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high doses ibuprofen

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https://www.readbyqxmd.com/read/29105796/penetration-and-pharmacokinetics-of-non-steroidal-anti-inflammatory-drugs-in-rat-prostate-tissue
#1
Venkata K Yellepeddi, Jayashree Radhakrishnan, Rajan Radhakrishnan
BACKGROUND: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) involves inflammation of the prostate and affects the quality of life of men of all ages. It is well reported in clinical studies that the treatment for CP/CPPS using nonsteroidal anti-inflammatory drugs (NSAIDs) produced favorable outcomes. However, currently, there are no guidelines on choice of the NSAIDs for the treatment of CP/CPPS. Therefore, in the current research study, we evaluated the prostate tissue penetration of four NSAIDs in rats to provide guidance on choice of NSAIDs for the treatment of CP/CPPS...
November 6, 2017: Prostate
https://www.readbyqxmd.com/read/29071151/silodosin-in-the-treatment-of-distal-ureteric-stones-in-children-a-prospective-randomised-placebo-controlled-study
#2
Hazem Elgalaly, Ahmed Eliwa, Mohamed Seleem, Emad Salem, Mohammed Omran, Haitham Shello, Khalid Abdelwahab, Salem Khalil, Mostafa Kamel
OBJECTIVES: To evaluate the possible role of silodosin (a highly selective α1A-adrenoceptor antagonist) in facilitating the passage of distal ureteric stones (DUS) in children, as the role of α-blockers as medical expulsive therapy is well known in adults. PATIENTS AND METHODS: In all, 40 paediatric patients (27 boys and 13 girls) diagnosed with unilateral, single, radiopaque DUS of <10 mm were included in the study. Their mean (SD, range) age was 8.1 (2.7, 5-17) years...
September 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29038738/a-case-of-infective-endocarditis-and-spinal-epidural-abscess-caused-by-streptococcus-mitis-bacteremia
#3
Victoria S Byrd, Attila S Nemeth
A 57-year-old man presented with abdominal pain, hematemesis, and melena. He reported taking high-dose ibuprofen for back pain and drinking several 24-ounce beers daily. Examination was remarkable for icteric sclera, poor dentition, tachycardia, and crescendo-decrescendo murmur at right upper sternal border, radiating to the carotids. Labs revealed leukocytosis, anemia, thrombocytopenia, and elevated liver function tests and INR. Endoscopy demonstrated antral ulcers, duodenitis, and esophagitis. Blood cultures were obtained and broad-spectrum antibiotics started; cultures later grew Streptococcus mitis, and antibiotic coverage was narrowed...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29026363/highly-accelerated-onset-of-hydroxychloroquine-macular-retinopathy
#4
Ethan M Stern, Jordan S Johnson, Donald A Mazzulla
BACKGROUND: Hydroxychloroquine (HCQ, Plaquenil) is often prescribed in lieu of other sulfate antimalarials to treat rheumatologic diseases because of its pharmacologic efficacy and few reported side effects. However, a known potential side effect of HCQ is retinal toxicity. CASE REPORT: A 61-year-old black female presented for screening of ophthalmic disease 2 months after initiation of HCQ for the treatment of polyarthralgia with a positive rheumatoid factor. At the time of the examination, she had taken a cumulative total of 19...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29022772/formulation-and-delivery-strategies-of-ibuprofen-challenges-and-opportunities
#5
Jake Irvine, Afrina Afrose, Nazrul Islam
Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID) is mostly administered orally and topically to relieve acute pain and fever. Due to its mode of action this drug may be useful in the treatment regimens of other, more chronic conditions, like cystic fibrosis. This drug is poorly soluble in aqueous media and thus the rate of dissolution from the currently available solid dosage forms is limited. This leads to poor bioavailability at high doses after oral administration, thereby increasing the risk of unwanted adverse effects...
October 12, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28991796/continuous-transformation-of-chiral-pharmaceuticals-in-enzymatic-membrane-bioreactors-for-advanced-wastewater-treatment
#6
Luong N Nguyen, Faisal I Hai, James A McDonald, Stuart J Khan, William E Price, Long D Nghiem
This study demonstrates continuous enantiomeric inversion and further biotransformation of chiral profens including ibuprofen, naproxen and ketoprofen by an enzymatic membrane bioreactor (EMBR) dosed with laccase. The EMBR showed non-enantioselective transformations, with high and consistent transformation of both (R)- and (S)-ibuprofen (93 ± 6%, n = 10), but lower removals of both enantiomers of naproxen (46 ± 16%, n = 10) and ketoprofen (48 ± 17%, n = 10). Enantiomeric analysis revealed a bidirectional but uneven inversion of the profens, for example 14% inversion of (R)- to (S)- compared to 4% from (S)- to (R)-naproxen...
October 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28983670/analgesia-mis-usage-on-a-dental-emergency-service-a-patient-survey
#7
Geert Hommez, B Ongena, R G E C Cauwels, P De Paepe, V Christiaens, W Jacquet
OBJECTIVES: Analgesics are one of the most frequently used medicines. Self-medication and misuse have been described in the literature. The purpose of this study was to document analgesic (mis)use in a population seeking emergency dental treatment. MATERIAL AND METHODS: Patients consulting a dental emergency service were randomly asked to complete a questionnaire on analgesic use, knowledge and information on the analgesics and on their pain history. A photobook was used as an aid to identify products used...
October 5, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28962074/study-of-pharmaceuticals-in-surface-and-wastewater-from-cuernavaca-morelos-mexico-occurrence-and-environmental-risk-assessment
#8
José Abraham Rivera-Jaimes, Cristina Postigo, Rosa María Melgoza-Alemán, Jaume Aceña, Damia Barceló, Miren López de Alda
The present work describes the first known study to date on the occurrence of pharmaceuticals in surface water and wastewater of Cuernavaca, the capital of the state of Morelos (México). Selected pharmaceuticals (a total of 35) were extracted from the collected water samples with a generic solid phase extraction (SPE) protocol and determined in the sample extracts by means of high-performance liquid chromatography coupled to electrospray ionization-tandem mass spectrometry (HPLC-ESI-MS/MS). A screening level risk assessment combining the measured environmental concentrations (MECs) with dose-response data based on predicted no-effect concentrations (PNECs) was also applied to estimate Hazard Quotients (HQs) for the pharmaceuticals detected in the investigated area...
February 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/28955031/printing-of-small-molecular-medicines-from-the-vapor-phase
#9
Olga Shalev, Shreya Raghavan, J Maxwell Mazzara, Nancy Senabulya, Patrick D Sinko, Elyse Fleck, Christopher Rockwell, Nicholas Simopoulos, Christina M Jones, Anna Schwendeman, Geeta Mehta, Roy Clarke, Gregory E Amidon, Max Shtein
There is growing need to develop efficient methods for early-stage drug discovery, continuous manufacturing of drug delivery vehicles, and ultra-precise dosing of high potency drugs. Here we demonstrate the use of solvent-free organic vapor jet printing to deposit nanostructured films of small molecular pharmaceutical ingredients, including caffeine, paracetamol, ibuprofen, tamoxifen, BAY 11-7082 and fluorescein, with accuracy on the scale of micrograms per square centimeter, onto glass, Tegaderm, Listerine tabs, and stainless steel microneedles...
September 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/28954512/ionic-liquid-forms-of-weakly-acidic-drugs-in-oral-lipid-formulations-preparation-characterization-in-vitro-digestion-and-in-vivo-absorption-studies
#10
Yasemin Sahbaz, Tri-Hung Nguyen, Leigh Ford, Claire L McEvoy, Hywel D Williams, Peter J Scammells, Christopher J H Porter
This study aimed to transform weakly acidic poorly water-soluble drugs (PWSD) into ionic liquids (ILs) to promote solubility in, and the utility of, lipid-based formulations. Ionic liquids (ILs) were formed directly from tolfenamic acid (Tolf), meclofenamic acid, diclofenac, and ibuprofen by pairing with lipophilic counterions. The drug-ILs were obtained as liquids or low melting solids and were significantly more soluble (either completely miscible or highly soluble) in lipid based, self-emulsifying drug delivery systems (SEDDS) when compared to the equivalent free acid...
November 6, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28937221/in-vivo-dissolution-and-systemic-absorption-of-immediate-release-ibuprofen-in-human-gastrointestinal-tract-under-fed-and-fasted-conditions
#11
Duxin Sun, Jason R Baker, Bo Wen, Ann Frances, Huixia Zhang, Alex Yu, Ting Zhao, Yasuhiro Tsume, Manjunath Pai, Barry Bleske, Xinyuan Zhang, R Lionberger, Allen Lee, Gordon Amidon, William L Hasler, Mark Koenigsknecht
PURPOSE: In vivo drug dissolution in the gastrointestinal (GI) tract is largely unmeasured. The purpose of this clinical study was to evaluate the in vivo drug dissolution and systemic absorption of the BCS Class IIa drug ibuprofen under fed and fasted conditions by direct sampling of stomach and small intestinal luminal content. Expanding current knowledge of drug dissolution in vivo will help to establish physiologically relevant in vitro models predictive of drug dissolution. METHODS: A multi-lumen GI catheter was orally inserted into the GI tract of healthy human subjects...
September 22, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28899844/a-new-lipid-formulation-of-low-dose-ibuprofen-shows-non-inferiority-to-high-dose-standard-ibuprofen-the-flare-study-flaring-arthralgia-relief-evaluation-in-episodic-flaring-knee-pain-a-randomised-double-blind-study
#12
S M A Bierma-Zeinstra, J Brew, K Stoner, R Wilson, A Kilbourn, P G Conaghan
OBJECTIVE: To investigate short-term efficacy and safety of a novel lipid ibuprofen formulation 1200 mg/day compared with standard ibuprofen 1200 mg/day and 2400 mg/day in episodic knee arthralgia/flaring pain. DESIGN: Multicentre, randomised, double-blind, 3-arm, non-inferiority trial conducted at 27 primary care centres. Adults with ≥1 knee flare episode within 12 months were recruited within 24 h of new flare with pain severity ≥5 on a 0-10 numerical rating scale (NRS)...
September 9, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28875479/development-of-an-enantioselective-and-biomarker-informed-translational-population-pharmacokinetic-pharmacodynamic-model-for-etodolac
#13
Carolina de Miranda Silva, Adriana Rocha, Eduardo Tozatto, Lucienir Maria da Silva, Eduardo Antônio Donadi, Teresa Dalla Costa, Vera Lucia Lanchote, Stephan Schmidt, Jürgen B Bulitta
Cyclooxygenase-2 (COX-2) isoform has a critical role in the development of pain. Inhibition of COX-2 in vitro serves as a biomarker for nonsteroidal anti-inflammatory drugs (NSAIDs). The NSAID concentrations yielding 80% COX-2 inhibition (IC80) correlate with therapeutic doses to achieve analgesia across multiple COX-2 inhibitors. However, there are no time-course models relating COX-2 inhibition with decreased pain. This study aimed to characterize the relationship between NSAID concentrations, in vitro COX-2 inhibition, and acute pain decrease in humans over time by a translational approach using clinical pharmacokinetic and literature reported in vitro and clinical pharmacodynamic data...
November 2017: AAPS Journal
https://www.readbyqxmd.com/read/28834248/high-doses-of-anti-inflammatory-drugs-compromise-muscle-strength-and-hypertrophic-adaptations-to-resistance-training-in-young-adults
#14
M Lilja, M Mandić, W Apró, M Melin, K Olsson, S Rosenborg, T Gustafsson, T R Lundberg
AIMS: This study tested the hypothesis that high doses of anti-inflammatory drugs would attenuate the adaptive response to resistance training compared with low doses. METHODS: Healthy men and women (aged 18-35 years) were randomly assigned to daily consumption of ibuprofen (IBU; 1200 mg; n = 15) or acetylsalicylic acid (ASA; 75 mg; n = 16) for 8 weeks. During this period, subjects completed supervised knee-extensor resistance training where one leg was subjected to training with maximal volitional effort in each repetition using a flywheel ergometer (FW), while the other leg performed conventional (work-matched across groups) weight-stack training (WS)...
August 21, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28770976/non-steroidal-anti-inflammatory-drugs-nsaids-for-chronic-non-cancer-pain-in-children-and-adolescents
#15
REVIEW
Christopher Eccleston, Tess E Cooper, Emma Fisher, Brian Anderson, Nick Mr Wilkinson
BACKGROUND: Pain is a common feature of childhood and adolescence around the world, and for many young people, that pain is chronic. The World Health Organization guidelines for pharmacological treatments for children's persisting pain acknowledge that pain in children is a major public health concern of high significance in most parts of the world. While in the past pain was largely dismissed and was frequently left untreated, views on children's pain have changed over time, and relief of pain is now seen as important...
August 2, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28664339/metabolite-profiling-of-carbamazepine-and-ibuprofen-in-solea-senegalensis-bile-using-high-resolution-mass-spectrometry
#16
Jaume Aceña, Sandra Pérez, Peter Eichhorn, Montserrat Solé, Damià Barceló
The widespread occurrence of pharmaceuticals in the aquatic environment has raised concerns about potential adverse effects on exposed wildlife. Very little is currently known on exposure levels and clearance mechanisms of drugs in marine fish. Within this context, our research was focused on the identification of main metabolic reactions, generated metabolites, and caused effects after exposure of fish to carbamazepine (CBZ) and ibuprofen (IBU). To this end, juveniles of Solea senegalensis acclimated to two temperature regimes of 15 and 20 °C for 60 days received a single intraperitoneal dose of these drugs...
September 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28623834/nitrate-formation-during-ozonation-as-a-surrogate-parameter-for-abatement-of-micropollutants-and-the-n-nitrosodimethylamine-ndma-formation-potential
#17
Yang Song, Florian Breider, Jun Ma, Urs von Gunten
In this study, nitrate formation from ammonium and/or dissolved organic nitrogen (DON) was investigated as a novel surrogate parameter to evaluate the abatement of micropollutants during ozonation of synthetic waters containing natural organic matter (NOM) isolates, a natural water and secondary wastewater effluents. Nitrate formation during ozonation was compared to the changes in UV absorbance at 254 nm (UVA254) including the effect of pH. For low specific ozone doses UVA254 was abated more efficiently than nitrate was formed...
October 1, 2017: Water Research
https://www.readbyqxmd.com/read/28569569/nonsteroidal-anti-inflammatory-drugs-and-cardiovascular-safety-translating-pharmacological-data-into-clinical-readouts
#18
REVIEW
Stefania Tacconelli, Annalisa Bruno, Rosalia Grande, Patrizia Ballerini, Paola Patrignani
The pharmacological management of pain includes the use of nonsteroidal anti-inflammatory drugs(NSAIDs). They comprise traditional(t) NSAIDs and selective cyclooxygenase(COX)-2 inhibitors (named coxibs). The analgesic and anti-inflammatory effects of NSAIDs are dependent on the extent and duration of COX-2 inhibition in the spinal cord and inflammatory sites. However, the simultaneous inhibition of COX-2 in the vasculature translates into a prothrombotic phenotype and promotes hypertension and heart failure...
July 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28540716/single-dose-oral-ketoprofen-or-dexketoprofen-for-acute-postoperative-pain-in-adults
#19
REVIEW
Helen Gaskell, Sheena Derry, Philip J Wiffen, R Andrew Moore
BACKGROUND: This review is an update of "Single dose oral ketoprofen and dexketoprofen for acute postoperative pain in adults" last updated in Issue 4, 2009. Ketoprofen is a non-selective nonsteroidal anti-inflammatory drug (NSAID) used to treat acute and chronic painful conditions. Dexketoprofen is the (S)-enantiomer, which is believed to confer analgesia. Theoretically dexketoprofen is expected to provide equivalent analgesia to ketoprofen at half the dose, with a consequent reduction in gastrointestinal adverse events...
May 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28536986/evaluation-of-anti-inflammatory-and-ulcerogenic-potential-of-zinc-ibuprofen-and-zinc-naproxen-complexes-in-rats
#20
Magdalena Jarosz, Natalia Szkaradek, Henryk Marona, Gabriel Nowak, Katarzyna Młyniec, Tadeusz Librowski
Because of numerous indications and high availability, non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly prescribed and used medicines in the world. However, long-term therapy with and improper use of NSAIDs may lead to gastrointestinal damage. Therefore, improving the therapeutic index of the existing drugs has become a priority over the past decades. Considerable attention in the field has been concentrated on metal complexes of non-steroidal anti-inflammatory drugs. The aim of this study is to evaluate the effect of complexation with zinc on the anti-inflammatory and ulcerogenic effects of ibuprofen and naproxen after single and triple intragastric administration to rats...
December 2017: Inflammopharmacology
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