinen
In MRI, the coherence lifetime T2 is sensitive to the magnetic environment imposed by tissue microstructure and biochemistry in vivo. Here we explore the possibility that the use of T2 relaxometry may provide information complementary to that provided by diffusion tensor imaging (DTI) in ageing of healthy controls (HC), Alzheimer's disease (AD) and mild cognitive impairment (MCI). T2 and diffusion MRI metrics were quantified in HC and patients with MCI and mild AD using multi-echo MRI and DTI. We used tract-based spatial statistics (TBSS) to evaluate quantitative MRI parameters in white matter (WM)...
August 7, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27357645/fdg-pet-for-prediction-of-ad-dementia-in-mild-cognitive-impairment-a-review-of-the-state-of-the-art-with-particular-emphasis-on-the-comparison-with-other-neuroimaging-modalities-mri-and-perfusion-spect
#12
Carlos A Sánchez-Catasús, Gilles N Stormezand, Peter Jan van Laar, Peter P De Deyn, Mario Alvarez Sánchez, Rudi A J O Dierckx
This review article aims at providing a state-of-the-art review of the role of fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging (FDG-PET) in the prediction of Alzheimer's dementia in subjects suffering mild cognitive impairment (MCI), with a particular focus on the predictive power of FDG-PET compared to structural magnetic resonance imaging (sMRI). We also address perfusion single photon emission computed tomography (SPECT) as a less costly and more accessible alternative to FDG- PET. A search in PubMed was performed, taking into consideration relevant scientific articles published in English within the last five years and limited to human studies...
June 28, 2016: Current Alzheimer Research
https://www.readbyqxmd.com/read/27166586/mortality-risk-of-antipsychotic-dose-and-duration-in-nursing-home-residents-with-chronic-or-acute-indications
#13
Linda Simoni-Wastila, Yu-Jung Wei, Judith A Lucas, Nicole Brandt, Patience Moyo, Ting-Ying J Huang, Christine S Franey, Ilene Harris
OBJECTIVES: To examine disease-specific associations between antipsychotic dose and duration and all-cause mortality. DESIGN: Retrospective cohort study. SETTING: A 5% random sample of Medicare beneficiaries who had a Minimum Data Set 2.0 clinical assessment completed between 2007 and 2009. PARTICIPANTS: Three mutually exclusive cohorts of new antipsychotic users with evidence of severe mental illness (SMI, n = 5,621); dementia with behavioral symptoms (dementia + behavior) without SMI (n = 1,090); or delirium only without SMI or dementia + behavior (n = 2,100) were identified...
May 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27156075/tbk1-is-associated-with-als-and-als-ftd-in-sardinian-patients
#14
Giuseppe Borghero, Maura Pugliatti, Francesco Marrosu, Maria Giovanna Marrosu, Maria Rita Murru, Gianluca Floris, Antonino Cannas, Patrizia Occhineri, Tea B Cau, Daniela Loi, Anna Ticca, Sebastiano Traccis, Umberto Manera, Antonio Canosa, Cristina Moglia, Andrea Calvo, Marco Barberis, Maura Brunetti, J Raphael Gibbs, Alan E Renton, Edoardo Errichiello, Magdalena Zoledziewska, Antonella Mulas, Yong Qian, Jun Din, Hannah A Pliner, Bryan J Traynor, Adriano Chiò
Recently, mutations in the TANK-binding kinase 1 (TBK1) gene were identified as a cause for amyotrophic lateral sclerosis (ALS) with or without comorbid frontotemporal dementia. We have assessed the frequency and clinical characteristics of TBK1 mutations in a cohort of ALS patients of Sardinian ancestry. Whole-exome sequencing was performed on Hiseq2000 platform (Illumina). Genome analysis Toolkit was used to align and to code variants according to Human Genome (UCSC hg19). Mutation was confirmed with Sanger sequence...
July 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/27104138/differential-diagnosis-of-neurodegenerative-diseases-using-structural-mri-data
#15
Juha Koikkalainen, Hanneke Rhodius-Meester, Antti Tolonen, Frederik Barkhof, Betty Tijms, Afina W Lemstra, Tong Tong, Ricardo Guerrero, Andreas Schuh, Christian Ledig, Daniel Rueckert, Hilkka Soininen, Anne M Remes, Gunhild Waldemar, Steen Hasselbalch, Patrizia Mecocci, Wiesje van der Flier, Jyrki Lötjönen
Different neurodegenerative diseases can cause memory disorders and other cognitive impairments. The early detection and the stratification of patients according to the underlying disease are essential for an efficient approach to this healthcare challenge. This emphasizes the importance of differential diagnostics. Most studies compare patients and controls, or Alzheimer's disease with one other type of dementia. Such a bilateral comparison does not resemble clinical practice, where a clinician is faced with a number of different possible types of dementia...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27099859/breath-based-meditation-a-mechanism-to-restore-the-physiological-and-cognitive-reserves-for-optimal-human-performance
#16
Kirtigandha Salwe Carter, Robert Carter
Stress can be associated with many physiological changes resulting in significant decrements in human performance. Due to growing interests in alternative and complementary medicine by Westerners, many of the traditions and holistic yogic breathing practices today are being utilized as a measure for healthier lifestyles. These state-of-the-art practices can have a significant impact on common mental health conditions such as depression and generalized anxiety disorder. However, the potential of yogic breathing on optimizing human performance and overall well-being is not well known...
April 16, 2016: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/27076884/applications-of-text-messaging-and-bibliotherapy-for-treatment-of-patients-affected-by-depressive-symptoms
#17
Roya Taleban, Ahmadreza Zamani, Mohammad Moafi, Nasrin Jiryaee, Reza Khadivi
BACKGROUND: Intensity of depressive symptoms could be exacerbated due to the paucity of appropriate treatments. We assessed the effectiveness of bibliotherapy and text messaging, which aimed at amelioration of patient's behavior and consciousness, which could lead to suicide prevention. METHODS: This was a randomized clinical trial implemented in rural health centers of Isfahan district (Iran). Health centers were assigned in three trials consisting of the booklet, text messaging, and control groups...
2016: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/27061321/proteomics-as-an-innovative-tool-to-investigate-frontotemporal-disorders
#18
REVIEW
Anna Maria Agresta, Antonella De Palma, Anna Bardoni, Roberta Salvini, Paolo Iadarola, Pier Luigi Mauri
Neurodegenerative diseases are characterized by slow progressive loss of one or more functions of the CNS. Worldwide, the number of people affected by neurodegeneration is dramatically high and the social impact is upsetting. While being a heterogeneous group of diseases, most of these pathologies manifest similar clinical features and illness progression, thus making their diagnosis elusive. With its ability to meet the needs of neurodegenerative research, proteomics could help facilitate the diagnosis of these disorders...
April 2016: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/26996621/rational-basis-for-the-use-of-bergamot-essential-oil-in-complementary-medicine-to-treat-chronic-pain
#19
L Rombolà, D Amantea, R Russo, A Adornetto, L Berliocchi, L Tridico, M T Corasaniti, S Sakurada, T Sakurada, G Bagetta, L A Morrone
In complementary medicine, aromatherapy uses essential oils to improve agitation and aggression observed in dementia, mood, depression, anxiety and chronic pain. Preclinical research studies have reported that the essential oil obtained from bergamot (BEO) fruit (Citrus bergamia, Risso) modifies normal and pathological synaptic plasticity implicated, for instance, in nociceptive and neuropathic pain. Interestingly, recent results indicated that BEO modulates sensitive perception of pain in different models of nociceptive, inflammatory and neuropathic pain modulating endogenous systems...
2016: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/26890740/impact-of-depressive-symptoms-on-conversion-from-mild-cognitive-impairment-subtypes-to-alzheimer-s-disease-a-community-based-longitudinal-study
#20
Jiro Kida, Kiyotaka Nemoto, Chiaki Ikejima, Shogyoku Bun, Tatsuyuki Kakuma, Katsuyoshi Mizukami, Takashi Asada
BACKGROUND: While longitudinal studies have investigated the relationships between mild cognitive impairment (MCI) subtypes and dementia subtypes, the results have been contradictory. In addition, some research shows that depression accompanied by MCI might increase the risk of Alzheimer's disease (AD). OBJECTIVE: The aim of this study is to longitudinally investigate the relationships between MCI subtypes and dementia subtypes, with special attention to the effect of comorbid depressive symptoms in a Japanese rural community...
2016: Journal of Alzheimer's Disease: JAD
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