Reo Takahashi, Shin-Nosuke Isshiki, Mayuka Hakozaki, Yuko Kanno, Shota Uesugi, Takuya Koseki, Yoshihito Shiono
Two novel aromatic polyketides 1 and 3 and five known compounds, (4 S ,10 S )-talaroflavone ( 2 ), altenuene ( 4 ), isoaltenuene ( 5 ), alternariol ( 6 ), and altenusin ( 7 ), were isolated from an endophytic strain of Alternaria alternata SI-694. The structures of the new compounds, including their absolute configurations, were elucidated by NMR, IR, UV, and ECD spectroscopies, and the phytotoxicities of the isolated compounds were also evaluated. Altenusin ( 7 ) showed moderate cytotoxicity against HL-60 cells, with an IC50 of 6...
April 22, 2024: Natural Product Research