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https://www.readbyqxmd.com/read/28734065/fdg-pet-dopamine-transporter-spect-and-olfaction-combining-biomarkers-in-rem-sleep-behavior-disorder
#1
Sanne K Meles, David Vadasz, Remco J Renken, Elisabeth Sittig-Wiegand, Geert Mayer, Candan Depboylu, Kathrin Reetz, Sebastiaan Overeem, Angelique Pijpers, Fransje E Reesink, Teus van Laar, Lisette Heinen, Laura K Teune, Helmut Höffken, Marcus Luster, Karl Kesper, Sofie M Adriaanse, Jan Booij, Klaus L Leenders, Wolfgang H Oertel
BACKGROUND: Idiopathic REM sleep behavior disorder is a prodromal stage of Parkinson's disease and dementia with Lewy bodies. Hyposmia, reduced dopamine transporter binding, and expression of the brain metabolic PD-related pattern were each associated with increased risk of conversion to PD. The objective of this study was to study the relationship between the PD-related pattern, dopamine transporter binding, and olfaction in idiopathic REM sleep behavior disorder. METHODS: In this cross-sectional study, 21 idiopathic REM sleep behavior disorder subjects underwent (18) F-fluorodeoxyglucose PET, dopamine transporter imaging, and olfactory testing...
July 22, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28691506/the-effect-of-music-therapy-on-cognitive-functions-in-patients-with-dementia-a-systematic-review-and-meta-analysis
#2
Laura Fusar-Poli, Łucja Bieleninik, Natascia Brondino, Xi-Jing Chen, Christian Gold
OBJECTIVES: The aim of the present study was to meta-analyze the effect of music therapy (MT) on cognitive functions in patients with dementia. METHOD: A systematic literature search was performed in Medline, PsycINFO, Embase, CINAHL and RILM up to 8 September 2016. We included all randomized controlled trials that compared MT with standard care, or other non-musical types of intervention, evaluating cognitive outcomes in patients with dementia. Outcomes included global cognition, complex attention, executive function, learning and memory, language, and perceptual-motor skills...
July 10, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28689500/night-time-activity-forecast-by-season-and-weather-in-a-longitudinal-design-natural-light-effects-on-three-years-rest-activity-cycles-in-nursing-home-residents-with-dementia
#3
Amely Wahnschaffe, Claudia Nowozin, Andreas Rath, Theresa Floessner, Stefan Appelhoff, Mirjam Münch, Dieter Kunz
Backround: Night-time agitation is a frequent symptom of dementia. It often causes nursing home admission and has been linked to circadian rhythm disturbances. A positive influence of light interventions on night-time agitation was shown in several studies. The aim of our study was to investigate whether there is a long-term association between regional weather data (as indicator for daylight availability) and 24-hour variations of motor activity. METHODS: Motor activity of 20 elderly nursing home residents living with dementia was analyzed using recordings of continuously worn wrist activity monitors over a three-year period...
July 10, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28672181/corpus-callosum-macro-and-microstructure-in-late-life-depression
#4
Louise Emsell, Christopher Adamson, François-Laurent De Winter, Thibo Billiet, Daan Christiaens, Filip Bouckaert, Katarzyna Adamczuk, Rik Vandenberghe, Marc L Seal, Pascal Sienaert, Stefan Sunaert, Mathieu Vandenbulcke
BACKGROUND: Differences in corpus callosum (CC) morphology and microstructure have been implicated in late-life depression and may distinguish between late and early-onset forms of the illness. However, a multimodal approach using complementary imaging techniques is required to disentangle microstructural alterations from macrostructural partial volume effects. METHODS: 107 older adults were assessed: 55 currently-depressed patients without dementia and 52 controls without cognitive impairment...
November 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28671117/a-cross-validation-of-fdg-and-amyloid-pet-biomarkers-in-mild-cognitive-impairment-for-the-risk-prediction-to-dementia-due-to-alzheimer-s-disease-in-a-clinical-setting
#5
Leonardo Iaccarino, Konstantinos Chiotis, Pierpaolo Alongi, Ove Almkvist, Anders Wall, Chiara Cerami, Valentino Bettinardi, Luigi Gianolli, Agneta Nordberg, Daniela Perani
Assessments of brain glucose metabolism (18F-FDG-PET) and cerebral amyloid burden (11C-PiB-PET) in mild cognitive impairment (MCI) have shown highly variable performances when adopted to predict progression to dementia due to Alzheimer's disease (ADD). This study investigates, in a clinical setting, the separate and combined values of 18F-FDG-PET and 11C-PiB-PET in ADD conversion prediction with optimized data analysis procedures. Respectively, we investigate the accuracy of an optimized SPM analysis for 18F-FDG-PET and of standardized uptake value ratio semiquantification for 11C-PiB-PET in predicting ADD conversion in 30 MCI subjects (age 63...
June 24, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28641164/protective-effects-of-flavonoids-against-alzheimer-s-disease-related-neural-dysfunctions
#6
REVIEW
Mahsa Bakhtiari, Yunes Panahi, Javad Ameli, Behrad Darvishi
Senile ages of human life is mostly associated with developmental of several neurological complicated conditions including decreased cognition and reasoning, increased memory loss and impaired language performance. Alzheimer's disease (AD) is the most prevalent neural disorder associated with dementia, consisting of about 70% of dementia reported cases. Failure of currently approved chemical anti-AD therapeutic agents has once again brought up the idea of administering naturally occurring compounds as effective alternative and/or complementary regimens in AD treatment...
June 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28620158/clinical-features-and-sleep-analysis-of-chinese-patients-with-fatal-familial-insomnia
#7
Liyong Wu, Hui Lu, Xianling Wang, Jia Liu, Chaoyang Huang, Jing Ye, Cuijiang Li, Jun Lu, Yuping Wang, Jianping Jia, Shuqin Zhan
This study aimed to examine clinical features, sleep, abnormal sleep-wake transition and non-sleep disturbances as well as lab tests in Chinese fatal familial insomnia (FFI) subjects. Patients with confirmed clinical and laboratory diagnosis of FFI have been retrospectively reviewed. The clinical features and the results of the complementary tests, including polysomnography (PSG), brain imaging and genetic analysis, were used. Two male and three female patients were recruited in this study. Three of the five patients had more comprehensive family medical records...
June 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28559865/effects-of-music-on-agitation-in-dementia-a-meta-analysis
#8
REVIEW
Siv K A Pedersen, Per N Andersen, Ricardo G Lugo, Marita Andreassen, Stefan Sütterlin
Agitation is a common problem in patients suffering from dementia and encompasses a variety of behaviors such as repetitive acts, restlessness, wandering, and aggressive behaviors. Agitation reduces the probability of positive social interaction and increases the psychological and organizational burden. While medical interventions are common, there is need for complementary or alternative methods. Music intervention has been brought forward as a promising method to reduce agitation in dementia. While interventions, target groups and research designs differ, there has so far not been a systematic overview assessing the effect of music intervention for agitation in patients with dementia...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28501231/complementary-and-integrative-interventions-for-chronic-neurologic-conditions-encountered-in-the-primary-care-office
#9
REVIEW
Danny Bega
Chronic neurologic conditions are frequently managed in the primary care setting, and patients with these conditions are increasingly seeking nonconventional treatment options. This article provides a review and summary of the evidence for some of the most commonly studied and most frequently used complementary and integrative interventions for 3 conditions managed every day in primary care offices - diabetic neuropathy, migraine, and dementia.
June 2017: Primary Care
https://www.readbyqxmd.com/read/28474568/lipid-biomarkers-in-alzheimer-s-disease
#10
Amira Zarrouk, Meryam Debbabi, Maryem Bezine, El Mostafa Karym, Asmaa Badreddine, Olivier Rouaud, Thibault Moreau, Mustapha Cherkaoui-Malki, Mohamed El Ayeb, Boubker Nasser, Mohamed Hammami, Gérard Lizard
Alzheimer's disease (AD) is the most frequent form of dementia. It is characterized by three successive stages (preclinical, mild cognitive impairment (MCI), and dementia), which are determined with a panel of complementary tests including behavioral and biochemical tests and imaging methods. Currently accepted biomarkers of AD include levels of brain chemicals related to amyloid or tau, and imaging-derived estimates of the size and metabolic activity of specific brain regions. At the moment, the pathogenesis of AD is still poorly understood but some studies support a link between lipid metabolism disorders and AD...
May 4, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28356117/association-of-traditional-chinese-medicine-therapy-and-the-risk-of-dementia-in-patients-with-hypertension-a-nationwide-population-based-cohort-study
#11
Kuen-Hau Chen, Ming-Hsien Yeh, Hanoch Livneh, Bor-Chyuan Chen, I-Hsin Lin, Ming-Chi Lu, Tzung-Yi Tsai, Chia-Chou Yeh
BACKGROUND: Patients with hypertension (HTN) reportedly have a higher risk of developing dementia. However, it remains unclear if use of Traditional Chinese Medicine (TCM), the most common form of complementary and alternative medicine, can help lower the risk of dementia for these patients. So the aim of the study was to investigate the effects of TCM on dementia risk among patients with hypertension. METHODS: This longitudinal cohort study used the Taiwanese National Health Insurance Research Database (NHIRD) to identify 143,382 newly diagnosed hypertension patients aged 20-90 years who received treatment between 1998 and 2007...
March 29, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28303161/a-systematic-review-of-intervention-studies-examining-nutritional-and-herbal-therapies-for-mild-cognitive-impairment-and-dementia-using-neuroimaging-methods-study-characteristics-and-intervention-efficacy
#12
REVIEW
Genevieve Z Steiner, Danielle C Mathersul, Freya MacMillan, David A Camfield, Nerida L Klupp, Sai W Seto, Yong Huang, Mark I Hohenberg, Dennis H Chang
Neuroimaging facilitates the assessment of complementary medicines (CMs) by providing a noninvasive insight into their mechanisms of action in the human brain. This is important for identifying the potential treatment options for target disease cohorts with complex pathophysiologies. The aim of this systematic review was to evaluate study characteristics, intervention efficacy, and the structural and functional neuroimaging methods used in research assessing nutritional and herbal medicines for mild cognitive impairment (MCI) and dementia...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28270784/auditory-and-non-auditory-contributions-for-unaided-speech-recognition-in-noise-as-a-function-of-hearing-aid-use
#13
Anja Gieseler, Maike A S Tahden, Christiane M Thiel, Kirsten C Wagener, Markus Meis, Hans Colonius
Differences in understanding speech in noise among hearing-impaired individuals cannot be explained entirely by hearing thresholds alone, suggesting the contribution of other factors beyond standard auditory ones as derived from the audiogram. This paper reports two analyses addressing individual differences in the explanation of unaided speech-in-noise performance among n = 438 elderly hearing-impaired listeners (mean = 71.1 ± 5.8 years). The main analysis was designed to identify clinically relevant auditory and non-auditory measures for speech-in-noise prediction using auditory (audiogram, categorical loudness scaling) and cognitive tests (verbal-intelligence test, screening test of dementia), as well as questionnaires assessing various self-reported measures (health status, socio-economic status, and subjective hearing problems)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28249715/sleep-and-hippocampal-neurogenesis-implications-for-alzheimer-s-disease
#14
REVIEW
Brianne A Kent, Ralph E Mistlberger
Alzheimer's disease (AD) is the most common cause of dementia and currently there are no effective disease-modifying treatments available. Hallmark symptoms of AD include impaired hippocampus-dependent episodic memory and disrupted sleep and circadian rhythms. The pathways connecting these symptoms are of particular interest because it is well established that sleep and circadian disruption can impair hippocampus-dependent learning and memory. In rodents, these procedures also markedly suppress adult hippocampal neurogenesis, a form of brain plasticity that is believed to play an important role in pattern separation, and thus episodic memory...
April 2017: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/28239906/complementary-medicine-for-treatment-of-agitation-and-delirium-in-older-persons-a-systematic-review-and-narrative-synthesis
#15
REVIEW
Ilana Levy, Samuel Attias, Eran Ben-Arye, Boaz Bloch, Elad Schiff
BACKGROUND: Agitation and delirium frequently occur in cognitively impaired older people. We conducted a systematic review with narrative synthesis of the literature aiming to assess effectiveness of complementary and alternative medicine (CAM) modalities to address these conditions. METHODS: Following preliminary search, we included 40 original researches on CAM treatment of delirium and agitation in older persons. Then, the quality of these studies was assessed using the Downs and Black Checklist and Quality Assessment Tool for Studies with Diverse Designs, and the effect sizes were calculated...
May 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28091722/hyperphosphorylated-tau-causes-reduced-hippocampal-ca1-excitability-by-relocating-the-axon-initial-segment
#16
Robert John Hatch, Yan Wei, Di Xia, Jürgen Götz
Hyperphosphorylated tau has a critical role in tauopathies such as Alzheimer's disease and frontotemporal dementia, impairing neuronal function and eventually leading to neurodegeneration. A critical role for tau is supported by studies in transgenic mouse models that express the P301L tau mutation found in cases of familial frontotemporal dementia, with the accumulation of hyperphosphorylated tau in the hippocampus causing reductions in hippocampal long-term potentiation and impairments in spatial learning and memory...
May 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28078993/mirnas-new-biomarkers-and-therapeutic-targets-in-dementia
#17
Ana Teresa de Barros Viegas, Joana Ribeiro Guedes, Ana Rafaela Oliveira, Ana Maria Sequeira Cardoso, Ana Luisa Colaco Cardoso
BACKGROUND: Dementia is a complex pathological state that affects millions of individuals worldwide and is responsible for a huge socioeconomic burden, making it a major health concern of current times. Given the impact of dementia in both patients and caregivers, it is crucial to fully clarify the molecular mechanisms underlying dementia-associated disorders, since without this knowledge our ability to correctly diagnose and treat these diseases is severely hampered. METHODS: Epigenetic mechanisms, such as miRNA-mediated post-transcriptional regulation, have been reported to play a role in dementia pathogenesis...
2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28062720/multimodal-characterization-of-older-apoe2-carriers-reveals-selective-reduction-of-amyloid-load
#18
Michel J Grothe, Sylvia Villeneuve, Martin Dyrba, David Bartrés-Faz, Miranka Wirth
OBJECTIVE: To comprehensively assess neurobiological effects of the protective APOE2 allele in the aged brain using a cross-sectional multimodal neuroimaging approach. METHODS: Multimodal neuroimaging data were obtained from a total of 572 older individuals without dementia (cognitively normal and mild cognitive impairment) enrolled in the Alzheimer's Disease Neuroimaging Initiative and included assessments of regional amyloid load with AV45-PET, glucose metabolism with fluorodeoxyglucose-PET, and gray matter volume with structural MRI...
February 7, 2017: Neurology
https://www.readbyqxmd.com/read/28057562/imaging-retina-to-study-dementia-and-stroke
#19
REVIEW
Carol Yim-Lui Cheung, M Kamran Ikram, Christopher Chen, Tien Yin Wong
With increase in life expectancy, the number of persons suffering from common age-related brain diseases, including neurodegenerative (e.g., dementia) and cerebrovascular (e.g., stroke) disease is expected to rise substantially. As current neuro-imaging modalities such as magnetic resonance imaging may not be able to detect subtle subclinical changes (resolution <100-500 μm) in dementia and stroke, there is an urgent need for other complementary techniques to probe the pathophysiology of these diseases...
March 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28034725/mechanisms-of-acupuncture-on-vascular-dementia-a-review-of-animal-studies
#20
Yang Ye, Wen Zhu, Xue-Rui Wang, Jing-Wen Yang, Ling-Yong Xiao, Yi Liu, Xin Zhang, Cun-Zhi Liu
Vascular dementia (VaD) is the second leading type of dementia after Alzheimer's disease plaguing the aging population. Acupuncture has served as alternative and complementary medicine in the world for a long time and its use for VaD is based on a large body of preclinical and clinical researches. The mechanisms that underlie the protective effects of acupuncture are slowly beginning to be understood. Acupuncture influences multiple aspects of the pathological process of VaD. It improves cognitive function through protecting cerebral neurons from oxidative stress, apoptosis, and neuroinflammation, regulating glucose metabolism and neurotransmitters...
July 2017: Neurochemistry International
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