Seth J Rotz, Betty K Hamilton, Wei Wei, Ibrahim Ahmed, Sameeya Ahmed Winston, Sherri Ballard, Robyn J Bernard, Paul Carpenter, Nosha Farhadfar, Christina Ferraro, Brian D Friend, Nicholas J Gloude, Robert J Hayashi, Kerry Hoyle, Kari Jenssen, Jane Koo, Catherine J Lee, Livia Mariano, Rawan Nawabit, Alexander Ngwube, Nahal Lalefar, Rachel Phelan, Laynie Perkins, Anandini Rao, Ahmad Rayes, Taryn Sandheinrich, Lauren Stafford, Kathryn Tomlinson, Stacy Whiteside, Christina Wiedl, Kasiani Myers
BACKGROUND: Use of reduced intensity conditioning (RIC) regimens has increased to minimize hematopoietic cell transplantation (HCT) end-organ toxicity, including gonadal toxicity. OBJECTIVE: We aimed to describe the incidence of fertility potential and gonadal function impairment in adolescent and young adult survivors of HCT and determine risk factors (including conditioning intensity) for impairment. STUDY DESIGN: We performed a multi-institutional, international, retrospective cohort study of patients ages 10-40 who underwent first allogeneic HCT prior to December 1, 2019, and who are alive, in remission, and available for follow-up at one to two years post-HCT...
February 9, 2024: Transplantation and cellular therapy