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RANDOMIZED CONTROLLED TRIAL
Claudia Cooper, Sedigheh Zabihi, Amirah Akhtar, Teresa Lee, Abdinasir Isaaq, Marie Le Novere, Julie Barber, Kathryn Lord, Penny Rapaport, Sara Banks, Sandra Duggan, Margaret Ogden, Kate Walters, Vasiliki Orgeta, Kenneth Rockwood, Laurie T Butler, Jill Manthorpe, Briony Dow, Juanita Hoe, Rachael Hunter, Sube Banerjee, Jessica Budgett, Larisa Duffy
INTRODUCTION: In the first randomised controlled trial of a dementia training and support intervention in UK homecare agencies, we aimed to assess: acceptability of our co-designed, manualised training, delivered by non-clinical facilitators; outcome completion feasibility; and costs for a future trial. METHODS: This cluster-randomised (2:1) single-blind, feasibility trial involved English homecare agencies. Intervention arm agency staff were offered group videocall sessions: 6 over 3 months, then monthly for 3 months (NIDUS-professional)...
April 1, 2024: Age and Ageing
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JOURNAL ARTICLE
Nootchanat Mairuae, Nut Palachai, Parinya Noisa
The incidence of dementia is rising, with neuronal cell death from oxidative stress and apoptosis recognized as a significant contributor to its development. However, effective strategies to combat this condition are lacking, necessitating further investigation. This study aimed to assess the potential of an anthocyanin-rich extract from Zea mays L. var. ceratina (AZC) in alleviating neuronal cell death.Neurotoxicity was induced in SH-SY5Y cells using hydrogen peroxide (H2 O2 ) at a concentration of 200 µM...
April 17, 2024: BMC complementary medicine and therapies
#3
JOURNAL ARTICLE
Isidro Ferrer
Golgi methods were used to study human neuropathology in the 1970s, 1980s, and 1990s of the last century. Although a relatively small number of laboratories applied these methods, their impact was crucial by increasing knowledge about: (1) the morphology, orientation, and localization of neurons in human cerebral and cerebellar malformations and ganglionic tumors, and (2) the presence of abnormal structures including large and thin spines (spine dysgenesis) in several disorders linked to mental retardation, focal enlargements of the axon hillock and dendrites (meganeurites) in neuronal storage diseases, growth cone-like appendages in Alzheimer disease, as well as abnormal structures in other dementias...
April 15, 2024: Journal of Neuropathology and Experimental Neurology
#4
JOURNAL ARTICLE
Yingying Yang, Wenya Chen, Zhenmei Lin, Yijing Wu, Yuqing Li, Xing Xia
BACKGROUND: Mitochondrial dysfunction is one of the distinctive features of neurons in patients with Alzheimer's disease (AD). Intraneuronal autophagosomes selectively phagocytose and degrade the damaged mitochondria, mitigating neuronal damage in AD. Panax notoginseng saponins (PNS) can effectively reduce oxidative stress and mitochondrial damage in the brain of animals with AD, but their exact mechanism of action is unknown. METHODS: Senescence-accelerated mouse prone 8 (SAMP8) mice with age-related AD were treated with PNS for 8 weeks...
April 4, 2024: BMC complementary medicine and therapies
#5
Elaheh Zendehrouh, Mohammad S E Sendi, Anees Abrol, Ishaan Batta, Reihaneh Hassanzadeh, Vince D Calhoun
Alzheimer's disease (AD) is the most common form of age-related dementia, leading to a decline in memory, reasoning, and social skills. While numerous studies have investigated the genetic risk factors associated with AD, less attention has been given to identifying a brain imaging-based measure of AD risk. This study introduces a novel approach to assess mild cognitive impairment MCI, as a stage before AD, risk using neuroimaging data, referred to as a brain-wide risk score (BRS), which incorporates multimodal brain imaging...
March 14, 2024: medRxiv
#6
JOURNAL ARTICLE
Adam M Staffaroni, Annie L Clark, Jack C Taylor, Hilary W Heuer, Mark Sanderson-Cimino, Amy B Wise, Sreya Dhanam, Yann Cobigo, Amy Wolf, Masood Manoochehri, Leah Forsberg, Carly Mester, Katherine P Rankin, Brian S Appleby, Ece Bayram, Andrea Bozoki, David Clark, R Ryan Darby, Kimiko Domoto-Reilly, Julie A Fields, Douglas Galasko, Daniel Geschwind, Nupur Ghoshal, Neill Graff-Radford, Murray Grossman, Ging-Yuek Hsiung, Edward D Huey, David T Jones, Maria I Lapid, Irene Litvan, Joseph C Masdeu, Lauren Massimo, Mario F Mendez, Toji Miyagawa, Belen Pascual, Peter Pressman, Vijay K Ramanan, Eliana Marisa Ramos, Katya Rascovsky, Erik D Roberson, M Carmela Tartaglia, Bonnie Wong, Bruce L Miller, John Kornak, Walter Kremers, Jason Hassenstab, Joel H Kramer, Bradley F Boeve, Howard J Rosen, Adam L Boxer
IMPORTANCE: Frontotemporal lobar degeneration (FTLD) is relatively rare, behavioral and motor symptoms increase travel burden, and standard neuropsychological tests are not sensitive to early-stage disease. Remote smartphone-based cognitive assessments could mitigate these barriers to trial recruitment and success, but no such tools are validated for FTLD. OBJECTIVE: To evaluate the reliability and validity of smartphone-based cognitive measures for remote FTLD evaluations...
April 1, 2024: JAMA Network Open
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JOURNAL ARTICLE
Maryam Delfan, Parastou Kordestani-Moghaddam, Mohammad Gholami, Khadije Kazemi, Rasool Mohammadi
INTRODUCTION: Mild cognitive impairment is the middle level of natural cognitive impairment during primary steps of dementia. There are a few studies about improving the cognitive performance and sleep quality in patients with a limited dementia. So, this study was conducted to evaluate the effects of Bacopa monnieri on cognitive performance and sleep quality of patients with mild cognitive impairment. MATERIALS AND METHODS: In this study, 62 patients with mild cognitive impairment were categorized into two groups of control and intervention...
March 3, 2024: Explore: the Journal of Science and Healing
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REVIEW
Miwa Ishihara, Sanae Matsunaga, Rubana Islam, Ogusa Shibata, Ung-Il Chung
Dementia is highly prevalent in Japan, a super-aged society where almost a third of the population is above 65 years old. Japan has been implementing ageing and dementia policies since 2000 and now has a wealth of experience to share with other nations who are anticipating a similar future regarding dementia. This article focuses on the 2019 National Framework for Promotion of Dementia Policies that, based on its philosophy of Inclusion and Risk Reduction, lays out five complementary strategies. Together, these five strategies encourage a whole of society approach in dementia care...
February 29, 2024: Global health & medicine
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JOURNAL ARTICLE
Fei Li, Fengxia Hu, Yi Liang, Fen Liang, Huiqun Tan, Sisi Xing
CONTEXT: Severe cases of stroke can lead to cognitive impairment or even dementia. The most critical factor related to cognitive impairment after strokes is patients' lack of understanding about or attention to their conditions. Strengthening standardized management post-stroke has become a common goal for clinical workers and patients. OBJECTIVE: The study intended to explore, during post-discharge follow-up, the effectiveness of standardized management of patients with post-stroke cognitive impairment, which could provide guidance for patients and doctors to improve patients' follow-up plans...
March 1, 2024: Alternative Therapies in Health and Medicine
#10
Eleonora Rossi, Francesco Marrosu, Luca Saba
BACKGROUND: Alzheimer's disease (AD) is a complex condition that affects various aspects of a patient's life. Music therapy may be considered a beneficial supplementary tool to traditional therapies, that not fully address the range of AD manifestations. OBJECTIVE: The purpose of this systematic review is to investigate whether music therapy can have a positive impact on AD patients and on which symptoms. METHODS: The main research databases employed have been PubMed and Cochrane, using the keywords "dementia", "music therapy", "Alzheimer", "fMRI", "music", and "EEG"...
February 26, 2024: Journal of Alzheimer's Disease: JAD
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JOURNAL ARTICLE
Hongmin Wang, Xin Zhang, Peizhi Wang, Guining Dai, Li Liu, Yanfang Xu, Huijun Wang, Yongqian Zhang
OBJECTIVE: To investigate the effects of electronic biofeedback combined with nursing intervention and conventional drug treatment on cognitive function in patients with vascular cognitive impairment-no dementia (VCIND). METHODS: A total of 102 patients with VCIND treated in the Department of Neurology from January 2021 to May 2022 were enrolled and divided into the routine treatment group and biofeedback group according to different treatment methods. The routine treatment group was given conventional drug therapy and nursing intervention; for the biofeedback group, electronic biofeedback therapy was added, based on the routine treatment group...
January 29, 2024: Acta Neurologica Belgica
#12
JOURNAL ARTICLE
Elena Tsoy, Renaud La Joie, Lawren VandeVrede, Julio C Rojas, Claire Yballa, Brandon Chan, Argentina Lario Lago, Anne-Marie Rodriguez, Collette A Goode, Sabrina J Erlhoff, Boon Lead Tee, Charles Windon, Serggio Lanata, Joel H Kramer, Bruce L Miller, Peggye Dilworth-Anderson, Adam L Boxer, Gil D Rabinovici, Katherine L Possin
INTRODUCTION: With emergence of disease-modifying therapies, efficient diagnostic pathways are critically needed to identify treatment candidates, evaluate disease severity, and support prognosis. A combination of plasma biomarkers and brief digital cognitive assessments could provide a scalable alternative to current diagnostic work-up. METHODS: We examined the accuracy of plasma biomarkers and a 10-minute supervised tablet-based cognitive assessment (Tablet-based Cognitive Assessment Tool Brain Health Assessment [TabCAT-BHA]) in predicting amyloid β positive (Aβ+) status on positron emission tomography (PET), concurrent disease severity, and functional decline in 309 older adults with subjective cognitive impairment (n = 49), mild cognitive impairment (n = 159), and dementia (n = 101)...
January 15, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#13
Yoko Hirata, Hideyuki Hoshi, Momoko Kobayashi, Keita Shibamiya, Keisuke Fukasawa, Sayuri Ichikawa, Yoshihito Shigihara
KEY CLINICAL MESSAGE: Cognitive impairment associated dementia is treatable non-pharmacologically. Monitoring tools are important to provide proper treatment. The present study showed that the resting-state brain activity measured using magnetoencephalography reflects their outcomes and captures clinical impressions better than neuropsychological assessments, which have inherent limitations such as the practice effect. ABSTRACT: Mild cognitive impairment (MCI) is a prodromal phase of dementia caused by brain diseases...
January 2024: Clinical Case Reports
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JOURNAL ARTICLE
Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia.
Lyubka Tancheva, Reni Kalfin, Borislav Minchev, Diamara Uzunova, Krasimira Tasheva, Elina Tsvetanova, Almira Georgieva, Albena Alexandrova, Miroslava Stefanova, Ayten Solak, Maria Lazarova, Yordan Hodzhev, Valya Grigorova, Dobri Yarkov, Polina Petkova-Kirova
Alzheimer's disease manifests as a complex pathological condition, with neuroinflammation, oxidative stress and cholinergic dysfunction being a few of the many pathological changes. Due to the complexity of the disease, current therapeutic strategies aim at a multitargeted approach, often relying on a combination of substances with versatile and complementary effects. In the present study, a unique combination of α-lipoic acid, citicoline, extracts of leaves from olive tree and green tea, vitamin D3, selenium and an immune-supporting complex was tested in scopolamine-induced dementia in rats...
November 28, 2023: Antioxidants (Basel, Switzerland)
#15
REVIEW
Jorge Buele, José Luis Varela-Aldás, Guillermo Palacios-Navarro
BACKGROUND: In recent years, the use of virtual reality (VR) as a complementary intervention in treating cognitive impairment has significantly increased. VR applications based on instrumental activities of daily living (iADL-VR) could offer a promising approach with greater ecological validity for intervention in groups with cognitive impairments. However, the effectiveness of this approach is still debated. OBJECTIVE: This systematic review aims to synthesize the effects of iADL-VR interventions to rehabilitate, train, or stimulate cognitive functions in healthy adults and people with mild cognitive impairment (MCI) and different types of dementia...
December 19, 2023: Journal of Neuroengineering and Rehabilitation
#16
JOURNAL ARTICLE
Hou-Hsun Liao, Hanoch Livneh, Hua-Lung Huang, Jui-Yu Hung, Ming-Chi Lu, How-Ran Guo, Tzung-Yi Tsai
BACKGROUND: Dementia is a prevalent condition in type 2 diabetes mellitus (T2DM) patients. While Chinese herbal medicine (CHM) is often employed as complementary therapy for glycemic control, its effect in controlling likelihood of dementia has not yet been fully elucidated. AIM: To compare the risk of dementia between T2DM patients with and without CHM treatment. METHODS: We undertook a nested case-control study and obtained data on patients 20-70 years of age who received medical care for T2DM between 2001 and 2010 from the National Health Insurance Research database in Taiwan...
November 15, 2023: World Journal of Diabetes
#17
REVIEW
Sarah A Nguyen, Hanadi Ajam Oughli, Helen Lavretsky
Integrative medicine takes a holistic approach because it considers multiple aspects of the individual. This includes a person's physical, emotional, interpersonal, behavioral, nutritional, environmental, and spiritual dimensions of wellbeing that contribute to the Whole Person Health. There is increasing interest and popularity of integrative approaches to treating cognitive decline and dementia because of the multifactorial nature of aging and the limited pharmacological interventions available in treating cognitive decline and dementia, particularly Alzheimer's disease, the most common type of dementia...
December 7, 2023: Journal of Alzheimer's Disease: JAD
#18
JOURNAL ARTICLE
Chia-Lin Lin, Andy Chern, Ming-Jen Wang, Shun-Ku Lin
OBJECTIVE: Acupuncture, a widely employed traditional therapeutic modality known for its efficacy in pain alleviation and diverse condition management, may inadvertently result in mechanical nerve injury due to its invasive nature. This research aimed to ascertain the incidence of nerve injuries post-acupuncture, identify associated risk factors, and map the distribution of nerve injury sites. METHODS: A case-control study nested in the National Health Insurance Research Database (NHIRD) 2000-2018 two million cohort was conducted...
November 29, 2023: Complementary Therapies in Medicine
#19
JOURNAL ARTICLE
Nathan N Kim, Charissa Tan, Enze Ma, Selin Kutlu, Enrique Carrazana, Vajjhala Vimala, Jason Viereck, Kore Liow
INTRODUCTION: Currently, there are limited accessible and cost-effective biomarkers for preclinical Alzheimer's disease (AD) patients. However, the apolipoprotein E (ApoE) polymorphic alleles can predict if someone is at high (e4), neutral (e3), or low (e2) genetic risk for developing AD. This study analyzed electroencephalogram (EEG) reports from individuals with various ApoE genotypes, aiming to identify EEG changes and patterns that could potentially serve as predictive markers for preclinical AD progression...
October 2023: Curēus
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JOURNAL ARTICLE
Adriana Żyła, Anne Martel, Przemysław Jurczak, Augustyn Moliński, Aneta Szymańska, Maciej Kozak
Neurodegenerative diseases, such as Alzheimer's disease (AD) and various types of amyloidosis, are incurable; therefore, understanding the mechanisms of amyloid decomposition is crucial to develop an effective drug against them for future therapies. It has been reported that one out of three people over the age of 85 are suffering from dementia as a comorbidity to AD. Amyloid beta (Aβ), the hallmark of AD, transforms structurally from monomers into β-stranded aggregates (fibrils) via multiple oligomeric states...
November 27, 2023: Scientific Reports
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