keyword
https://read.qxmd.com/read/38545499/intravenous-s-ketamine-s-analgesic-efficacy-in-third-molar-surgery-a-randomized-placebo-controlled-double-blind-clinical-trial
#1
JOURNAL ARTICLE
Lars B Eriksson, Torsten Gordh, Rolf Karlsten, Riccardo LoMartire, Andreas Thor, Åke Tegelberg
BACKGROUND: In most cases, a combination of paracetamol and ibuprofen are the optimal treatment for postoperative pain in third molar surgery. If stronger analgesia is required, opioids are traditionally administered. In day-case, surgery; however, opioids should be avoided. Thus, the anaesthetic agent S-ketamine in analgesic doses might be preferred. METHODS: The study was designed as a randomized placebo-controlled double-blind clinical trial. The study enrolled healthy subjects according to the American Society of Anaesthesiologists classification; I or II (ASA), aged 18 to 44 years, with a body weight between 50 and 100 kg...
April 2024: British Journal of Pain
https://read.qxmd.com/read/38492032/ototoxic-and-nephrotoxic-drugs-in-neonatal-intensive-care-units-results-of-a-spanish-and-italian-survey
#2
JOURNAL ARTICLE
Cristina Arribas, Nunzia Decembrino, Genny Raffaeli, Ilaria Amodeo, Juan Luis González-Caballero, Mónica Riaza, Roberto Ortiz-Movilla, Luca Massenzi, Camilla Gizzi, Gabriella Araimo, Donatella Cattarelli, Salvatore Aversa, Stefano Martinelli, Simonetta Frezza, Luigi Orfeo, Fabio Mosca, Giacomo Cavallaro, Felipe Garrido
UNLABELLED: Neonates face heightened susceptibility to drug toxicity, often exposed to off-label medications with dosages extrapolated from adult or pediatric studies. Premature infants in Neonatal Intensive Care Units (NICUs) are particularly at risk due to underdeveloped pharmacokinetics and exposure to multiple drugs. The study aimed to survey commonly used medications with a higher risk of ototoxicity and nephrotoxicity in Spanish and Italian neonatal units. A prospective cross-sectional study was conducted in Italian and Spanish neonatal units using a web-based survey with 43 questions...
March 16, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38318274/a-rare-cause-of-recurrent-pericarditis
#3
Georgios Aletras, Maria Stratinaki, Maria Bachlitzanaki, Theodora Georgopoulou, Emmanouil G Foukarakis
Recurrent pericarditis poses a significant challenge to clinicians, particularly when patients are unresponsive or intolerant to conventional treatments. Accurate diagnosis of recurrent pericarditis, potentially facilitated by collaboration with other medical specialties, is crucial for ensuring timely and appropriate treatment of symptoms and prevention of further episodes. We present a case of a 52-year-old male patient with a history of multiple episodes of pericarditis, who was admitted to the Cardiology Department due to another recurrence...
February 2024: Curēus
https://read.qxmd.com/read/38303016/drug-drug-interaction-assessment-based-on-a-large-scale-spontaneous-reporting-system-for-hepato-and-renal-toxicity-and-thrombocytopenia-with-concomitant-low-dose-methotrexate-and-analgesics-use
#4
JOURNAL ARTICLE
Takeshi Honma, Kenji Onda, Koichi Masuyama
BACKGROUND: Methotrexate (MTX) is the cornerstone of rheumatoid arthritis (RA) treatment and is highly effective with low-dose intermittent administration. MTX is occasionally used in combination with non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen (APAP)/paracetamol for pain or inflammation control. With MTX treatment, the side effects, such as hepatotoxicity, renal failure, and myelosuppression should be considered. These are also seen with analgesics treatment. METHODS: We used a large spontaneously reported adverse event database (FAERS [JAPIC AERS]) to analyze whether the reporting of adverse events increased upon MTX and analgesic therapy in patients with RA...
February 1, 2024: BMC Pharmacology & Toxicology
https://read.qxmd.com/read/38301081/efficacy-of-ibuprofen-lysine-on-first-trimester-abortionrelated-pain-and-hemorrhage-a-randomized-tripleblinded-clinical-trial
#5
JOURNAL ARTICLE
Zahra Najmi, Atousa Dabiri Oskoei, Shabnam Tofighi, Hamideh Gholami, Lida Garrosi, Faranak Amini
BACKGROUND: Some recent trials have reported high efficacy for nonsteroidal anti-inflammatory drugs (NSAIDs) in relieving medical abortion-related pain. The aim of this study was to determine the beneficial effect of oral NSAIDs (ibuprofen lysine) in reduction of pain and hemorrhage in first-trimester medical abortion. METHODS: This randomized triple-blinded clinical trial was performed on 98 pregnant women who were candidate for medical abortion within the first-trimester period (gestational age<12 weeks)...
April 1, 2023: Archives of Iranian Medicine
https://read.qxmd.com/read/38198469/the-dose-response-effects-of-flurbiprofen-indomethacin-ibuprofen-and-naproxen-on-primary-skeletal-muscle-cells
#6
JOURNAL ARTICLE
Brandon M Roberts, Alyssa V Geddis, Ronald W Matheny
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, flurbiprofen, naproxen sodium, and indomethacin are commonly employed for their pain-relieving and inflammation-reducing qualities. NSAIDs work by blocking COX-1 and/or COX-2, enzymes which play roles in inflammation, fever, and pain. The main difference among NSAIDs lies in their affinity to these enzymes, which in turn, influences prostaglandin secretion, and skeletal muscle growth and regeneration. The current study investigated the effects of NSAIDs on human skeletal muscle cells, focusing on myoblast proliferation, differentiation, and muscle protein synthesis signaling...
December 2024: Journal of the International Society of Sports Nutrition
https://read.qxmd.com/read/38180091/ibuprofen-for-acute-postoperative-pain-in-children
#7
JOURNAL ARTICLE
Sara Pessano, Natasha R Gloeck, Luca Tancredi, Martin Ringsten, Ameer Hohlfeld, Sumayyah Ebrahim, Martina Albertella, Tamara Kredo, Matteo Bruschettini
BACKGROUND: Children often require pain management following surgery to avoid suffering. Effective pain management has consequences for healing time and quality of life. Ibuprofen, a frequently used non-steroidal anti-inflammatory drug (NSAID) administered to children, is used to treat pain and inflammation in the postoperative period. OBJECTIVES: 1) To assess the efficacy and safety of ibuprofen (any dose) for acute postoperative pain management in children compared with placebo or other active comparators...
January 5, 2024: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/38114217/-therapeutic-effect-of-leonuri-herba-aqueous-decoction-on-primary-dysmenorrhea-in-rats-and-its-metabolomic-analysis
#8
JOURNAL ARTICLE
Liu-Jun Wu, Yan Chen, Zi-Wei Lin, Chen Sun, Liang Xiong, Xiao-Fang Xie, Cheng Peng
This study aimed to investigate the therapeutic effect of Leonuri Herba aqueous decoction on primary dysmenorrhea(PD) and explore the underlying mechanism in conjunction with untargeted metabolomics. Forty adult female rats were randomly divi-ded into a normal group, a model control group, ibuprofen(0.12 g·kg~(-1)) group, and high-and low-dose Leonuri Herba aqueous decoction(5 and 2.5 g·kg~(-1)) groups, with eight rats in each group. The PD rat model was prepared using intramuscular injection of estradiol benzoate combined with intraperitoneal injection of pitocin...
November 2023: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/38001937/synergistic-antimicrobial-effects-of-ibuprofen-combined-with-standard-of-care-antibiotics-against-cystic-fibrosis-pathogens
#9
JOURNAL ARTICLE
Qingquan Chen, Marleini Ilanga, Sabona B Simbassa, Bhagath Chirra, Kush N Shah, Carolyn L Cannon
Cystic fibrosis (CF) is a common life-shortening genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Lungs of CF patients are often colonized or infected with microorganisms requiring frequent courses of antibiotics. Antibiotic-resistant bacterial infections have been a growing concern in CF patients. Chronic bacterial infections and concomitant airway inflammation damage the lungs, ultimately leading to respiratory failure. Several clinical trials have demonstrated that high-dose ibuprofen reduces the rate of pulmonary function decline in CF patients...
October 30, 2023: Biomedicines
https://read.qxmd.com/read/37999895/ibuprofen-inhibits-anaplastic-thyroid-cells-in-vivo-and-in-vitro-by-triggering-nlrp3-asc-gsdmd-dependent-pyroptosis
#10
JOURNAL ARTICLE
Haohao Guo, Runsheng Ma, Yifei Zhang, Keyu Yin, Gongbo Du, Fanxiang Yin, Hongqiang Li, Ziyang Wang, Detao Yin
Pyroptosis is a novel type of proinflammatory programmed cell death that is associated with inflammation, immunity, and cancer. Anaplastic thyroid carcinoma (ATC) has a high fatality rate, and there is no effective or standard treatment. The disease progresses rapidly and these tumors can invade the trachea and esophagus, leading to breathing and swallowing difficulties. Hence, new treatment methods are greatly needed. Ibuprofen is a common drug that can exert antitumor effects in some cancers. In this study, we demonstrated in vitro and in vivo that ibuprofen can induce ATC pyroptosis...
November 24, 2023: Inflammopharmacology
https://read.qxmd.com/read/37965564/diclofenac-ibuprofen-and-paracetamol-biodegradation-overconsumed-non-steroidal-anti-inflammatories-drugs-at-covid-19-pandemic
#11
REVIEW
Beatriz L Ferreira, Dionisia P Ferreira, Swanny F Borges, Adriana M Ferreira, Fabricio H Holanda, João G M Ucella-Filho, Rodrigo Alves S Cruz, Willian G Birolli, Rafael Luque, Irlon M Ferreira
The consumption of non-steroidal anti-inflammatory drugs (NSAIDs) have increased significantly in the last years (2020-2022), especially for patients in COVID-19 treatment. NSAIDs such as diclofenac, ibuprofen, and paracetamol are often available without restrictions, being employed without medical supervision for basic symptoms of inflammatory processes. Furthermore, these compounds are increasingly present in nature constituting complex mixtures discarded at domestic and hospital sewage/wastewater. Therefore, this review emphasizes the biodegradation of diclofenac, ibuprofen, and paracetamol by pure cultures or consortia of fungi and bacteria at in vitro , in situ , and ex situ processes...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/37964084/development-of-sustained-release-system-based-on-high-water-absorbable-gel-formation-using-croscarmellose-sodium-alkaline-excipients-and-hpmc-acsh-sr-system-novel-application-of-croscarmellose-sodium-as-a-gel-former
#12
JOURNAL ARTICLE
Masato Gomi, Naoya Mizutani, Ryotaro Senoo, Noriaki Matsubara, Ayahisa Watanabe, Masato Maruyama, Go Kimura, Kazutaka Higaki
PURPOSE: Croscarmellose sodium, generally used as a superdisintegrant in pharmaceutical formulations, is hydrolyzed to form the gel structure under basic pH conditions. Utilizing this property of croscarmellose sodium, we developed a novel sustained release (SR) system. METHODS: Immediate release (IR) and SR tablets containing croscarmellose sodium, alkaline excipients and/or hydroxypropyl methylcellulose (HPMC) were prepared and examined for wet strength and in vitro drug release behavior...
November 14, 2023: Pharmaceutical Research
https://read.qxmd.com/read/37954704/the-impact-of-non-opioid-analgesic-usage-on-total-opioid-load-during-traumatic-brain-injury-rehabilitation-a-retrospective-study
#13
JOURNAL ARTICLE
Joshua D King, Kylo Cautivar, Duc A Tran, Mohammad Ali, Nicholas Schmidt, Michelle McSkane, Eugene Pak
Background Patients staying in acute rehabilitation often use large amounts of opioids during their stay. There are a number of reasons for this increased opioid exposure, including but not limited to daily exercises with physical and occupational therapists, increased demand on a healing body, and use of previously atrophying musculature. Some physiatrists have noticed that patients who concurrently are prescribed medications such as Robaxin seem to require fewer opioids during their stay in acute rehabilitation...
October 2023: Curēus
https://read.qxmd.com/read/37941578/correlation-of-effectiveness-and-tolerability-assessments-from-a-pharmacy-based-observational-study-investigating-the-fixed-dose-combination-of-400-mg-ibuprofen-plus-100-mg-caffeine-for-the-treatment-of-acute-headache
#14
JOURNAL ARTICLE
Charly Gaul, Stefanie Förderreuther, Walter Lehmacher, Thomas Weiser
INTRODUCTION: Observational studies are valuable for investigating correlations between patient-reported treatment outcomes. In this study, we report a secondary analysis of a published pharmacy-based observational (patient-centered "real-world" outcomes) study on experiences reported by patients who treated their headache with an over-the-counter analgesic. METHODS: A pharmacy-based exploratory survey was conducted in German community pharmacies. Patients buying a fixed-dose analgesic combination product (400 mg ibuprofen + 100 mg caffeine; IbuCaff) to treat their headache were offered a questionnaire that contained-among others-questions about time to onset of pain relief (OPR), assessment of time to onset of pain relief (AOPR), assessment of efficacy and tolerability, and pain intensity 2 h after intake...
2023: Frontiers in Neurology
https://read.qxmd.com/read/37927669/beyond-the-norm-a-case-of-multiorgan-injury-triggered-by-ibuprofen
#15
Shawn Medford, Abdelwahab Jalal Eldin, Ahmed Brgdar, Lilian Obwolo, Ademola S Ojo, Constance Mere, Ahmed Ali
We report the case of a 71-year-old African American male with a history of chronic obstructive pulmonary disease (COPD), heart failure, vitiligo, penicillin allergy, and cocaine use, who presented with respiratory symptoms and was diagnosed with sepsis, COVID-19 pneumonia, exacerbation of COPD, and acute kidney injury (AKI). Treatment included antibiotics and high-dose steroids. The patient developed thrombocytopenia, autoimmune hemolytic anemia, acute liver failure, and interstitial nephritis associated with prolonged ibuprofen use...
October 2023: Curēus
https://read.qxmd.com/read/37830308/perfusion-analysis-using-high-definition-indocyanine-green-angiography-in-burn-comb-model
#16
JOURNAL ARTICLE
Zhaolong Jiang, Junqiang Wu, Yunjie Qiu, Guoliang Shen
Indocyanine green angiography (ICGA) has been widely employed for quantitative evaluation of the rat comb burn model, but the imaging equipment, imaging protocol, and fluorescence data interpretation of ICGA remain unsatisfactory. The aim of this study is to provide better solutions for the application of ICGA on perfusion analysis. The rat comb burn model was established under a series of different comb contact durations including 10, 20, 25, 30, 35, and 40 s. ICGA was used to analyze wound perfusion...
October 13, 2023: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://read.qxmd.com/read/37750475/non-steroidal-anti-inflammatory-drugs-for-treatment-of-cancer-cachexia-a-systematic-review
#17
REVIEW
Megan Bowers, Brittany Cucchiaro, Joanne Reid, Adrian Slee
Cancer cachexia (CC) is a multifactorial syndrome driven by inflammation, defined by ongoing loss of skeletal muscle mass (with or without loss of fat mass) that cannot be fully reversed by conventional nutritional support. CC leads to progressive functional impairment, with its clinical management complicated and limited therapeutic options available. The objective of this review was to assess the efficacy and safety of non-steroidal anti-inflammatory drugs (NSAIDs) on patient-centred outcomes in patients with CC...
September 26, 2023: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/37662601/a-rare-case-of-takayasu-arteritis-presenting-as-pericarditis-with-effusion
#18
Ian J Robertson, David K Mecham, Lisa M Conte, Michael F Loncharich
Takayasu arteritis (TAK) is a rare large-vessel vasculitis that is seen primarily in young females of Asian descent and is infrequently diagnosed in the United States. Pericardial effusion with or without pericarditis as a presenting feature of TAK is rare, with only about five percent of cases of pericarditis attributable to any autoimmune etiology. We present a case of a 22-year-old Caucasian woman who presented with a large, symptomatic pericardial effusion of unclear etiology, who after extensive laboratory workup and imaging to include whole-body positron emission tomography (PET) was diagnosed with TAK...
2023: Case Reports in Rheumatology
https://read.qxmd.com/read/37630410/preclinical-evaluation-of-a-new-series-of-albumin-binding-177-lu-labeled-psma-based-low-molecular-weight-radiotherapeutics
#19
JOURNAL ARTICLE
Srikanth Boinapally, Suresh Alati, Zirui Jiang, Yu Yan, Alla Lisok, Rajan Singh, Gabriela Lofland, Il Minn, Robert F Hobbs, Martin G Pomper, Sangeeta Ray Banerjee
Prostate-specific membrane antigen (PSMA)-based low-molecular-weight agents using beta(β)-particle-emitting radiopharmaceuticals is a new treatment paradigm for patients with metastatic castration-resistant prostate cancer. Although results have been encouraging, there is a need to improve the tumor residence time of current PSMA-based radiotherapeutics. Albumin-binding moieties have been used strategically to enhance the tumor uptake and retention of existing PSMA-based investigational agents. Previously, we developed a series of PSMA-based, β-particle-emitting, low-molecular-weight compounds...
August 21, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37619682/micro-array-patch-assisted-transdermal-delivery-of-high-dose-ibuprofen-sodium-using-thermoresponsive-sodium-alginate-poly-vinylcaprolactam-in-situ-gels-depot
#20
JOURNAL ARTICLE
Samiullah Khan, Muhammad Usman Minhas
Current study reports the combined technique of microneedle array patches and thermoresponsive gels. Microneedles array patch mediated insitu skin depots were evaluated for sustain drug delivery using sodium alginate/Poly (vinylcaprolactam) thermoresponsive gels. Their phase transition property from sol-gel state was monitored with AR2000 rheometer. Ibuprofen sodium was loaded in optimized formulations. The non-soluble cross-linked microneedle array patches (MAPs) were prepared from variable biocompatible polymers using silicone micromoulds...
August 22, 2023: International Journal of Biological Macromolecules
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