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https://www.readbyqxmd.com/read/27921235/transplantation-of-collagen-scaffold-with-autologous-bone-marrow-mononuclear-cells-promotes-functional-endometrium-reconstruction-via-downregulating-%C3%AE-np63-expression-in-asherman-s-syndrome
#1
Guangfeng Zhao, Yun Cao, Xianghong Zhu, Xiaoqiu Tang, Lijun Ding, Haixiang Sun, Juan Li, Xinan Li, Chenyan Dai, Tong Ru, Hui Zhu, Jingjie Lu, Caimei Lin, Jingmei Wang, Guijun Yan, Huiyan Wang, Lei Wang, Yimin Dai, Bin Wang, Ruotian Li, Jianwu Dai, Yan Zhou, Yali Hu
Asherman's syndrome (AS) is a common disease that presents endometrial regeneration disorder. However, little is known about its molecular features of this aregenerative endometrium in AS and how to reconstruct the functioning endometrium for the patients with AS. Here, we report that ΔNp63 is significantly upregulated in residual epithelial cells of the impaired endometrium in AS; the upregulated-ΔNp63 induces endometrial quiescence and alteration of stemness. Importantly, we demonstrate that engrafting high density of autologous bone marrow mononuclear cells (BMNCs) loaded in collagen scaffold onto the uterine lining of patients with AS downregulates ΔNp63 expression, reverses ΔNp63-induced pathological changes, normalizes the stemness alterations and restores endometrial regeneration...
December 1, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27856386/reproductive-outcome-in-patients-with-intrauterine-adhesions-following-hysteroscopic-adhesiolysis-experience-from-the-largest-women-s-hospital-in-china
#2
Limei Chen, Hongwei Zhang, Qing Wang, Feng Xie, Shujun Gao, Yu Song, Jing Dong, Hua Feng, Kangyun Xie, Long Sui
STUDY OBJECTIVE: To analyze the reproductive outcome of hysteroscopic adhesiolysis and assess the diagnostic accuracy of transvaginal ultrasonography (TVS) in infertile women resulting from intrauterine adhesions (IUAs) DESIGN: Retrospective , cross-sectional study (Canadian Task Force classification II-2). SETTING: University tertiary referral center PATIENTS: Three hundred and fifty seven patients with mild, moderate, and severe IUAs underwent hysteroscopic adhesiolysis between January 2012 and December 2015 INTERVENTIONS: Hysteroscopic adhesiolysis in the outpatient analgesic setting for infertility and IUAs...
November 14, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27678984/reproductive-outcome-of-patients-with-asherman-s-syndrome-after-hysteroscopic-adhesiolysis
#3
B Dilbaz, F Akpinar, S Altinbas, S Yilmaz, R Ozelci, S Dilbaz
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27678787/asherman-s-in-disguise-a-very-unusual-presentation
#4
F Moiety, H Saleh
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27678766/reproductive-outcomes-of-10-years-asherman-s-surgery
#5
M Hanstede, M H Emanuel
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27678648/treatment-of-asherman-s-syndrome-in-an-outpatient-hysteroscopy-setting
#6
O Bougie, K Lortie, I Chen, H Shenassa, S S Singh
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27670361/high-molecular-weight-hyaluronic-acid-inhibits-fibrosis-of-endometrium
#7
Yi Zhu, Jianguo Hu, Tinghe Yu, Yan Ren, Lina Hu
BACKGROUND Elevated fibrosis has been found in patients with intrauterine adhesion, which indicates that fibrotic factors may play a critical role in formation of intrauterine adhesion. The aim of this study was to identify the effect of hyaluronic acid (HA) at high and low molecular weight on fibrosis of the endometrium in a mouse model of Asherman's syndrome. MATERIAL AND METHODS Endometrial fibrosis in a mouse model of Asherman's syndrome was confirmed. Then HA at high and low molecular weight was injected into the uterine cavity...
September 27, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27664218/autologous-menstrual-blood-derived-stromal-cells-transplantation-for-severe-asherman-s-syndrome
#8
Jichun Tan, Pingping Li, Qiushi Wang, Yaxuan Li, Xiaoni Li, Dongni Zhao, Xiaoyan Xu, Lin Kong
STUDY QUESTION: Does autologous transplantation of menstrual blood-derived stromal cells (menSCs) regenerate endometrium to support pregnancy in patients with severe Asherman's syndrome (AS)? SUMMARY ANSWER: Autologous menSCs transplantation significantly increases endometrial thickness (ET) for women with severe AS. WHAT IS KNOWN ALREADY: AS is a major cause of secondary infertility in women. Cell transplantation has been tried in a few clinical cases with encouraging results...
September 22, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27258236/endometrial-scratching-what-the-data-show
#9
Xavier Santamaria, Nora Katzorke, Carlos Simón
PURPOSE OF REVIEW: Since its first description in 2003, the endometrial scratching procedure has been the topic of over 1000 studies. This procedure, used to improve endometrial receptivity for assisted reproduction, is accessible - any gynecologist can easily perform it - and has been adapted into clinical routine by some reproductive units. However, the available data are controversial, and no biological plausibility exists to support the use of this intervention. This study aims to critically review the existing data, focusing on the last 2 years, regarding the efficiency of endometrial scratching...
August 2016: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27110522/reproductive-outcome-of-patients-with-asherman-s-syndrome-a-saims-experience
#10
Shilpa Bhandari, Priya Bhave, Ishita Ganguly, Asha Baxi, Pallavi Agarwal
BACKGROUND: The purpose of the study was to evaluate menstrual and reproductive outcome in patients diagnosed with Asherman's syndrome on hysteroscopy and to assess the role of hysteroscopic adhesiolysis. METHODS: A prospective study was performed for patients having intrauterine adhesion at a tertiary care teaching hospital, Indore, India for a period of 2 years. Findings at hysteroscopy, details of adhesiolysis, changes in menstrual pattern following adhesiolysis, need for repeat procedure and fertility outcome were prospectively collected...
October 2015: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/27057384/a-10-year-review-of-the-clinical-presentation-and-treatment-outcome-of-asherman-s-syndrome-at-a-center-with-limited-resources
#11
I U Takai, A S Kwayabura, E A Ugwa, A Idrissa, J Y Obed, M Bukar
BACKGROUND: Many women suffer from some degree of intrauterine adhesions (IUAs) presenting with various clinical symptoms and signs. Hysteroscopy is the mainstay of diagnosis, classification, and treatment of the IUA. AIM: This study was undertaken to review the clinical features and treatment outcome in patients diagnosed with Asherman's syndrome at the University of Maiduguri Teaching Hospital (UMTH), Maiduguri, over a 10 years period, 1997-2006. SUBJECTS AND METHODS: This is a retrospective study of cases of Asherman's syndrome managed at the UMTH over a 10-year period, from January 1, 1997 to December 31, 2006...
November 2015: Annals of Medical and Health Sciences Research
https://www.readbyqxmd.com/read/27005892/autologous-cell-therapy-with-cd133-bone-marrow-derived-stem-cells-for-refractory-asherman-s-syndrome-and-endometrial-atrophy-a-pilot-cohort-study
#12
Xavier Santamaria, Sergio Cabanillas, Irene Cervelló, Cristina Arbona, Francisco Raga, Jaime Ferro, Julio Palmero, Jose Remohí, Antonio Pellicer, Carlos Simón
STUDY QUESTION: Could cell therapy using autologous peripheral blood CD133+ bone marrow-derived stem cells (BMDSCs) offer a safe and efficient therapeutic approach for patients with refractory Asherman's syndrome (AS) and/or endometrial atrophy (EA) and a wish to conceive? SUMMARY ANSWER: In the first 3 months, autologous cell therapy, using CD133+ BMDSCs in conjunction with hormonal replacement therapy, increased the volume and duration of menses as well as the thickness and angiogenesis processes of the endometrium while decreasing intrauterine adhesion scores...
May 2016: Human Reproduction
https://www.readbyqxmd.com/read/26982384/effectiveness-of-estrogen-treatment-before-transcervical-resection-of-adhesions-on-moderate-and-severe-uterine-adhesion-patients
#13
Ai-Zhen Liu, Hong-Guo Zhao, Ying Gao, Ming Liu, Bao-Zhi Guo
Intrauterine adhesion (IUA), also known as Asherman's syndrome, is a common disease for among women. The extent of adhesion and pre-surgery hormone therapy greatly affects the function of uterine cavity. This current study investigates the association of different doses of estrogen before transcervical resection of adhesions (TCRA) surgery and clinical outcome in serious IUA. About 120 newly diagnostic serious IUA patients who underwent TCRA were randomly divided into three study groups: Estradiol valerate (progynova) 3 or 9 mg per diet before surgery and the control group...
March 16, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/26962478/induction-of-asherman-s-syndrome-in-rabbit
#14
Sanaz Bazoobandi, Nader Tanideh, Farhad Rahmanifar, Amin Tamadon, Mohammadreza Keshtkar, Davood Mehrabani, Maryam Kasraeian, Omid Koohi-Hosseinabadi
BACKGROUND: Uterine synechiae or Asherman's syndrome is a condition that can cause infertility. The present experimental study was designed to establish the rabbit as an animal model for human Asherman's syndrome using the endometrial curettage. METHODS: In an experimental study, female adult rabbits (n=18) were randomly divided into intact and ovariectomized groups. One third of caudal part of both uteri was submitted to traumatic endometrial curettage. One group was simultaneously ovariectomized...
January 2016: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/26865543/aberrant-hoxa10-methylation-in-patients-with-common-gynecologic-disorders-implications-for-reproductive-outcomes
#15
Jennifer L Kulp, Ramanaiah Mamillapalli, Hugh S Taylor
HomeoboxA10 (HOXA10) is a transcription factor that is crucial for the development and patterning of the uterus during embryogenesis. In the adult endometrium, HOXA10 expression is regulated by steroid hormones and embryonic signals. Expression of sufficient HOXA10 messenger RNA is essential to endometrial receptivity and embryo implantation. Aberrant methylation is believed to alter the expression of HOXA10. Methylation of this gene may be associated with decreased fertility, implantation defects, and/or reproductive wastage seen in certain disease states that affect the female reproductive tract...
April 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/26552890/endometrial-stem-progenitor-cells-the-first-10-years
#16
REVIEW
Caroline E Gargett, Kjiana E Schwab, James A Deane
BACKGROUND: The existence of stem/progenitor cells in the endometrium was postulated many years ago, but the first functional evidence was only published in 2004. The identification of rare epithelial and stromal populations of clonogenic cells in human endometrium has opened an active area of research on endometrial stem/progenitor cells in the subsequent 10 years. METHODS: The published literature was searched using the PubMed database with the search terms 'endometrial stem cells and menstrual blood stem cells' until December 2014...
March 2016: Human Reproduction Update
https://www.readbyqxmd.com/read/26534897/dilatation-and-curettage-increases-the-risk-of-subsequent-preterm-birth-a-systematic-review-and-meta-analysis
#17
REVIEW
M Lemmers, M A C Verschoor, A B Hooker, B C Opmeer, J Limpens, J A F Huirne, W M Ankum, B W M Mol
STUDY QUESTION: Could dilatation and curettage (D&C), used in the treatment of miscarriage and termination of pregnancy, increase the risk of subsequent preterm birth? SUMMARY ANSWER: A history of curettage in women is associated with an increased risk of preterm birth in a subsequent pregnancy compared with women without such history. WHAT IS KNOWN ALREADY: D&C is one of the most frequently performed procedures in obstetrics and gynaecology...
January 2016: Human Reproduction
https://www.readbyqxmd.com/read/26484781/asherman-syndrome-an-unsolved-clinical-definition-and-management
#18
EDITORIAL
Errico Zupi, Gabriele Centini, Lucia Lazzeri
No abstract text is available yet for this article.
December 2015: Fertility and Sterility
https://www.readbyqxmd.com/read/26428306/results-of-centralized-asherman-surgery-2003-2013
#19
Miriam M F Hanstede, Eva van der Meij, Laurien Goedemans, Mark Hans Emanuel
OBJECTIVE: To study the success rate of hysteroscopic adhesiolysis and the spontaneous recurrence rate of intrauterine adhesions (IUAs) in patients with Asherman syndrome. DESIGN: Cohort study. SETTING: University-affiliated hospitals. PATIENT(S): A total of 638 women with Asherman syndrome were included, all diagnosed using hysteroscopy, and operated on between 2003 and 2013. INTERVENTION(S): Hysteroscopic adhesiolysis...
December 2015: Fertility and Sterility
https://www.readbyqxmd.com/read/26384164/human-cd133-bone-marrow-derived-stem-cells-promote-endometrial-proliferation-in-a-murine-model-of-asherman-syndrome
#20
Irene Cervelló, Claudia Gil-Sanchis, Xavier Santamaría, Sergio Cabanillas, Ana Díaz, Amparo Faus, Antonio Pellicer, Carlos Simón
OBJECTIVE: To investigate the engraftment and proliferation of superparamagnetic iron oxide nanoparticles (SPIOs)-labeled human CD133(+) bone marrow-derived stem cells (BMDSCs) in an animal model of Asherman syndrome (AS). DESIGN: Prospective experimental animal study. SETTING: University research laboratories. ANIMAL(S): Nonobese diabetic mice (strain code 394; NOD.CB17- Prkdc(scid)/NcrCrl) in which AS was induced according to a published protocol...
December 2015: Fertility and Sterility
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