Wan-Yi Zhao, Li-Yun Zhang, Zheng-Cai Wang, Qing-Qing Fang, Xiao-Feng Wang, Yong-Zhong Du, Bang-Hui Shi, Dong Lou, Gui-Da Xuan, Wei-Qiang Tan
The role of angiotensin receptor blocker in wound healing and cutaneous fibrosis has become a hotspot in recent years. We have developed a losartan cream that is comparable to triamcinolone ointment in inhibiting scarring. Considering the effects of chitosan and asiaticoside on wound healing and scarring, we added them to the losartan cream this time and improved the formula, expecting to get a better anti-scarring effect. The effects of creams were investigated on mouse scar model with triamcinolone ointment, onion extract gel, and commercial asiaticoside cream set as positive controls...
August 22, 2022: Scientific Reports