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Asiaticoside AND smad

Xin Wu, Difei Bian, Yannong Dou, Zhunan Gong, Qian Tan, Yufeng Xia, Yue Dai
Higher expression of growth differentiation factor-9 (GDF-9) in keloids compared with hypertrophic scars and normal skin tissues has been reported recently. The present study was performed to investigate the role of GDF-9 in keloid pathogenesis, and to elucidate its implication for asiaticoside in the keloid management. The data showed that GDF-9 could enhance the proliferation, migration, and invasion of keloid fibroblasts (KFs), while it only slightly elevated collagen expression, indicating that the effect of GDF-9 was opposite to that of TGF-β1...
August 2017: Journal of Biochemical and Molecular Toxicology
Xiao-Bing Wang, Wu Wang, Xiao-Chun Zhu, Wen-Jing Ye, Hui Cai, Pei-Liang Wu, Xiao-Ying Huang, Liang-Xing Wang
AIMS: Asiaticoside (AS) is a saponin monomer extracted from the medicinal plant Centella asiatica, which has a variety of biological effects. We intended to investigate the effects of asiaticoside on a hypoxia-induced pulmonary hypertension (HPH) rat model and examine the possible effects of asiaticoside on TGF-β1/Smad signaling in vivo and in vitro. MAIN METHODS: The rat HPH model was established by hypoxic exposure and asiaticoside was administered for four weeks...
September 15, 2015: Life Sciences
Fang Wu, Difei Bian, Yufeng Xia, Zhunan Gong, Qian Tan, Jiaojiao Chen, Yue Dai
Centella asiatica herbs have been prescribed as a traditional medicine for wound healing in China and Southeast Asia for a long time. They contain many kinds of triterpenoid compounds, mainly including glycosides (asiaticoside and madecassoside) and corresponding aglycones (asiatic acid and madecassic acid). To identify which is the major active constituent, a comprehensive and comparative study of these compounds was performed. In vitro, primary human skin fibroblasts, originating from healthy human foreskin samples, were treated with various concentrations of asiaticoside, madecassoside, asiatic acid, and madecassic acid, respectively...
2012: Evidence-based Complementary and Alternative Medicine: ECAM
Bing Tang, Bin Zhu, Yueying Liang, Liangkuan Bi, Zhicheng Hu, Bin Chen, Kai Zhang, Jiayuan Zhu
Asiaticoside (ATS) isolated from the leaves of Centella asiatica possesses strong wound-healing properties and reduces scar formation. However, the specific effects of asiaticoside on the formation of keloidal scars remain unknown. In the present study, we evaluated the in vitro effects of asiaticoside on the proliferation, collagen expression, and transforming growth factor (TGF)-β/Smad signaling of keloid-derived fibroblasts. Fibroblasts isolated from keloid tissue and normal skin tissues were treated with asiaticoside at different concentrations...
October 2011: Archives of Dermatological Research
Xie Ju-Lin, Qi Shao-Hai, Li Tian-Zeng, Huang Bin, Tang Jing-Ming, Xu Ying-Bin, Liu Xu-Sheng, Shu Bin, Liang Hui-Zhen, Huang Yong
BACKGROUND: Previous observations suggested that asiaticoside had a possible antiscaring effect. However, the precise pathological mechanism still remain unknown. We questioned whether asiaticoside might alleviate the formation of hypertrophic scar by affecting the expression of Transform growth factor beta (TGF-beta)/Smad signaling. AIMS: To investigate the effect of asiaticoside on the expression of TGF-beta/Smad signaling in the rabbit ear model of hypertrophic scar and to clarify the mechanism of asiaticoside on the scar treatment...
February 2009: Journal of Cutaneous Pathology
S H Qi, J-L Xie, S Pan, Y-B Xu, T-Z Li, J-M Tang, X-S Liu, B Shu, P Liu
BACKGROUND: The precise mechanism of asiaticoside in molecular and gene expression levels of Smad protein and mRNA still remains unknown. We hypothesised that asiaticoside might inhibit the formation of hypertrophic scarring by affecting the expression of Smad protein and interfering with the Smad signalling pathway. AIMS: To investigate the effects of asiaticoside on the expression of Smad protein by hypertrophic scar fibroblasts (HSFs) and to clarify the mechanism of asiaticoside in scar treatment...
March 2008: Clinical and Experimental Dermatology
Jongsung Lee, Eunsun Jung, Youngji Kim, Junho Park, Jinil Park, Sungtaek Hong, Jieun Kim, Changgu Hyun, Yeong Shik Kim, Deokhoon Park
Skin aging appears to be principally related to a decrease in the levels of type I collagen, the primary component of the skin dermis. Asiaticoside, a saponin component isolated from Centella asiatica, has been shown to induce type I collagen synthesis in human dermal fibroblast cells. However, the mechanism underlying asiaticoside-induced type I collagen synthesis, especially at a molecular level, remains only partially understood. In this study, we have attempted to characterize the action mechanism of asiaticoside in type I collagen synthesis...
March 2006: Planta Medica
Shu Pan, Tianzeng Li, Yeyang Li
OBJECTIVE: To investigate the effects of asiaticoside on the proliferation and the Smad signal pathway of the hypertrophic scar fibroblasts. METHODS: The hypertrophic scar fibroblasts were cultured with tissue culture method. The expressions of Smad2 and Smad7 mRNA after asiaticoside treatment were determined by reverse transcription-polymerase chain reaction 48 hours later. The cell cycle, the cell proliferation, the cell apoptosis and the expression of phosphorylated Smad2 and Smad7 with (experimental group) or without (control group) asiaticoside were detected with flow cytometry, immunocytochemistry and Western blot...
July 2004: Chinese Journal of Reparative and Reconstructive Surgery
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