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high doses ibuprofen

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https://www.readbyqxmd.com/read/29313709/association-of-high-dose-ibuprofen-use-lung-function-decline-and-long-term-survival-in-children-with-cystic-fibrosis
#1
Michael W Konstan, Donald R VanDevanter, Gregory S Sawicki, David J Pasta, Aimee J Foreman, Evgueni A Neiman, Wayne J Morgan
RATIONALE: Cystic fibrosis (CF) deaths result primarily from lung function loss, so chronic respiratory therapies intended to preserve lung function are cornerstones of CF care. Although treatment-associated reduction in rate of lung function loss should ultimately improve CF survival, no such relationship has been described for any chronic CF therapy. In part, this is because the ages of most rapid lung function decline -- early adolescence -- precede the median age of CF deaths by more than a decade...
January 9, 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29288707/improving-the-skin-penetration-and-antifebrile-activity-of-ibuprofen-by-preparing-nanoparticles-using-emulsion-solvent-evaporation-method
#2
Yiping Deng, Fengjian Yang, Xiuhua Zhao, Lu Wang, Weiwei Wu, Chang Zu, Mingfang Wu
Ibuprofen (IBU) is an effective analgesic, non-steroidal anti-inflammatory drug. Unfortunately, oral IBU can cause adverse gastrointestinal drug reactions, such as bleeding and ulcerations, and increases the risk for stomach or intestinal perforations. In this study, IBU nanoparticles (IBU-NPs) were prepared through emulsion solvent evaporation and freeze-drying to improve their solubility. IBU nanoemulsion and nanosuspension were optimized through a single-factor experiment. IBU-NPs with a mean particle size of 216...
December 27, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29284661/effect-of-ibuprofen-on-skeletal-muscle-of-dysferlin-null-mice
#3
Alyssa F Collier, Jessica Gumerson, Jace W Jones, Maureen A Kane, Kimmo Lehtimaki, Jukka Puolivali, Sankeerth Manne, Andrea O'Neill, Hillarie P Windish, Toni Ahtoniemi, Bradley A Williams, Douglas E Albrecht, Robert J Bloch
Ibuprofen, a non-steroidal anti-inflammatory drug, and nitric oxide (NO) donors have been reported to reduce the severity of muscular dystrophies in mice associated with the absence of dystrophin or α-sarcoglycan, but their effects on mice that are dystrophic due to the absence of dysferlin have not been examined. We have tested ibuprofen, as well as isosorbide dinitrate (ISDN), an NO donor, to learn if used alone or together they protect dysferlin-null muscle in A/J mice from large strain injury (LSI) induced by a series of high strain lengthening contractions...
December 28, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29277724/supersaturated-silica-lipid-hybrids-super-slh-an-improved-solid-state-lipid-based-oral-drug-delivery-system-with-enhanced-drug-loading
#4
Hayley B Schultz, Nicky Thomas, Shasha Rao, Clive A Prestidge
The method of supersaturation for achieving high drug loads in lipid-based formulations is under exploited and relatively unexplored, especially in the case of solid-state lipid-based formulations. Silica-lipid hybrids are solid-state lipid-based formulations designed for improving the oral delivery of poorly water-soluble drugs. However, their application to compounds of low potency and requiring large doses is limited by their low drug loading capacity. Here, an innovative technique to fabricate supersaturated silica-lipid hybrid formulations (super-SLH) has been established and the relationship between drug load and performance investigated...
December 22, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29275397/short-course-high-dose-ibuprofen-causing-both-early-and-delayed-jejunal-perforations-in-a-non-smoking-man
#5
Aseef Yehiyan, Sowrav Barman, Haren Varia, Stephen Pettit
No abstract text is available yet for this article.
December 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29247518/cardiovascular-safety-of-nsaids-additional-insights-after-precision-and-point-of-view
#6
REVIEW
Carl J Pepine, Paul A Gurbel
Increasing numbers of patients with arthritis use nonsteroidal anti-inflammatory drugs (NSAIDs), some for long periods. The relative cardiovascular safety of NSAID use is of considerable concern, particularly among patients with or at risk of cardiovascular disease. Until recently, the evidence base was limited to older trials with small sample sizes. The large-scale Prospective Randomized Evaluation of Celecoxib Integrated Safety vs Ibuprofen or Naproxen (PRECISION) trial and a recent Bayesian meta-analysis of individual patient data in nearly a half-million patients were undertaken to address some of the existing gaps in knowledge relative to the cardiovascular safety of NSAID use...
December 16, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/29233194/ibuprofen-plasma-concentration-profile-in-deliberate-ibuprofen-overdose-with-circulatory-depression-treated-with-therapeutic-plasma-exchange-a-case-report
#7
Stefanie Geith, Bertold Renner, Christian Rabe, Jochen Stenzel, Florian Eyer
BACKGROUND: Inquiries relating to ibuprofen overdose have more than tripled in the last ten years in our poison control center. Although the vast majority of cases have a benign clinical course, there are few severe or even fatal cases present with refractory circulatory failure. CASE PRESENTATION: We describe a case of a 48 year-old male with suicidal mono-ingestion of approximately 72 g ibuprofen. Despite an initial rapid spontaneous drop in the total ibuprofen plasma concentration (IPC) from 550 to 275 mcg/mL within the first 5 h after admission, the patient developed a circulatory failure, refractory to aggressive fluid resuscitation and high doses of vasopressors...
December 12, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29225976/intensive-care-in-a-patient-with-toxic-epidermal-necrolysis
#8
J Wallenborn, M Fischer
Toxic epidermal necrolysis (TEN) is a serious adverse drug reaction with high lethality, which usually requires intensive-medical care. A 44-year-old man developed generalized exanthema with increasing exfoliation and mucosal involvement after taking allopurinol, ibuprofen, and etoricoxib. The clinical diagnosis of TEN was histologically confirmed. Prednisolone therapy with 3 mg/kg body weight (BW) was not able to prevent further progress to finally 80% of the body surface, and infliximab 5 mg/kg BW was given as a single dose...
2017: Case Reports in Critical Care
https://www.readbyqxmd.com/read/29222744/activation-of-intestinal-gr-fxr-and-ppar%C3%AE-ugt-signaling-exacerbates-ibuprofen-induced-enteropathy-in-mice
#9
Zhiqiang Lu, Yuanfu Lu, Xue Wang, Fangyu Wang, Youcai Zhang
Nonsteroidal anti-inflammatory drugs (NSAIDs)-induced small intestinal injury (enteropathy) occurs in about two-thirds of regular NSAID users. To date, there is no proven-effective treatment for NSAID enteropathy, and its underlying mechanism remains obscure. The present study showed that glucocorticoids are an important determinant of NSAID enteropathy. High dose dexamethasone (DEX, 75 mg/kg) markedly exacerbated the acute toxicity of ibuprofen (IBU, 200 mg/kg) in the small intestine of mice, which was not due to the pregnane-X-receptor pathway...
December 8, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29216480/comparison-of-pharmaceutical-abatement-in-various-water-matrices-by-conventional-ozonation-peroxone-o3-h2o2-and-an-electro-peroxone-process
#10
Huijiao Wang, Juhong Zhan, Weikun Yao, Bin Wang, Shubo Deng, Jun Huang, Gang Yu, Yujue Wang
Pharmaceutical abatement in a groundwater (GW), surface water (SW), and secondary effluent (SE) by conventional ozonation, the conventional peroxone (O3/H2O2), and the electro-peroxone (E-peroxone) processes was compared in batch tests. SE had significantly more fast-reacting dissolved organic matter (DOM) moieties than GW and SW. Therefore, O3 decomposed much faster in SE than in GW and SW. At specific ozone doses of 0.5-1.5 mg O3/mg dissolved organic carbon (DOC), the application of O3/H2O2 and E-peroxone process (by adding external H2O2 stocks or in-situ generating H2O2 from cathodic O2 reduction during ozonation) similarly enhanced the OH yield from O3 decomposition by ∼5-12% and 5-7% in GW and SW, respectively, compared to conventional ozonation...
November 27, 2017: Water Research
https://www.readbyqxmd.com/read/29182798/pharmacological-interventions-for-pain-relief-during-orthodontic-treatment
#11
REVIEW
Aoife B Monk, Jayne E Harrison, Helen V Worthington, Annabel Teague
BACKGROUND: Pain is a common side effect of orthodontic treatment. It increases in proportion to the amount of force applied to the teeth, and the type of orthodontic appliance used can affect the intensity of the pain. Pain during orthodontic treatment has been shown to be the most common reason for people wanting to discontinue treatment, and has been ranked as the worst aspect of treatment. Although pharmacological methods of pain relief have been investigated, there remains some uncertainty among orthodontists about which painkillers are most suitable and whether pre-emptive analgesia is beneficial...
November 28, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29178434/demonstration-of-an-anti-hyperalgesic-effect-of-a-novel-pan-trk-inhibitor-pf-06273340-in-a-battery-of-human-evoked-pain-models
#12
Peter Loudon, Pieter Siebenga, Donal Gorman, Katrina Gore, Pinky Dua, Guido van Amerongen, Justin L Hay, Geert Jan Groeneveld, Richard P Butt
AIM(S): Inhibitors of nerve growth factor (NGF) reduce pain in several chronic pain indications. NGF signals through tyrosine kinase receptors of the tropomyosin-related kinase (Trk) family and the unrelated p75 receptor. PF-06273340 is a small molecule inhibitor of Trks A, B and C that reduces pain in nonclinical models and this study aimed to investigate the pharmacodynamics of this first in class molecule in humans. METHODS: A randomized, double blind, single dose, placebo and active-controlled 5 period cross-over study was conducted in healthy human subjects (NCT02260947)...
November 27, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29105796/penetration-and-pharmacokinetics-of-non-steroidal-anti-inflammatory-drugs-in-rat-prostate-tissue
#13
Venkata K Yellepeddi, Jayashree Radhakrishnan, Rajan Radhakrishnan
BACKGROUND: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) involves inflammation of the prostate and affects the quality of life of men of all ages. It is well reported in clinical studies that the treatment for CP/CPPS using nonsteroidal anti-inflammatory drugs (NSAIDs) produced favorable outcomes. However, currently, there are no guidelines on choice of the NSAIDs for the treatment of CP/CPPS. Therefore, in the current research study, we evaluated the prostate tissue penetration of four NSAIDs in rats to provide guidance on choice of NSAIDs for the treatment of CP/CPPS...
February 2018: Prostate
https://www.readbyqxmd.com/read/29071151/silodosin-in-the-treatment-of-distal-ureteric-stones-in-children-a-prospective-randomised-placebo-controlled-study
#14
Hazem Elgalaly, Ahmed Eliwa, Mohamed Seleem, Emad Salem, Mohammed Omran, Haitham Shello, Khalid Abdelwahab, Salem Khalil, Mostafa Kamel
OBJECTIVES: To evaluate the possible role of silodosin (a highly selective α1A-adrenoceptor antagonist) in facilitating the passage of distal ureteric stones (DUS) in children, as the role of α-blockers as medical expulsive therapy is well known in adults. PATIENTS AND METHODS: In all, 40 paediatric patients (27 boys and 13 girls) diagnosed with unilateral, single, radiopaque DUS of <10 mm were included in the study. Their mean (SD, range) age was 8.1 (2.7, 5-17) years...
September 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29038738/a-case-of-infective-endocarditis-and-spinal-epidural-abscess-caused-by-streptococcus-mitis-bacteremia
#15
Victoria S Byrd, Attila S Nemeth
A 57-year-old man presented with abdominal pain, hematemesis, and melena. He reported taking high-dose ibuprofen for back pain and drinking several 24-ounce beers daily. Examination was remarkable for icteric sclera, poor dentition, tachycardia, and crescendo-decrescendo murmur at right upper sternal border, radiating to the carotids. Labs revealed leukocytosis, anemia, thrombocytopenia, and elevated liver function tests and INR. Endoscopy demonstrated antral ulcers, duodenitis, and esophagitis. Blood cultures were obtained and broad-spectrum antibiotics started; cultures later grew Streptococcus mitis, and antibiotic coverage was narrowed...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29026363/highly-accelerated-onset-of-hydroxychloroquine-macular-retinopathy
#16
Ethan M Stern, Jordan S Johnson, Donald A Mazzulla
BACKGROUND: Hydroxychloroquine (HCQ, Plaquenil) is often prescribed in lieu of other sulfate antimalarials to treat rheumatologic diseases because of its pharmacologic efficacy and few reported side effects. However, a known potential side effect of HCQ is retinal toxicity. CASE REPORT: A 61-year-old black female presented for screening of ophthalmic disease 2 months after initiation of HCQ for the treatment of polyarthralgia with a positive rheumatoid factor. At the time of the examination, she had taken a cumulative total of 19...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29022772/formulation-and-delivery-strategies-of-ibuprofen-challenges-and-opportunities
#17
Jake Irvine, Afrina Afrose, Nazrul Islam
Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID) is mostly administered orally and topically to relieve acute pain and fever. Due to its mode of action this drug may be useful in the treatment regimens of other, more chronic conditions, like cystic fibrosis. This drug is poorly soluble in aqueous media and thus the rate of dissolution from the currently available solid dosage forms is limited. This leads to poor bioavailability at high doses after oral administration, thereby increasing the risk of unwanted adverse effects...
October 12, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28991796/continuous-transformation-of-chiral-pharmaceuticals-in-enzymatic-membrane-bioreactors-for-advanced-wastewater-treatment
#18
Luong N Nguyen, Faisal I Hai, James A McDonald, Stuart J Khan, William E Price, Long D Nghiem
This study demonstrates continuous enantiomeric inversion and further biotransformation of chiral profens including ibuprofen, naproxen and ketoprofen by an enzymatic membrane bioreactor (EMBR) dosed with laccase. The EMBR showed non-enantioselective transformations, with high and consistent transformation of both (R)- and (S)-ibuprofen (93 ± 6%, n = 10), but lower removals of both enantiomers of naproxen (46 ± 16%, n = 10) and ketoprofen (48 ± 17%, n = 10). Enantiomeric analysis revealed a bidirectional but uneven inversion of the profens, for example 14% inversion of (R)- to (S)- compared to 4% from (S)- to (R)-naproxen...
October 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28983670/analgesia-mis-usage-on-a-dental-emergency-service-a-patient-survey
#19
Geert Hommez, B Ongena, R G E C Cauwels, P De Paepe, V Christiaens, W Jacquet
OBJECTIVES: Analgesics are one of the most frequently used medicines. Self-medication and misuse have been described in the literature. The purpose of this study was to document analgesic (mis)use in a population seeking emergency dental treatment. MATERIAL AND METHODS: Patients consulting a dental emergency service were randomly asked to complete a questionnaire on analgesic use, knowledge and information on the analgesics and on their pain history. A photobook was used as an aid to identify products used...
October 5, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28962074/study-of-pharmaceuticals-in-surface-and-wastewater-from-cuernavaca-morelos-mexico-occurrence-and-environmental-risk-assessment
#20
José Abraham Rivera-Jaimes, Cristina Postigo, Rosa María Melgoza-Alemán, Jaume Aceña, Damia Barceló, Miren López de Alda
The present work describes the first known study to date on the occurrence of pharmaceuticals in surface water and wastewater of Cuernavaca, the capital of the state of Morelos (México). Selected pharmaceuticals (a total of 35) were extracted from the collected water samples with a generic solid phase extraction (SPE) protocol and determined in the sample extracts by means of high-performance liquid chromatography coupled to electrospray ionization-tandem mass spectrometry (HPLC-ESI-MS/MS). A screening level risk assessment combining the measured environmental concentrations (MECs) with dose-response data based on predicted no-effect concentrations (PNECs) was also applied to estimate Hazard Quotients (HQs) for the pharmaceuticals detected in the investigated area...
February 1, 2018: Science of the Total Environment
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